scholarly journals The careg element reveals a common regulation of regeneration in the zebrafish myocardium and fin

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Catherine Pfefferli ◽  
Anna Jaźwińska
Keyword(s):  
Regulation Of Regeneration

scholarly journals Regeneration linked miRNA modify tumor phenotype and can enforce multi-lineage growth arrest in vivo

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Siamak Salehi ◽  
Oliver D. Tavabie ◽  
Augusto Villanueva ◽  
Julie Watson ◽  
David Darling ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Growth Inhibition ◽  
Tumor Aggressiveness ◽  
Novel Treatment ◽  
Tumor Phenotype ◽  
Aggressive Tumor ◽  
In Vivo Growth ◽  
Regulation Of Regeneration

AbstractRegulated cell proliferation is an effector mechanism of regeneration, whilst dysregulated cell proliferation is a feature of cancer. We have previously identified microRNA (miRNA) that regulate successful and failed human liver regeneration. We hypothesized that these regulators may directly modify tumor behavior. Here we show that inhibition of miRNAs -503 and -23a, alone or in combination, enhances tumor proliferation in hepatocyte and non-hepatocyte derived cancers in vitro, driving more aggressive tumor behavior in vivo. Inhibition of miRNA-152 caused induction of DNMT1, site-specific methylation with associated changes in gene expression and in vitro and in vivo growth inhibition. Enforced changes in expression of two miRNA recapitulating changes observed in failed regeneration led to complete growth inhibition of multi-lineage cancers in vivo. Our results indicate that regulation of regeneration and tumor aggressiveness are concordant and that miRNA-based inhibitors of regeneration may constitute a novel treatment strategy for human cancers.

scholarly journals Organ Regeneration on Excised Roots of Chondrilla Juncea and Its Chemical Regulation

1972 ◽  
Vol 25 (4) ◽  
pp. 691 ◽  
Author(s):  
NP Kefford ◽  
OH Caso
Keyword(s):  
Root Formation ◽  
Bud Formation ◽  
Endogenous Factors ◽  
Chemical Regulation ◽  
Synthetic Auxins ◽  
Organ Regeneration ◽  
Low Concentrations ◽  
Standard Assay ◽  
Gibberellin Treatment ◽  
Regulation Of Regeneration

The effects of endogenous factors (plant age, section length, and section location) and environmental factors (temperature and mineral nutrition) upon organ regeneration on isolated root sections of Ohondrilla juncea L. were used to develop a standard assay system for the study of the chemical regulation of regeneration. Bud and root formation and its polarity in the presence of a variety of regulators alone and in combinations were observed quantitatively. Bud numbers were increased by auxin (low concentrations), cytokinin, and gibberellin treatments. High concentra� tions of auxin inhibited bud formation and this effect was reversed by antiauxin, cytokinin, or gibberellin. Adenine did not counteract auxin� induced bud inhibition but adenine and N�6�benzyladenine did counteract inhibition induced by the purine antagonist 2,6�diaminopurine. Numbers of regenerated roots were increased by auxin treatment and reduced by cytokinin and gibberellin treatment. On control and auxin� treated sections, bud formation was strongly polar and proximal and cytokinin and gibberellin treatments lessened the polarity. Growth retardants inhibited regeneration. Of a number of synthetic auxins tested, 2,4.dichlorophenoxy. acet.O.methylhydroxamic acid and 4�amino.3,5,6.trichloropicolinic acid were the most effective inhibitors of bud formation.

scholarly journals Endocrine Regulation of Epimorphic Regeneration

Endocrinology ◽  
2019 ◽  
Vol 160 (12) ◽  
pp. 2969-2980 ◽  
Author(s):  
Marietta R Easterling ◽  
Kristin M Engbrecht ◽  
Erica J Crespi
Keyword(s):  
Physiological State ◽  
Future Research ◽  
Endocrine Regulation ◽  
Epimorphic Regeneration ◽  
Blastema Formation ◽  
Proliferation And Differentiation ◽  
Cumulative Knowledge ◽  
Differentiation Pathways ◽  
Regulation Of Regeneration

Abstract Studies aiming to uncover primary mechanisms of regeneration have predominantly focused on genetic pathways regulating specific stages in the regeneration process: wound healing, blastema formation, and pattern formation. However, studies across organisms show that environmental conditions and the physiological state of the animal can affect the rate or quality of regeneration, and endocrine signals are likely the mediators of these effects. Endocrine signals acting directly on receptors expressed in the tissue or via neuroendocrine pathways can affect regeneration by regulating the immune response to injury, allocation of energetic resources, or by enhancing or inhibiting proliferation and differentiation pathways involved in regeneration. This review discusses the cumulative knowledge in the literature about endocrine regulation of regeneration and its importance in future research to advance biomedical research.

scholarly journals On the possible role of serotonin in the regulation of regeneration of cilia.

1980 ◽  
Vol 85 (2) ◽  
pp. 242-247 ◽  
Author(s):  
N Rodríguez ◽  
F L Renaud
Keyword(s):  
Calcium Ions ◽  
Tetrahymena Pyriformis ◽  
Intracellular Concentration ◽  
Causal Relationships ◽  
Serotonin Synthesis ◽  
High Concentrations ◽  
Regulation Of Regeneration

A study was made of the interrelationship of serotonin, cAMP, and calcium ions in the regulation of regeneration of cilia by Tetrahymena pyriformis. All these compounds stimulated the regeneration, whereas a blocker of serotonin synthesis, p-chlorophenylalanine, and a calcium chelator, EGTA, inhibited the process. This inhibition could be overcome by the addition of any of the stimulatory compounds. cAMP was also found to be inhibitory at high concentrations. The intracellular concentration of this nucleotide was found to increase during the regeneration, and this increase occurred precociously in the presence of serotonin. It was concluded that serotonin may regulate ciliary regeneration by a mechanism involving cAMP And calcium ions, but that the causal relationships among these compounds still need to be established.

scholarly journals Circadian Regulation in Tissue Regeneration

2019 ◽  
Vol 20 (9) ◽  
pp. 2263 ◽  
Author(s):  
Ellen Paatela ◽  
Dane Munson ◽  
Nobuaki Kikyo
Keyword(s):  
Tissue Regeneration ◽  
Molecular Mechanisms ◽  
Cell Types ◽  
The Body ◽  
Circadian Regulation ◽  
Global Regulator ◽  
Protein Coding ◽  
Translational Activity ◽  
Regenerative Therapies ◽  
Regulation Of Regeneration

Circadian rhythms regulate over 40% of protein-coding genes in at least one organ in the body through mechanisms tied to the central circadian clock and to cell-intrinsic auto-regulatory feedback loops. Distinct diurnal differences in regulation of regeneration have been found in several organs, including skin, intestinal, and hematopoietic systems. Each regenerating system contains a complex network of cell types with different circadian mechanisms contributing to regeneration. In this review, we elucidate circadian regeneration mechanisms in the three representative systems. We also suggest circadian regulation of global translational activity as an understudied global regulator of regenerative capacity. A more detailed understanding of the molecular mechanisms underlying circadian regulation of tissue regeneration would accelerate the development of new regenerative therapies.

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