scholarly journals Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

2014 ◽  
Vol 13 (6) ◽  
pp. 599-604 ◽  
Author(s):  
Yubing Sun ◽  
Koh Meng Aw Yong ◽  
Luis G. Villa-Diaz ◽  
Xiaoli Zhang ◽  
Weiqiang Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Neuron Differentiation

scholarly journals Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells

2015 ◽  
Vol 8 (1) ◽  
Author(s):  
Daisuke Shimojo ◽  
Kazunari Onodera ◽  
Yukiko Doi-Torii ◽  
Yasuharu Ishihara ◽  
Chinatsu Hattori ◽  
...  
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Neuron Differentiation ◽  
Simple Motor

scholarly journals High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Qiuhao Qu ◽  
Dong Li ◽  
Kathleen R. Louis ◽  
Xiangzhen Li ◽  
Hong Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Pluripotent Stem Cells ◽  
High Efficiency ◽  
Human Pluripotent Stem Cells ◽  
Neuron Differentiation ◽  
Islet 1

scholarly journals Nanotopography regulates motor neuron differentiation of human pluripotent stem cells

Nanoscale ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 3556-3565 ◽  
Author(s):  
Weiqiang Chen ◽  
Shuo Han ◽  
Weiyi Qian ◽  
Shinuo Weng ◽  
Haiou Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Motor Neuron ◽  
Pluripotent Stem Cells ◽  
Stem Cell Niche ◽  
Human Pluripotent Stem Cells ◽  
Neuron Differentiation ◽  
Cell Niche

Nanotopographic cues in the stem cell niche regulate the motor neuron differentiation of human pluripotent stem cells.

Effective motor neuron differentiation of hiPSCs on a patch made of crosslinked monolayer gelatin nanofibers

2016 ◽  
Vol 4 (19) ◽  
pp. 3305-3312 ◽  
Author(s):  
Yadong Tang ◽  
Li Liu ◽  
Junjun Li ◽  
Leqian Yu ◽  
Francesco Paolo Ulloa Severino ◽  
...  
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Electrode Array ◽  
Plug And Play ◽  
Neuron Differentiation ◽  
Neuron Spike ◽  
Induced Pluripotent ◽  
Multi Electrode Array

A patch made of crosslinked monolayer nanofibers was used for motor neuron differentiation from human induced pluripotent stem cells and plug-and-play with a commercial multi-electrode array for neuron spike recording.

scholarly journals Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhong-Wei Du ◽  
Hong Chen ◽  
Huisheng Liu ◽  
Jianfeng Lu ◽  
Kun Qian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Pure Motor

scholarly journals Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells

2012 ◽  
Vol 90 (7) ◽  
pp. 1367-1381 ◽  
Author(s):  
Catherine M. Schwartz ◽  
Tahereh Tavakoli ◽  
Charmaine Jamias ◽  
Sung-Soo Park ◽  
Stuart Maudsley ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Dopaminergic Neuron ◽  
Human Pluripotent Stem Cells ◽  
Neuron Differentiation

scholarly journals Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Rickie Patani
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Motor Neurons ◽  
Pluripotent Stem Cells ◽  
Muscular Atrophy ◽  
Human Pluripotent Stem Cells ◽  
Disease Models ◽  
Differential Vulnerability ◽  
Neuronal Diversification

Resolving the mechanisms underlying human neuronal diversification remains a major challenge in developmental and applied neurobiology. Motor neurons (MNs) represent a diverse pool of neuronal subtypes exhibiting differential vulnerability in different human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). The ability to predictably manipulate MN subtype lineage restriction from human pluripotent stem cells (PSCs) will form the essential basis to establishing accurate, clinically relevantin vitrodisease models. I first overview motor neuron developmental biology to provide some context for reviewing recent studies interrogating pathways that influence the generation of MN diversity. I conclude that motor neurogenesis from PSCs provides a powerful reductionist model system to gain insight into the developmental logic of MN subtype diversification and serves more broadly as a leading exemplar of potential strategies to resolve the molecular basis of neuronal subclass differentiation within the nervous system. These studies will in turn permit greater mechanistic understanding of differential MN subtype vulnerability usingin vitrohuman disease models.

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