scholarly journals Psychotomimetic effects at initiation of cannabis use are associated with cannabinoid receptor 1 (CNR1) variants in healthy students

2014 ◽  
Vol 19 (4) ◽  
pp. 402-403 ◽  
Author(s):  
M O Krebs ◽  
Y Morvan ◽  
T Jay ◽  
R Gaillard ◽  
O Kebir
Keyword(s):  
Cannabinoid Receptor ◽  
Cannabis Use ◽  
Cannabinoid Receptor 1 ◽  
Psychotomimetic Effects

scholarly journals Cannabinoid Receptor 1 Gene by Cannabis Use Interaction on CB1 Receptor Density

2017 ◽  
Vol 2 (1) ◽  
pp. 202-209 ◽  
Author(s):  
Ariel Ketcherside ◽  
Lindsey J. Noble ◽  
Christa K. McIntyre ◽  
Francesca M. Filbey
Keyword(s):  
Cannabinoid Receptor ◽  
Cb1 Receptor ◽  
Cannabis Use ◽  
Receptor Density ◽  
Cannabinoid Receptor 1

scholarly journals Functional Genetic Variation of the Cannabinoid Receptor 1 and Cannabis Use Interact on Prefrontal Connectivity and Related Working Memory Behavior

2014 ◽  
Vol 40 (3) ◽  
pp. 640-649 ◽  
Author(s):  
Marco Colizzi ◽  
Leonardo Fazio ◽  
Laura Ferranti ◽  
Annamaria Porcelli ◽  
Rita Masellis ◽  
...  
Keyword(s):  
Working Memory ◽  
Genetic Variation ◽  
Cannabinoid Receptor ◽  
Cannabis Use ◽  
Cannabinoid Receptor 1 ◽  
Functional Genetic Variation

Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis

2020 ◽  
Vol 29 (7) ◽  
pp. 616-622 ◽  
Author(s):  
Attila Oláh ◽  
Majid Alam ◽  
Jérémy Chéret ◽  
Nikolett Gréta Kis ◽  
Zoltán Hegyi ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cannabinoid Receptor ◽  
Human Epidermis ◽  
Cannabinoid Receptor 1 ◽  
Mitochondrial Energy Metabolism

scholarly journals Does variation in trait schizotypy and frequency of cannabis use influence the acute subjective, cognitive and psychotomimetic effects of delta-9-tetrahydrocannabinol? A mega-analysis

2021 ◽  
pp. 026988112095960
Author(s):  
Abigail M Freeman ◽  
Claire Mokrysz ◽  
Chandni Hindocha ◽  
Will Lawn ◽  
Celia JA Morgan ◽  
...  
Keyword(s):  
Personality Traits ◽  
Memory Impairment ◽  
Linear Models ◽  
Cannabis Use ◽  
Acute Effects ◽  
Double Blind ◽  
Schizotypal Personality ◽  
Domain Specific ◽  
Individual Participant ◽  
Psychotomimetic Effects

Background: While the acute effects of cannabis are relatively benign for most users, some individuals experience significant adverse effects. This study aimed to identify whether variation in schizotypal personality traits and frequency of cannabis use influence the acute effects of delta-9-tetrahydrocannabinol (THC). Methods: Individual participant data from four double-blind, randomised, placebo-controlled, acute crossover studies involving 128 cannabis users were combined for a mega-analysis. Using multilevel linear models and moderation analyses, frequency of cannabis use and schizotypal personality traits were investigated as potential moderators of the subjective, cognitive and psychotomimetic effects of acute THC. Results: There was evidence of a moderating effect where increased frequency of cannabis use was associated with reduced intensity of subjective (changes in alertness and feeling stoned) and psychosis-like effects following THC when compared with placebo. Moderating effects of cannabis use frequency on acute memory impairment were weak. Trait schizotypy did not moderate the acute psychosis-like effects of THC compared with placebo. Conclusions: Our results suggest that a pattern of domain-specific tolerance develops to the acute effects of THC. Tolerance to the alertness-reducing effects occurred more readily than tolerance to psychotomimetic effects. Only partial tolerance to feeling stoned was found, and there was weak evidence for tolerance to memory impairment. Trait schizotypy did not moderate THC’s effects on psychotomimetic symptoms.

scholarly journals Audiograms, gap detection thresholds, and frequency difference limens in cannabinoid receptor 1 knockout mice

2016 ◽  
Vol 332 ◽  
pp. 217-222 ◽  
Author(s):  
Katrina L. Toal ◽  
Kelly E. Radziwon ◽  
David P. Holfoth ◽  
Matthew A. Xu-Friedman ◽  
Micheal L. Dent
Keyword(s):  
Knockout Mice ◽  
Cannabinoid Receptor ◽  
Frequency Difference ◽  
Gap Detection ◽  
Cannabinoid Receptor 1 ◽  
Detection Thresholds
Sign in / Sign up

Export Citation Format

Share Document