Association between interleukin 8‐receptor gene (CXCR1 and CXCR2) polymorphisms and urinary tract infection: Evidence from 4097 subjects

Nephrology ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 464-471 ◽  
Author(s):  
Shi‐Sheng Han ◽  
Yan Lu ◽  
Min Chen ◽  
Yan‐Qiu Xu ◽  
Yi Wang
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Receptor Gene ◽  
Interleukin 8

Urine Interleukin-8 Is a Marker for Urinary Tract Infection in Postoperative Patients

Infection ◽  
2001 ◽  
Vol 29 (5) ◽  
pp. 274-277 ◽  
Author(s):  
D.P. Olszyna ◽  
H. Vermeulen ◽  
A.H. Baan ◽  
P. Speelman ◽  
S.J.H. van Deventer ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Interleukin 8

Urinary interleukin-6 and interleukin-8 in children with urinary tract infection

2000 ◽  
Vol 15 (3-4) ◽  
pp. 236-240 ◽  
Author(s):  
B. A. Jantausch ◽  
Regina O'Donnell ◽  
Bernhard L. Wiedermann
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Interleukin 6 ◽  
Interleukin 8

Vitamin D receptor gene polymorphism in children with urinary tract infection

2011 ◽  
Vol 27 (3) ◽  
pp. 417-421 ◽  
Author(s):  
Sule Aslan ◽  
Ipek Akil ◽  
Gulcin Aslan ◽  
Huseyin Onay ◽  
Beyhan Cengiz Ozyurt ◽  
...  
Keyword(s):  
Vitamin D ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Gene Polymorphism ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphism

scholarly journals Redundancy and Specificity ofEscherichia coliIron Acquisition Systems during Urinary Tract Infection

2011 ◽  
Vol 79 (3) ◽  
pp. 1225-1235 ◽  
Author(s):  
Erin C. Garcia ◽  
Ariel R. Brumbaugh ◽  
Harry L. T. Mobley
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Iron Acquisition ◽  
Receptor Gene ◽  
Uncomplicated Urinary Tract Infection ◽  
Upec Strain ◽  
Relative Contribution ◽  
Receptor Mutant

ABSTRACTUropathogenicEscherichia coli(UPEC), the predominant cause of uncomplicated urinary tract infection (UTI), utilizes an array of outer membrane iron receptors to facilitate siderophore and heme import from within the iron-limited urinary tract. While these systems are required for UPECin vivofitness and are assumed to be functionally redundant, the relative contributions of specific receptors to pathogenesis are unknown. To delineate the relative roles of distinct UPEC iron acquisition systems in UTI, isogenic mutants in UPEC strain CFT073 or 536 lacking individual receptors were competed against one anotherin vivoin a series of mixed infections. When combinations of up to four mutants were coinoculated using a CBA/J mouse model of ascending UTI, catecholate receptor mutants (ΔfepA, Δiha, and ΔiroNmutants) were equally fit, suggesting redundant function. However, noncatecholate siderophore receptor mutants, including the ΔiutAaerobactin receptor mutant and the ΔfyuAyersiniabactin receptor mutant, were frequently outcompeted by coinoculated mutants, indicating that these systems contribute more significantly to UPEC iron acquisitionin vivo. A tissue-specific preference for heme acquisition was also observed, as a heme uptake-deficient ΔhmaΔchuAdouble mutant was outcompeted by siderophore receptor mutants specifically during kidney colonization. The relative contribution of each receptor to UTI only partially correlated within vivolevels of receptor gene expression, indicating that other factors likely contributed to the observed fitness differences. Overall, our results suggest that UPEC iron receptors provide both functional redundancy and niche specificity for this pathogen as it colonizes distinct sites within the urinary tract.

Study on vitamin D receptor gene polymorphisms in patients with urinary tract infections conducted in Northwestern Mexico

2018 ◽  
Vol 78 (6) ◽  
Author(s):  
Denisse Stephania Becerra-Loaiza ◽  
Jorge Guillermo Sánchez-Zazueta ◽  
Luis Antonio Ochoa-Ramírez ◽  
Ismael Velarde-Rodríguez ◽  
José Rodríguez-Millán ◽  
...  
Keyword(s):  
Vitamin D ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Vitamin D Receptor ◽  
Statistical Significance ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Cross Sectional ◽  
Tract Infections

OBJECTIVE: To evaluate the influence of the polymorphisms of the vitamin D receptor gene (FokI: rs2228570, BsmI: rs1544410, ApaI: rs7975232, and TaqI: rs731236) on the clinical parameters of patients with urinary tract infections.MATERIALS AND METHODS: A comparative, prospective, and cross-sectional study was conducted at the Hospital General de Culiacán Dr. Bernardo J. Gastélum within the time frame of August 2016 to July 2017. The polymorphisms were detected through the polymerase chain reaction-restriction fragment length method in 119 patients diagnosed with urinary tract infection and in 206 individuals with no urinary tract infection. The data analysis was carried out using the c2 and odds ratio (OR) with a 95% confidence interval (95%CI). The logistic regression method, adjusted by age and sex, was employed to evaluate the relation between clinical characteristics and genotypes, utilizing the STATA version 13.0 program. Statistical significance was set at a p<0.05.RESULTS: We found differences in the prevalence of the CA-ApaI genotype between the study groups. The FokI and BsmI polymorphisms and the TGAT and CGCT haplotypes were associated with certain clinical characteristics.CONCLUSIONS: A possible link between the vitamin D receptor gene and bacterial urinary tract infection in a Mexican population was suggested.KEYWORDS: Vitamin D receptor; Urinary tract infection; Polymorphisms; Haplotypes.

scholarly journals Vitamin D receptor gene (FokI, TaqI, BsmI, and ApaI) polymorphisms in children with urinary tract infection

2018 ◽  
Vol 84 (4) ◽  
pp. 527-532
Author(s):  
Abolfazl Mahyar ◽  
Parviz Ayazi ◽  
Arshnoos Sarkhosh Afshar ◽  
Taghi Naserpour Farivar ◽  
Mehdi Sahmani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene

scholarly journals Serum interleukin -8 is not a reliable marker for prediction of vesicoureteral reflux in children with febrile urinary tract infection

2015 ◽  
Vol 41 (6) ◽  
pp. 1160-1166 ◽  
Author(s):  
Abolfazl Mahyar ◽  
Parviz Ayazi ◽  
Mohammad Hadi Yarigarravesh ◽  
Mohammad Hossein Khoeiniha ◽  
Sonia Oveisi ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Vesicoureteral Reflux ◽  
Interleukin 8 ◽  
Febrile Urinary Tract Infection ◽  
Reliable Marker
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