scholarly journals Treatment Outcome-Related White Matter Differences in Veterans with Posttraumatic Stress Disorder

2015 ◽  
Vol 40 (10) ◽  
pp. 2434-2442 ◽  
Author(s):  
Mitzy Kennis ◽  
Sanne J H van Rooij ◽  
Do P M Tromp ◽  
Andrew S Fox ◽  
Arthur R Rademaker ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Treatment Outcome ◽  
White Matter ◽  
Posttraumatic Stress ◽  
Stress Disorder

Decreased Gray-To-White Matter Contrast Within the Ventromedial Prefrontal Cortex of Individuals With Posttraumatic Stress Disorder

2021 ◽  
Vol 89 (9) ◽  
pp. S231-S232
Author(s):  
Nathaniel Harnett ◽  
Sanne van Rooij ◽  
Timothy Ely ◽  
Jennifer Stevens ◽  
Antonia Seligowski ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Prefrontal Cortex ◽  
White Matter ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Ventromedial Prefrontal Cortex

Intrusive Thoughts in Posttraumatic Stress Disorder

2002 ◽  
Vol 16 (2) ◽  
pp. 127-143 ◽  
Author(s):  
Sherry A. Falsetti ◽  
Jeannine Monnier ◽  
Joanne L. Davis ◽  
Heidi S. Resnick
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Treatment Outcome ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Intrusive Thoughts ◽  
Panic Attacks ◽  
Trauma Survivors ◽  
Multiple Channel ◽  
Assessment And Treatment ◽  
Behavioral Treatments

This article reviews the literature on prevalence, associated features, assessment, and treatment of intrusive symptoms associated with posttraumatic stress disorder (PTSD). Research indicates that among trauma survivors, intrusive thoughts and imagery are quite common and distressing. It appears that early intrusions may be predictive of long-term distress and that avoidance and suppression can maintain intrusions. The treatment outcome literature for PTSD indicates that current cognitive behavioral treatments are effective in reducing intrusions. New data from a recent treatment outcome study for PTSD with comorbid panic attacks, using Multiple Channel Exposure Therapy, also suggest that this treatment is effective in significantly reducing intrusions.

scholarly journals Structural Connectivity of the Posterior Cingulum Is Related to Reexperiencing Symptoms in Posttraumatic Stress Disorder

2018 ◽  
Vol 2 ◽  
pp. 247054701880713 ◽  
Author(s):  
Carissa N. Weis ◽  
Emily L. Belleau ◽  
Walker S. Pedersen ◽  
Tara A. Miskovich ◽  
Christine L. Larson
Keyword(s):  
Posttraumatic Stress Disorder ◽  
White Matter ◽  
Posttraumatic Stress ◽  
Visual Memory ◽  
Stress Disorder ◽  
Structural Connectivity ◽  
Uncinate Fasciculus ◽  
Stress Exposure ◽  
Cingulum Bundle ◽  
Posttraumatic Stress Disorder Symptoms

Posttraumatic stress disorder is a heterogeneous disorder with disturbances in hyperarousal or avoidance behaviors and intrusive or reexperiencing thoughts. The uncinate fasciculus and cingulum bundle are white matter pathways implicated in stress and trauma pathophysiology, yet their structural integrity related to posttraumatic stress disorder symptom domains is yet to be understood. Forty-four trauma-exposed young adults underwent structural and diffusion-weighted magnetic resonance imaging. Stress and trauma exposure indices and severity of posttraumatic stress disorder symptoms were collected and used to predict current integrity of the uncinate fasciculus and cingulum bundle. Severity of reexperiencing posttraumatic stress disorder symptoms was significantly related to increased fractional anisotropy ( r = .469 p < .001) and decreased mean diffusivity ( r =  −.373, p = .013) of the right posterior cingulum bundle. No other findings emerged with respect to stress exposure or of hyperarousal ( p’s > 0.05) or avoidance ( p’s > 0.2) posttraumatic stress disorder symptoms. The posterior cingulum connects medial temporal lobe structures with visual areas in the occipital lobe and has been implicated in visual memory and self-referential thought. Increased structural connectivity along this pathway may therefore explain the emergence of reexperiencing posttraumatic stress disorder symptoms. This along with the lack of results with respect to stress exposure suggests that structural aberrations in white matter pathways are more strongly linked with the actual experience of stress-related psychological symptoms than just exposure to stress.

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