The Pore of Voltage-Dependent Potassium Channels

1994 ◽  
Vol 17 (3-4) ◽  
pp. 178-181
Author(s):  
A.M. Brown
Keyword(s):  
Potassium Channels ◽  
Voltage Dependent

scholarly journals Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.

1991 ◽  
Vol 266 (12) ◽  
pp. 7583-7587
Author(s):  
M P Kavanaugh ◽  
M D Varnum ◽  
P B Osborne ◽  
M J Christie ◽  
A E Busch ◽  
...  
Keyword(s):  
Amino Acid ◽  
Potassium Channels ◽  
Amino Acid Residues ◽  
Voltage Dependent

scholarly journals Activation-inactivation of potassium channels and development of the potassium-channel spike in internally perfused squid giant axons.

1981 ◽  
Vol 78 (1) ◽  
pp. 43-61 ◽  
Author(s):  
I Inoue
Keyword(s):  
Potassium Channels ◽  
Potassium Channel ◽  
Voltage Clamp ◽  
Time Constant ◽  
Equilibrium Potential ◽  
Giant Axons ◽  
Dependent Inactivation ◽  
Voltage Dependent ◽  
Time Courses ◽  
Calcium Permeability

A spike that is the result of calcium permeability through potassium channels was separated from the action potential is squid giant axons internally perfused with a 30 mM NaF solution and bathed in a 100 mM CaCl2 solution by blocking sodium channels with tetrodotoxin. Currents through potassium channels were studied under voltage clamp. The records showed a clear voltage-dependent inactivation of the currents. The inactivation was composed of at least two components; one relatively fast, having a time constant of 20--30 ms, and the other very slow, having a time constant of 5--10 s. Voltage clamp was carried out with a variety of salt compositions in both the internal and external solutions. A similar voltage-dependent inactivation, also composed of the two components, was recognized in all the current through potassium channels. Although the direction and intensity of current strongly depended on the salt composition of the solutions, the time-courses of these currents at corresponding voltages were very similar. These results strongly suggest that the inactivation of the currents in attributable to an essential, dynamic property of potassium channels themselves. Thus, the generation of a potassium-channel spike can be understood as an event that occurs when the equilibrium potential across the potassium channel becomes positive.

scholarly journals Role of L‐type voltage dependent calcium and large conductance potassium channels in adenosine A 1 receptor mediated vasoconstriction through Cyp4a

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Swati S Kunduri ◽  
Mohammed A Nayeem ◽  
Dovenia S Ponnoth ◽  
Stephen Tilley ◽  
S. Jamal Mustafa
Keyword(s):  
Potassium Channels ◽  
Voltage Dependent

Blockade of two voltage-dependent potassium channels, mKv1.1 and mKv1.2, by docosahexaenoic acid

1996 ◽  
Vol 314 (3) ◽  
pp. 393-396 ◽  
Author(s):  
Jennifer C. Garratt ◽  
Matthew P. McEvoy ◽  
David G. Owen
Keyword(s):  
Potassium Channels ◽  
Docosahexaenoic Acid ◽  
Voltage Dependent

scholarly journals Molecular Determinants of Voltage-Dependent Gating in hERG Potassium Channels

2012 ◽  
Vol 102 (3) ◽  
pp. 329a
Author(s):  
Yen May Cheng ◽  
Christina M. Hull ◽  
Christine M. Niven ◽  
Charlene R. Allard ◽  
Tom W. Claydon
Keyword(s):  
Potassium Channels ◽  
Molecular Determinants ◽  
Voltage Dependent

Subdiaphragmatic vagotomy increases the sensitivity of lumbar Aδ primary afferent neurons along with voltage-dependent potassium channels in rats

Synapse ◽  
2011 ◽  
Vol 66 (2) ◽  
pp. 95-105 ◽  
Author(s):  
Sadayoshi Furuta ◽  
Lisa Watanabe ◽  
Seira Doi ◽  
Hiroshi Horiuchi ◽  
Kenjiro Matsumoto ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Afferent Neurons ◽  
Primary Afferent Neurons ◽  
Primary Afferent ◽  
Subdiaphragmatic Vagotomy ◽  
Voltage Dependent

Potassium channels activated by GABAB agonists and serotonin in cultured hippocampal neurons

1994 ◽  
Vol 71 (6) ◽  
pp. 2570-2575 ◽  
Author(s):  
L. S. Premkumar ◽  
P. W. Gage
Keyword(s):  
Potassium Channels ◽  
Hippocampal Neurons ◽  
Single Channel ◽  
Gamma Aminobutyric Acid ◽  
Kinetic Behavior ◽  
Open Time ◽  
Voltage Dependent ◽  
Single Channel Currents ◽  
Channel Currents ◽  
Cultured Hippocampal Neurons

1. Single-channel currents were recorded in cell-attached patches on cultured hippocampal neurons in response to gamma-aminobutyric acid-B (GABAB) agonists or serotonin applied to the cell surface outside the patch area. 2. The channels activated by GABAB agonists and serotonin were potassium selective but had a different conductance and kinetic behavior. Channels activated by GABAB agonists had a higher conductance, longer open-time, and longer burst-length than channels activated by serotonin. 3. The kinetic behavior of channels activated by GABAB agonists varied with potential whereas channels activated by serotonin did not show voltage-dependent changes in kinetics. 4. In a few cell-attached patches, both types of channel were activated when the cell was exposed to GABA together with serotonin. 5. It was concluded that GABAB agonists and serotonin activate different potassium channels in the soma of cultured hippocampal neurons.

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