scholarly journals A three-dimensional model of human lung development and disease from pluripotent stem cells

2017 ◽  
Vol 19 (5) ◽  
pp. 542-549 ◽  
Author(s):  
Ya-Wen Chen ◽  
Sarah Xuelian Huang ◽  
Ana Luisa Rodrigues Toste de Carvalho ◽  
Siu-Hong Ho ◽  
Mohammad Naimul Islam ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Lung Development ◽  
Human Lung ◽  
Three Dimensional ◽  
Dimensional Model ◽  
Three Dimensional Model

scholarly journals Organoide

2020 ◽  
Keyword(s):  
Stem Cells ◽  
Interdisciplinary Research ◽  
Three Dimensional ◽  
Model Systems ◽  
Gene Technology ◽  
Dimensional Model ◽  
Three Dimensional Model ◽  
Legal Questions ◽  
Wide Debate ◽  
Academy Of Sciences

Organoids are developed from stem cells and serve as three-dimensional model systems for different organs. They have great potential for research and medicine, but also raise philosophical, ethical and legal questions which have rarely been discussed in Germany so far. This thematic study by the interdisciplinary research group (IAG) Gene Technology Report at the Berlin-Brandenburg Academy of Sciences and Humanities offers an overview of current scientific developments, their present and potential application, as well as epistemological, ethical and legal reflections. Hereby, the IAG wants to provide impetus for an interdisciplinary and society-wide debate on this general subject. With contributions by Cantas Alev, Aileen-Diane Bamford, Sina Bartfeld, Andreia S. Batista-Rocha, Ali H. Brivanlou, Thomas Burgold, Cindrilla Chumduri, Stephan Clemens, Emrecan Dilmen, Tobias Erb, Fred Etoc, Melinda B. Fagan, Heiner Fangerau, Boris Fehse, Nina Frey, Tristan Frum, Anne Grapin-Botton, Navin Gupta, Jürgen Hampel, Ferdinand Hucho, Özge Kayisoglu, Rashmiparvathi Keshara, Yung Hae Kim, Bon-Kyoung Koo, Martin Korte, Yaroslav Koshelev, Kai Kretzschmar, Allison Lewis, Lilian Marx-Stölting, Fruzsina Molnár-Gábor, Ryuji Morizane, Stefan Mundlos, Paola Nicolas, Angela Osterheider, In-Hyun Park, Anja Pichl, Sandra Pilat-Carotta, Jens Reich, Marlen Reinschke, Hannah Schickl, Silke Schicktanz, Nicolas Schlegel, Jason R. Spence, Yoshiaki Tanaka, Jochen Taupitz, Isaree Teriyapirom, Margherita Y. Turco, Jörn Walter, Eva Winkler, Martin Zenke.

scholarly journals Use of three-dimensional organoids and lung-on-a-chip methods to study lung development, regeneration and disease

2018 ◽  
Vol 52 (5) ◽  
pp. 1800876 ◽  
Author(s):  
Konstantinos Gkatzis ◽  
Sara Taghizadeh ◽  
Dongeun Huh ◽  
Didier Y.R. Stainier ◽  
Saverio Bellusci
Keyword(s):  
Pluripotent Stem Cells ◽  
Lung Development ◽  
Animal Studies ◽  
Human Lung ◽  
Unmet Need ◽  
Three Dimensional ◽  
Lung Cells ◽  
Lung Physiology ◽  
And Function

Differences in lung anatomy between mice and humans, as well as frequently disappointing results when using animal models for drug discovery, emphasise the unmet need for in vitro models that can complement animal studies and improve our understanding of human lung physiology, regeneration and disease. Recent papers have highlighted the use of three-dimensional organoids and organs-on-a-chip to mimic tissue morphogenesis and function in vitro. Here, we focus on the respiratory system and provide an overview of these in vitro models, which can be derived from primary lung cells and pluripotent stem cells, as well as healthy or diseased lungs. We emphasise their potential application in studies of respiratory development, regeneration and disease modelling.

scholarly journals A Three-Dimensional Model of Human Lung Airway Tree to Study Therapeutics Delivery in the Lungs

2019 ◽  
Vol 47 (6) ◽  
pp. 1435-1445
Author(s):  
Antonio Copploe ◽  
Morteza Vatani ◽  
Jae-Won Choi ◽  
Hossein Tavana
Keyword(s):  
Human Lung ◽  
Three Dimensional ◽  
Dimensional Model ◽  
Three Dimensional Model ◽  
Airway Tree
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