Humoral regulation of regeneration in the lungs, kidneys, and liver

1972 ◽  
Vol 73 (1) ◽  
pp. 84-87 ◽  
Author(s):  
L. K. Romanova ◽  
I. A. Zhikhareva
Keyword(s):  
Regulation Of Regeneration ◽  
Humoral Regulation

scholarly journals Regeneration linked miRNA modify tumor phenotype and can enforce multi-lineage growth arrest in vivo

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Siamak Salehi ◽  
Oliver D. Tavabie ◽  
Augusto Villanueva ◽  
Julie Watson ◽  
David Darling ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Growth Inhibition ◽  
Tumor Aggressiveness ◽  
Novel Treatment ◽  
Tumor Phenotype ◽  
Aggressive Tumor ◽  
In Vivo Growth ◽  
Regulation Of Regeneration

AbstractRegulated cell proliferation is an effector mechanism of regeneration, whilst dysregulated cell proliferation is a feature of cancer. We have previously identified microRNA (miRNA) that regulate successful and failed human liver regeneration. We hypothesized that these regulators may directly modify tumor behavior. Here we show that inhibition of miRNAs -503 and -23a, alone or in combination, enhances tumor proliferation in hepatocyte and non-hepatocyte derived cancers in vitro, driving more aggressive tumor behavior in vivo. Inhibition of miRNA-152 caused induction of DNMT1, site-specific methylation with associated changes in gene expression and in vitro and in vivo growth inhibition. Enforced changes in expression of two miRNA recapitulating changes observed in failed regeneration led to complete growth inhibition of multi-lineage cancers in vivo. Our results indicate that regulation of regeneration and tumor aggressiveness are concordant and that miRNA-based inhibitors of regeneration may constitute a novel treatment strategy for human cancers.

scholarly journals Organ Regeneration on Excised Roots of Chondrilla Juncea and Its Chemical Regulation

1972 ◽  
Vol 25 (4) ◽  
pp. 691 ◽  
Author(s):  
NP Kefford ◽  
OH Caso
Keyword(s):  
Root Formation ◽  
Bud Formation ◽  
Endogenous Factors ◽  
Chemical Regulation ◽  
Synthetic Auxins ◽  
Organ Regeneration ◽  
Low Concentrations ◽  
Standard Assay ◽  
Gibberellin Treatment ◽  
Regulation Of Regeneration

The effects of endogenous factors (plant age, section length, and section location) and environmental factors (temperature and mineral nutrition) upon organ regeneration on isolated root sections of Ohondrilla juncea L. were used to develop a standard assay system for the study of the chemical regulation of regeneration. Bud and root formation and its polarity in the presence of a variety of regulators alone and in combinations were observed quantitatively. Bud numbers were increased by auxin (low concentrations), cytokinin, and gibberellin treatments. High concentra� tions of auxin inhibited bud formation and this effect was reversed by antiauxin, cytokinin, or gibberellin. Adenine did not counteract auxin� induced bud inhibition but adenine and N�6�benzyladenine did counteract inhibition induced by the purine antagonist 2,6�diaminopurine. Numbers of regenerated roots were increased by auxin treatment and reduced by cytokinin and gibberellin treatment. On control and auxin� treated sections, bud formation was strongly polar and proximal and cytokinin and gibberellin treatments lessened the polarity. Growth retardants inhibited regeneration. Of a number of synthetic auxins tested, 2,4.dichlorophenoxy. acet.O.methylhydroxamic acid and 4�amino.3,5,6.trichloropicolinic acid were the most effective inhibitors of bud formation.

scholarly journals Humoral Regulation of Iron Absorption

1969 ◽  
Vol 57 (2) ◽  
pp. 225-228 ◽  
Author(s):  
Marcel E. Conrad ◽  
M.C. Colonel
Keyword(s):  
Iron Absorption ◽  
Humoral Regulation

scholarly journals Humoral regulation of neuromuscular transmission and neurotrophic control of skeletal muscle fiber

2001 ◽  
Vol 82 (5) ◽  
pp. 321-325
Author(s):  
G. I. Poletaev
Keyword(s):  
Skeletal Muscle ◽  
Nervous System ◽  
Muscle Fiber ◽  
Neuromuscular Transmission ◽  
Chemical Nature ◽  
Focus Of Attention ◽  
Skeletal Muscle Fiber ◽  
Neurotrophic Control ◽  
First Time ◽  
Humoral Regulation

The mechanism of nerve-to-muscle transmission, as well as the trophic influence of the nervous system on effector organs, have always been in the focus of attention of scientists of the Kazan physiological school. Suffice it to recall the famous physiologist A.F. Samoilov, who in 1924 for the first time established the chemical nature of neuromuscular transmission.

Humoral Regulation of Breathing

Science ◽  
1961 ◽  
Vol 134 (3482) ◽  
pp. 884-884
Author(s):  
Albert Roos ◽  
Thomas F. Hornbein
Keyword(s):  
Regulation Of Breathing ◽  
Humoral Regulation
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