pore domains
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scholarly journals Calmodulin Functionally Couples the KCNQ1 Channel Voltage-Sensing and Pore Domains

2020 ◽  
Vol 118 (3) ◽  
pp. 332a-333a
Author(s):  
Po Wei Kang ◽  
Annie M. Westerlund ◽  
Jingyi Shi ◽  
Kelli McFarland White ◽  
Alex K. Dou ◽  
...  
Keyword(s):  
Voltage Sensing ◽  
Pore Domains

Association of genetic polymorphisms in the pore domains of mechano-gated TREK-1 channel with overactive lower urinary tract symptoms in humans

2018 ◽  
Vol 38 (1) ◽  
pp. 144-150 ◽  
Author(s):  
Balachandar Nedumaran ◽  
Ricardo H. Pineda ◽  
Pratyaydipta Rudra ◽  
Sanghee Lee ◽  
Anna P. Malykhina
Keyword(s):  
Urinary Tract ◽  
Genetic Polymorphisms ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Urinary Tract Symptoms ◽  
Lower Urinary ◽  
Pore Domains

scholarly journals Swapping of transmembrane domains in the epithelial calcium channel TRPV6

2017 ◽  
Author(s):  
Appu K. Singh ◽  
Kei Saotome ◽  
Alexander I. Sobolevsky
Keyword(s):  
Ion Channels ◽  
Ion Channel ◽  
Calcium Channel ◽  
Transmembrane Domain ◽  
Transmembrane Domains ◽  
Domain Swapping ◽  
Structural Determinants ◽  
Disease States ◽  
Pore Domains

AbstractTetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.

scholarly journals Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Nicole Bobak ◽  
Sylvain Feliciangeli ◽  
Cheng-Chang Chen ◽  
Ismail Ben Soussia ◽  
Stefan Bittner ◽  
...  
Keyword(s):  
K Channel ◽  
Weakly Inward ◽  
Pore Domains

scholarly journals Dissecting the Folding Pathway of Potassium Channel Pore Domains

2016 ◽  
Vol 110 (3) ◽  
pp. 394a
Author(s):  
Kevin Song ◽  
Benoît Roux ◽  
Tobin Sosnick
Keyword(s):  
Potassium Channel ◽  
Folding Pathway ◽  
Channel Pore ◽  
Pore Domains

Chemistry in Confined Pore Domains

2015 ◽  
pp. 435-456
Author(s):  
Megan M. Otting ◽  
Yazhou Ji ◽  
Ryan M. Richards ◽  
Brian G. Trewyn
Keyword(s):  
Pore Domains

scholarly journals Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Éva Lörinczi ◽  
Juan Camilo Gómez-Posada ◽  
Pilar de la Peña ◽  
Adam P. Tomczak ◽  
Jorge Fernández-Trillo ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Voltage Sensing ◽  
Voltage Dependent ◽  
Pore Domains
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