scholarly journals Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment

2016 ◽  
Vol 29 (5) ◽  
pp. 528-541 ◽  
Author(s):  
Kenneth Friedman ◽  
Alexander S Brodsky ◽  
Shaolei Lu ◽  
Stephanie Wood ◽  
Anthony J Gill ◽  
...  
Keyword(s):  
Medullary Carcinoma ◽  
Carcinoma Of The Colon ◽  
Distinct Morphology

scholarly journals Medullary Carcinoma of the Colon: A Histopathologic Challenge

Cureus ◽  
2021 ◽  
Author(s):  
Zainab Fatima ◽  
Purva Sharma ◽  
Bahaaeldin Youssef ◽  
Koyamangalath Krishnan
Keyword(s):  
Medullary Carcinoma ◽  
Carcinoma Of The Colon

scholarly journals Medullary Carcinoma of the Gastrointestinal Tract: Report on Two Cases with Immunohistochemical and Molecular Features

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1775
Author(s):  
Cristina Colarossi ◽  
Marzia Mare ◽  
Giorgio La Greca ◽  
Marco De Zuanni ◽  
Lorenzo Colarossi ◽  
...  
Keyword(s):  
Older Women ◽  
Specific Treatment ◽  
Medullary Carcinoma ◽  
Good Prognosis ◽  
Right Colon ◽  
Carcinoma Of The Colon ◽  
Molecular Features ◽  
Histological Variant ◽  
Poorly Differentiated ◽  
The Right

Medullary carcinoma of the colon is a rare histological variant characterized by a poorly differentiated morphology, an aberrant immunophenotype, and microsatellite instability. Despite the lack of glandular differentiation, medullary carcinoma is reported to have a good prognosis. It is typically located in the right colon and frequently affects older women. Due to its clinical, histological, biological, and genetic peculiarity, medullary carcinoma requires an accurate diagnosis and the awareness of this diagnostic possibility. We describe the morphological, immunohistochemical, and molecular findings of two interesting cases, the first one in the right colon of a patient and the second one in the terminal ileum of a patient with Crohn’s disease. Deeper knowledge of all the biological and clinical features will allow appropriate and specific treatment of this tumor in the future.

scholarly journals Microsatellite Instability in Medullary Carcinoma of the Colon

Rare Tumors ◽  
2016 ◽  
Vol 9 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Mario Martinotti ◽  
Fernando Cirillo ◽  
Marco Ungari ◽  
Giulia Tanzi ◽  
Giovanni Rolando ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Medullary Carcinoma ◽  
Good Health ◽  
Caucasian Woman ◽  
Poorly Differentiated Adenocarcinoma ◽  
Carcinoma Of The Colon ◽  
Stenotic Lesion ◽  
Dna Mismatch ◽  
Poorly Differentiated

Medullary carcinoma (MC) of the large intestine is a relatively new histological type of adenocarcinoma characterized by poor glandular differentiation and an intraepithelial lymphocytic infiltrate. MC can be associated to a defective mechanism for DNA mismatch repair, caused by the so-called microsatellite instability (MSI). We present the case of a 44 years old Caucasian woman, who referred to the Emergency Room with symptoms mimicking an acute appendicitis. Computed tomography and colonoscopy demonstrated an ulcerated and stenotic lesion of the caecum without signs of metastasis and peritoneal carcinosis. Patient underwent a laparoscopic right colectomy. The final pathologic findings provided the diagnosis of medullary carcinoma with MSI. Patient then underwent adjuvant chemotherapy according to the FOLFOX-4 protocol (association of 5-Fluorouracil, Leucovorin, and Oxaliplatin) for twelve cycles. At two-years follow-up, patient is disease free. MC in association with MSI is a non-frequent tumor of the colon characterized by a better prognosis compared to other types of poorly differentiated adenocarcinoma. In the observed case, 24 months after the surgical operation, the patient is in good health and there is no evidence of metastasis or relapse.

Medullary carcinoma of the colon: can the undifferentiated be differentiated?

2014 ◽  
Vol 466 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Anne-Marie Kanstrup Fiehn ◽  
Morten Grauslund ◽  
Anders Glenthøj ◽  
Linea Cecilie Melchior ◽  
Ben Vainer ◽  
...  
Keyword(s):  
Medullary Carcinoma ◽  
Carcinoma Of The Colon

scholarly journals S1656 Not Your Standard Adenocarcinoma, a Case of Medullary Carcinoma of the Colon

2020 ◽  
Vol 115 (1) ◽  
pp. S850-S850
Author(s):  
Paul Gomez ◽  
Elizabeth Rowland ◽  
Nael Haddad ◽  
Anam Omer ◽  
Paul Muna-Aguon ◽  
...  
Keyword(s):  
Medullary Carcinoma ◽  
Carcinoma Of The Colon

scholarly journals Sporadic Medullary Carcinoma of the Colon

2005 ◽  
Vol 123 (1) ◽  
pp. 56-65 ◽  
Author(s):  
Mark R. Wick ◽  
Jon L. Vitsky ◽  
Jon H. Ritter ◽  
Paul E. Swanson ◽  
Stacey E. Mills
Keyword(s):  
Medullary Carcinoma ◽  
Carcinoma Of The Colon
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