Differential Expansion of the N-Formylpeptide Receptor Gene Cluster in Human and Mouse

Genomics ◽  
1998 ◽  
Vol 51 (2) ◽  
pp. 270-276 ◽  
Author(s):  
Ji-Liang Gao ◽  
Hubert Chen ◽  
Jane D. Filie ◽  
Christine A. Kozak ◽  
Philip M. Murphy
Keyword(s):  
Gene Cluster ◽  
Receptor Gene ◽  
Differential Expansion ◽  
Human And Mouse ◽  
Formylpeptide Receptor

Differential Expression of Members of the N-Formylpeptide Receptor Gene Cluster in Human Phagocytes

1994 ◽  
Vol 201 (1) ◽  
pp. 174-179 ◽  
Author(s):  
M. Durstin ◽  
J.L. Gao ◽  
H.L. Tiffany ◽  
D. Mcdermott ◽  
P.M. Murphy
Keyword(s):  
Differential Expression ◽  
Gene Cluster ◽  
Receptor Gene ◽  
Formylpeptide Receptor

Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness

2002 ◽  
Vol 11 (2) ◽  
pp. 65-72 ◽  
Author(s):  
Imran M. Khan ◽  
Erin Singletary ◽  
Adamu Alemayehu ◽  
Shanaka Stanislaus ◽  
Morton P. Printz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Gene Cluster ◽  
Nicotinic Receptor ◽  
Receptor Gene ◽  
Repeated Administration ◽  
Chromosome 8 ◽  
Brown Norway ◽  
Spontaneously Hypertensive ◽  
Nicotinic Agonists ◽  
Nociceptive Responses

Spontaneously hypertensive rats (SHR) exhibit enhanced pressor, heart rate, and nociceptive responses to spinal nicotinic agonists. This accompanies a paradoxical decrease in spinal nicotinic receptor number in SHR compared with normotensive rats. The congenic strain, SHR-Lx, with an introgressed chromosome 8 segment from the normotensive Brown-Norway-Lx strain (BN-Lx) exhibits reduced blood pressure. This segment contains a gene cluster for three nicotinic receptor subunits expressed in the nervous system. We examined the implication of this gene cluster in the enhanced responsiveness of the SHR. Pressor and nociceptive responses to spinal cytisine, a nicotinic agonist, were diminished in SHR-Lx. Moreover, with repeated administration, these responses desensitized faster in SHR-Lx and progenitor BN-Lx than in progenitor SHR/Ola. This implicates the gene cluster in both cardiovascular and nociceptive responses to spinal nicotinic agonists. Since diminished responsiveness to agonist stimulation is greater than the basal blood pressure differences between the strains and the introgressed rat chromosome maps to a quantitative trait locus in human hypertension, polymorphisms in the three nicotinic receptor genes become candidates for altered central control of blood pressure.

scholarly journals Gene cluster lock after pheromone receptor gene choice

2007 ◽  
Vol 26 (14) ◽  
pp. 3423-3430 ◽  
Author(s):  
Daniele Roppolo ◽  
Sarah Vollery ◽  
Chen-Da Kan ◽  
Christian Lüscher ◽  
Marie-Christine Broillet ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Receptor Gene ◽  
Pheromone Receptor

scholarly journals Evolutionary Story of the Low/Medium-Affinity IgG Fc Receptor Gene Cluster

2019 ◽  
Vol 10 ◽  
Author(s):  
Julien Lejeune ◽  
Guillaume Brachet ◽  
Hervé Watier
Keyword(s):  
Gene Cluster ◽  
Receptor Gene ◽  
Fc Receptor ◽  
Evolutionary Story

The Killer Immunoglobulin-Like Receptor Gene Cluster: Tuning the Genome for Defense

2006 ◽  
Vol 7 (1) ◽  
pp. 277-300 ◽  
Author(s):  
Arman A. Bashirova ◽  
Maureen P. Martin ◽  
Daniel W. McVicar ◽  
Mary Carrington
Keyword(s):  
Gene Cluster ◽  
Receptor Gene

scholarly journals Molecular evolution of the human interleukin–8 receptor gene cluster

1992 ◽  
Vol 2 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Sunil K. Ahuja ◽  
Tayfun Özçelik ◽  
Athena Milatovitch ◽  
Uta Francke ◽  
Philip M. Murphy
Keyword(s):  
Molecular Evolution ◽  
Gene Cluster ◽  
Receptor Gene ◽  
Interleukin 8
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