scholarly journals Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhong-Wei Du ◽  
Hong Chen ◽  
Huisheng Liu ◽  
Jianfeng Lu ◽  
Kun Qian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Pure Motor

scholarly journals Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells

2015 ◽  
Vol 8 (1) ◽  
Author(s):  
Daisuke Shimojo ◽  
Kazunari Onodera ◽  
Yukiko Doi-Torii ◽  
Yasuharu Ishihara ◽  
Chinatsu Hattori ◽  
...  
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Neuron Differentiation ◽  
Simple Motor

scholarly journals Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Rickie Patani
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Motor Neurons ◽  
Pluripotent Stem Cells ◽  
Muscular Atrophy ◽  
Human Pluripotent Stem Cells ◽  
Disease Models ◽  
Differential Vulnerability ◽  
Neuronal Diversification

Resolving the mechanisms underlying human neuronal diversification remains a major challenge in developmental and applied neurobiology. Motor neurons (MNs) represent a diverse pool of neuronal subtypes exhibiting differential vulnerability in different human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). The ability to predictably manipulate MN subtype lineage restriction from human pluripotent stem cells (PSCs) will form the essential basis to establishing accurate, clinically relevantin vitrodisease models. I first overview motor neuron developmental biology to provide some context for reviewing recent studies interrogating pathways that influence the generation of MN diversity. I conclude that motor neurogenesis from PSCs provides a powerful reductionist model system to gain insight into the developmental logic of MN subtype diversification and serves more broadly as a leading exemplar of potential strategies to resolve the molecular basis of neuronal subclass differentiation within the nervous system. These studies will in turn permit greater mechanistic understanding of differential MN subtype vulnerability usingin vitrohuman disease models.

scholarly journals High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Qiuhao Qu ◽  
Dong Li ◽  
Kathleen R. Louis ◽  
Xiangzhen Li ◽  
Hong Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Pluripotent Stem Cells ◽  
High Efficiency ◽  
Human Pluripotent Stem Cells ◽  
Neuron Differentiation ◽  
Islet 1

scholarly journals Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

2014 ◽  
Vol 13 (6) ◽  
pp. 599-604 ◽  
Author(s):  
Yubing Sun ◽  
Koh Meng Aw Yong ◽  
Luis G. Villa-Diaz ◽  
Xiaoli Zhang ◽  
Weiqiang Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Motor Neuron ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Neuron Differentiation

scholarly journals Nanotopography regulates motor neuron differentiation of human pluripotent stem cells

Nanoscale ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 3556-3565 ◽  
Author(s):  
Weiqiang Chen ◽  
Shuo Han ◽  
Weiyi Qian ◽  
Shinuo Weng ◽  
Haiou Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Motor Neuron ◽  
Pluripotent Stem Cells ◽  
Stem Cell Niche ◽  
Human Pluripotent Stem Cells ◽  
Neuron Differentiation ◽  
Cell Niche

Nanotopographic cues in the stem cell niche regulate the motor neuron differentiation of human pluripotent stem cells.

Differentiation of human pluripotent stem cells into airway epithelial cells

Pneumologie ◽  
2015 ◽  
Vol 69 (07) ◽  
Author(s):  
S Ulrich ◽  
S Weinreich ◽  
R Haller ◽  
S Menke ◽  
R Olmer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Epithelial Cells ◽  
Pluripotent Stem Cells ◽  
Airway Epithelial Cells ◽  
Human Pluripotent Stem Cells ◽  
Airway Epithelial

326-LB: BCL-xL/BCL2L1 Is a Critical Anti-Apoptotic Protein that Suppresses BAK to Promote Pancreatic Specification from Human Pluripotent Stem Cells

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 326-LB
Author(s):  
LARRY SAI WENG LOO ◽  
ADRIAN TEO ◽  
SOUMITA GHOSH ◽  
ANDREAS ALVIN PURNOMO SOETEDJO ◽  
LINH NGUYEN ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Apoptotic Protein
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