Is Medullary Carcinoma of the Colon Underdiagnosed ? An Audit of Poorly Differentiated Colorectal Carcinomas in a large NHS Teaching Hospital.

2020 ◽  
Author(s):  
N Scott ◽  
NP West ◽  
A Cairns ◽  
O Rotimi
Keyword(s):  
Teaching Hospital ◽  
Medullary Carcinoma ◽  
Colorectal Carcinomas ◽  
Carcinoma Of The Colon ◽  
Poorly Differentiated

scholarly journals Medullary Carcinoma of the Gastrointestinal Tract: Report on Two Cases with Immunohistochemical and Molecular Features

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1775
Author(s):  
Cristina Colarossi ◽  
Marzia Mare ◽  
Giorgio La Greca ◽  
Marco De Zuanni ◽  
Lorenzo Colarossi ◽  
...  
Keyword(s):  
Older Women ◽  
Specific Treatment ◽  
Medullary Carcinoma ◽  
Good Prognosis ◽  
Right Colon ◽  
Carcinoma Of The Colon ◽  
Molecular Features ◽  
Histological Variant ◽  
Poorly Differentiated ◽  
The Right

Medullary carcinoma of the colon is a rare histological variant characterized by a poorly differentiated morphology, an aberrant immunophenotype, and microsatellite instability. Despite the lack of glandular differentiation, medullary carcinoma is reported to have a good prognosis. It is typically located in the right colon and frequently affects older women. Due to its clinical, histological, biological, and genetic peculiarity, medullary carcinoma requires an accurate diagnosis and the awareness of this diagnostic possibility. We describe the morphological, immunohistochemical, and molecular findings of two interesting cases, the first one in the right colon of a patient and the second one in the terminal ileum of a patient with Crohn’s disease. Deeper knowledge of all the biological and clinical features will allow appropriate and specific treatment of this tumor in the future.

scholarly journals Microsatellite Instability in Medullary Carcinoma of the Colon

Rare Tumors ◽  
2016 ◽  
Vol 9 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Mario Martinotti ◽  
Fernando Cirillo ◽  
Marco Ungari ◽  
Giulia Tanzi ◽  
Giovanni Rolando ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Medullary Carcinoma ◽  
Good Health ◽  
Caucasian Woman ◽  
Poorly Differentiated Adenocarcinoma ◽  
Carcinoma Of The Colon ◽  
Stenotic Lesion ◽  
Dna Mismatch ◽  
Poorly Differentiated

Medullary carcinoma (MC) of the large intestine is a relatively new histological type of adenocarcinoma characterized by poor glandular differentiation and an intraepithelial lymphocytic infiltrate. MC can be associated to a defective mechanism for DNA mismatch repair, caused by the so-called microsatellite instability (MSI). We present the case of a 44 years old Caucasian woman, who referred to the Emergency Room with symptoms mimicking an acute appendicitis. Computed tomography and colonoscopy demonstrated an ulcerated and stenotic lesion of the caecum without signs of metastasis and peritoneal carcinosis. Patient underwent a laparoscopic right colectomy. The final pathologic findings provided the diagnosis of medullary carcinoma with MSI. Patient then underwent adjuvant chemotherapy according to the FOLFOX-4 protocol (association of 5-Fluorouracil, Leucovorin, and Oxaliplatin) for twelve cycles. At two-years follow-up, patient is disease free. MC in association with MSI is a non-frequent tumor of the colon characterized by a better prognosis compared to other types of poorly differentiated adenocarcinoma. In the observed case, 24 months after the surgical operation, the patient is in good health and there is no evidence of metastasis or relapse.

scholarly journals A RARE CASE STUDY OF MEDULLARY CARCINOMA OF DESCENDING COLON REPORTED ON HISTOPATHOLOGY

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Rajvala Choudhary ◽  
Chandrika Gupta ◽  
Lakhami Chand Sinsinwar ◽  
Sapna Shrivastava ◽  
Sanjeev Singh Choudhary
Keyword(s):  
Strong Association ◽  
Medullary Carcinoma ◽  
Interesting Case ◽  
World Health ◽  
Histologic Subtype ◽  
Undifferentiated Adenocarcinoma ◽  
Poorly Differentiated ◽  
Carcinoma Of Colon ◽  
Health Organization ◽  
Deficient Mismatch Repair

Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer whichcharacterized by poor glandular differentiation and intraepithelial lymphocytic infiltrate. This has now been incorporated as a separate entity in the World Health Organization (WHO) classification of colorectal cancers.It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on pathology seen in colorectal adenocarcinoma. Here, we discuss an interesting case of MC of the colon that was metastatic on presentation and constituted a diagnostic challenge1. Keywords: medullary carcinoma, colorectal carcinomas (CRC), medullary carcinoma of colon,poorly differentiated adenocarcinoma, undifferentiated adenocarcinoma.

scholarly journals Expression of the intestinal biomarkers Guanylyl cyclase C and CDX2 in poorly differentiated colorectal carcinomas

2010 ◽  
Vol 41 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Brody Winn ◽  
Rosemarie Tavares ◽  
Andres Matoso ◽  
Lelia Noble ◽  
Jacqueline Fanion ◽  
...  
Keyword(s):  
Guanylyl Cyclase ◽  
Guanylyl Cyclase C ◽  
Colorectal Carcinomas ◽  
Poorly Differentiated

Angiogenesis in poorly differentiated medullary carcinoma of the stomach

Surgery Today ◽  
1998 ◽  
Vol 28 (4) ◽  
pp. 367-372 ◽  
Author(s):  
Yutaka Takahashi ◽  
Lee M. Ellis ◽  
Takahito Ohta ◽  
Masayoshi Mai
Keyword(s):  
Medullary Carcinoma ◽  
Carcinoma Of The Stomach ◽  
Poorly Differentiated

Ultrastructural study of poorly differentiated medullary carcinoma of the thyroid

1987 ◽  
Vol 410 (5) ◽  
pp. 455-460 ◽  
Author(s):  
Kennichi Kakudo ◽  
Akira Miyauchi ◽  
Shoichi Katayama ◽  
Keiichi Watanabe
Keyword(s):  
Ultrastructural Study ◽  
Medullary Carcinoma ◽  
Poorly Differentiated

scholarly journals CLINICOPATHOLOGICAL STUDY OF POORLY DIFFERENTIATED ADENOCARCINOMA AND MUCINOUS CARCINOMA OF THE COLON

1993 ◽  
Vol 43 (2) ◽  
pp. 147-152
Author(s):  
TOMIO SAWADA ◽  
SUSUMU OHWADA ◽  
IZUMI TAKEYOSHI ◽  
SEIJI NAKAMURA ◽  
YUKIO MIYAMOTO ◽  
...  
Keyword(s):  
Mucinous Carcinoma ◽  
Poorly Differentiated Adenocarcinoma ◽  
Carcinoma Of The Colon ◽  
Clinicopathological Study ◽  
Poorly Differentiated

scholarly journals Medullary Carcinoma of the Colon: A Histopathologic Challenge

Cureus ◽  
2021 ◽  
Author(s):  
Zainab Fatima ◽  
Purva Sharma ◽  
Bahaaeldin Youssef ◽  
Koyamangalath Krishnan
Keyword(s):  
Medullary Carcinoma ◽  
Carcinoma Of The Colon
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