Do C-reactive protein levels help predict onset of rheumatoid arthritis in women?

2007 ◽  
Vol 3 (6) ◽  
pp. 318-319
Author(s):  
Dirkjan van Schaardenburg ◽  
Gertjan Wolbink ◽  
Michael T Nurmohamed ◽  
Bernardus AC Dijkmans
Keyword(s):  
Rheumatoid Arthritis ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 691
Author(s):  
Alma D. Del Angel-Pablo ◽  
Ivette Buendía-Roldán ◽  
Mayra Mejía ◽  
Gloria Pérez-Rubio ◽  
Karol J. Nava-Quiroz ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Class Ii ◽  
Hla Class Ii ◽  
C Reactive Protein ◽  
Hla Antibodies ◽  
Protein Levels ◽  
Reactive Protein ◽  
Genetic And Environmental Factors

The pathogenesis of Rheumatoid Arthritis (RA) is not fully understood, probably influenced by genetic and environmental factors. Interstitial Lung Disease (ILD) is an extra-articular manifestation of RA, which contributes significantly to morbidity and mortality. The identification of anti-HLA antibodies has been useful in the transplantation field; however, its contribution to autoimmune diseases as RA has not been fully studied. We aimed to determine the presence of anti-HLA antibodies in RA patients with and without ILD and its possible association with clinical and biochemical markers. One-hundred and forty-seven RA patients, of which 65 had ILD (RA-ILD group), were included. Sera samples for Anti-HLA Class II LABScreen panel-reactive antibodies (PRA) were analyzed. In both groups, women predominated, and lung function was worse in patients with ILD. The anti-CCP+ (UI/mL) was higher in the RA group in comparison to RA-ILD (p < 0.001). Expositional risk factors (tobacco smoking and biomass-burning smoke) were higher in RA-ILD patients. PRA+ was identified in ~25% RA-ILD patients, while ~29% in the RA group. The CRP levels have a positive correlation with the percentage of reactivity (%PRA, p = 0.02, r2 = 0.60) in the RA-ILD group. In conclusion, anti-HLA antibodies correlate with C-reactive protein levels in RA patients with ILD.

scholarly journals Relationship between time-integrated C-reactive protein levels and radiologic progression in patients with rheumatoid arthritis

2000 ◽  
Vol 43 (7) ◽  
pp. 1473-1477 ◽  
Author(s):  
Michael J. Plant ◽  
Arnold L. Williams ◽  
Margaret M. O'Sullivan ◽  
Peter A. Lewis ◽  
Edward C. Coles ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Radiologic Progression
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