scholarly journals Molecular evolution of the human interleukin–8 receptor gene cluster

1992 ◽  
Vol 2 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Sunil K. Ahuja ◽  
Tayfun Özçelik ◽  
Athena Milatovitch ◽  
Uta Francke ◽  
Philip M. Murphy
BMC Genomics ◽  
2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Alessandra F Ribas ◽  
Alberto Cenci ◽  
Marie-Christine Combes ◽  
Hervé Etienne ◽  
Philippe Lashermes

2002 ◽  
Vol 11 (2) ◽  
pp. 65-72 ◽  
Author(s):  
Imran M. Khan ◽  
Erin Singletary ◽  
Adamu Alemayehu ◽  
Shanaka Stanislaus ◽  
Morton P. Printz ◽  
...  

Spontaneously hypertensive rats (SHR) exhibit enhanced pressor, heart rate, and nociceptive responses to spinal nicotinic agonists. This accompanies a paradoxical decrease in spinal nicotinic receptor number in SHR compared with normotensive rats. The congenic strain, SHR-Lx, with an introgressed chromosome 8 segment from the normotensive Brown-Norway-Lx strain (BN-Lx) exhibits reduced blood pressure. This segment contains a gene cluster for three nicotinic receptor subunits expressed in the nervous system. We examined the implication of this gene cluster in the enhanced responsiveness of the SHR. Pressor and nociceptive responses to spinal cytisine, a nicotinic agonist, were diminished in SHR-Lx. Moreover, with repeated administration, these responses desensitized faster in SHR-Lx and progenitor BN-Lx than in progenitor SHR/Ola. This implicates the gene cluster in both cardiovascular and nociceptive responses to spinal nicotinic agonists. Since diminished responsiveness to agonist stimulation is greater than the basal blood pressure differences between the strains and the introgressed rat chromosome maps to a quantitative trait locus in human hypertension, polymorphisms in the three nicotinic receptor genes become candidates for altered central control of blood pressure.


2007 ◽  
Vol 26 (14) ◽  
pp. 3423-3430 ◽  
Author(s):  
Daniele Roppolo ◽  
Sarah Vollery ◽  
Chen-Da Kan ◽  
Christian Lüscher ◽  
Marie-Christine Broillet ◽  
...  

2005 ◽  
Vol 22 (6) ◽  
pp. 1433-1443 ◽  
Author(s):  
Yusuke Taguchi ◽  
Tsuyoshi Koide ◽  
Toshihiko Shiroishi ◽  
Takeshi Yagi

2004 ◽  
Vol 74 (4) ◽  
pp. 637-646 ◽  
Author(s):  
Stephen Wooding ◽  
Un-kyung Kim ◽  
Michael J. Bamshad ◽  
Jennifer Larsen ◽  
Lynn B. Jorde ◽  
...  

Genomics ◽  
1998 ◽  
Vol 51 (2) ◽  
pp. 270-276 ◽  
Author(s):  
Ji-Liang Gao ◽  
Hubert Chen ◽  
Jane D. Filie ◽  
Christine A. Kozak ◽  
Philip M. Murphy

2019 ◽  
Vol 10 ◽  
Author(s):  
Julien Lejeune ◽  
Guillaume Brachet ◽  
Hervé Watier

2006 ◽  
Vol 7 (1) ◽  
pp. 277-300 ◽  
Author(s):  
Arman A. Bashirova ◽  
Maureen P. Martin ◽  
Daniel W. McVicar ◽  
Mary Carrington
Keyword(s):  

Nephrology ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 464-471 ◽  
Author(s):  
Shi‐Sheng Han ◽  
Yan Lu ◽  
Min Chen ◽  
Yan‐Qiu Xu ◽  
Yi Wang

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