scholarly journals Relationship between serum trough infliximab levels, pretreatment C reactive protein levels, and clinical response to infliximab treatment in patients with rheumatoid arthritis

2005 ◽  
Vol 64 (5) ◽  
pp. 704-707 ◽  
Author(s):  
G J Wolbink
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Response ◽  
Infliximab Treatment ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Serum Trough

scholarly journals Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 691
Author(s):  
Alma D. Del Angel-Pablo ◽  
Ivette Buendía-Roldán ◽  
Mayra Mejía ◽  
Gloria Pérez-Rubio ◽  
Karol J. Nava-Quiroz ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Class Ii ◽  
Hla Class Ii ◽  
C Reactive Protein ◽  
Hla Antibodies ◽  
Protein Levels ◽  
Reactive Protein ◽  
Genetic And Environmental Factors

The pathogenesis of Rheumatoid Arthritis (RA) is not fully understood, probably influenced by genetic and environmental factors. Interstitial Lung Disease (ILD) is an extra-articular manifestation of RA, which contributes significantly to morbidity and mortality. The identification of anti-HLA antibodies has been useful in the transplantation field; however, its contribution to autoimmune diseases as RA has not been fully studied. We aimed to determine the presence of anti-HLA antibodies in RA patients with and without ILD and its possible association with clinical and biochemical markers. One-hundred and forty-seven RA patients, of which 65 had ILD (RA-ILD group), were included. Sera samples for Anti-HLA Class II LABScreen panel-reactive antibodies (PRA) were analyzed. In both groups, women predominated, and lung function was worse in patients with ILD. The anti-CCP+ (UI/mL) was higher in the RA group in comparison to RA-ILD (p < 0.001). Expositional risk factors (tobacco smoking and biomass-burning smoke) were higher in RA-ILD patients. PRA+ was identified in ~25% RA-ILD patients, while ~29% in the RA group. The CRP levels have a positive correlation with the percentage of reactivity (%PRA, p = 0.02, r2 = 0.60) in the RA-ILD group. In conclusion, anti-HLA antibodies correlate with C-reactive protein levels in RA patients with ILD.

scholarly journals Relationship between time-integrated C-reactive protein levels and radiologic progression in patients with rheumatoid arthritis

2000 ◽  
Vol 43 (7) ◽  
pp. 1473-1477 ◽  
Author(s):  
Michael J. Plant ◽  
Arnold L. Williams ◽  
Margaret M. O'Sullivan ◽  
Peter A. Lewis ◽  
Edward C. Coles ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Radiologic Progression

scholarly journals Clinical Response and Complications are not Associated with Drug Levels in Patients with Severe Ulcerative Colitis on IV Cyclosporine Induction Therapy

2018 ◽  
Vol 24 (6) ◽  
pp. 1291-1297 ◽  
Author(s):  
Parita Patel ◽  
Andres Yarur ◽  
Sushila Dalal ◽  
Atsuhi Sakuraba ◽  
David T Rubin ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Postoperative Complications ◽  
Clinical Response ◽  
Induction Therapy ◽  
Kidney Injury ◽  
C Reactive Protein ◽  
Drug Levels ◽  
Protein Levels ◽  
Reactive Protein ◽  
Steroid Refractory

Abstract Background IV ciclosporin therapy is effective in steroid-refractory ulcerative colitis. The optimal drug level to achieve response and minimize complications during induction therapy is not known. Aim The primary aim was to evaluate if serum ciclosporin drug levels are associated with increased risk of colectomy within 90 days of hospitalization. Secondary aims were to determine if ciclosporin levels are associated with avoidance of colectomy at 7 and 30 days, if ciclosporin levels are associated with drug-related and postoperative complications, and if patient-specific factors are associated with response to ciclosporin. Methods We conducted a retrospective analysis of 81 hospitalized patients with steroid-refractory ulcerative colitis treated with ciclosporin. Risk factors for colectomy within 7, 30, and 90 days, medication-specific and postoperative complications were compared by first, mean, and peak ciclosporin level during IV induction therapy. Results There were 47 patients (58%) who underwent surgery. There were no differences between initial, mean, and peak ciclosporin levels among responders and nonresponders and treatment-related or postoperative complications. Responders within 90 days had lower C-reactive-protein levels (20mg/L vs. 38mg/L, P = 0.01), lower serum albumin concentrations (3.4g/dL vs. 3.7g/dL, P = 0.03), and higher rates of kidney injury (50% vs 17%, P = 0.002). Conclusion Initial, mean, and peak serum levels of ciclosporin did not correlate with response or toxicity. However, C-reactive-protein levels levels and kidney injury may be helpful in predicting clinical response to ciclosporin.

Do C-reactive protein levels help predict onset of rheumatoid arthritis in women?

2007 ◽  
Vol 3 (6) ◽  
pp. 318-319
Author(s):  
Dirkjan van Schaardenburg ◽  
Gertjan Wolbink ◽  
Michael T Nurmohamed ◽  
Bernardus AC Dijkmans
Keyword(s):  
Rheumatoid Arthritis ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein
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