scholarly journals Microsatellite Instability in Medullary Carcinoma of the Colon

Rare Tumors ◽  
2016 ◽  
Vol 9 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Mario Martinotti ◽  
Fernando Cirillo ◽  
Marco Ungari ◽  
Giulia Tanzi ◽  
Giovanni Rolando ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Medullary Carcinoma ◽  
Good Health ◽  
Caucasian Woman ◽  
Poorly Differentiated Adenocarcinoma ◽  
Carcinoma Of The Colon ◽  
Stenotic Lesion ◽  
Dna Mismatch ◽  
Poorly Differentiated

Medullary carcinoma (MC) of the large intestine is a relatively new histological type of adenocarcinoma characterized by poor glandular differentiation and an intraepithelial lymphocytic infiltrate. MC can be associated to a defective mechanism for DNA mismatch repair, caused by the so-called microsatellite instability (MSI). We present the case of a 44 years old Caucasian woman, who referred to the Emergency Room with symptoms mimicking an acute appendicitis. Computed tomography and colonoscopy demonstrated an ulcerated and stenotic lesion of the caecum without signs of metastasis and peritoneal carcinosis. Patient underwent a laparoscopic right colectomy. The final pathologic findings provided the diagnosis of medullary carcinoma with MSI. Patient then underwent adjuvant chemotherapy according to the FOLFOX-4 protocol (association of 5-Fluorouracil, Leucovorin, and Oxaliplatin) for twelve cycles. At two-years follow-up, patient is disease free. MC in association with MSI is a non-frequent tumor of the colon characterized by a better prognosis compared to other types of poorly differentiated adenocarcinoma. In the observed case, 24 months after the surgical operation, the patient is in good health and there is no evidence of metastasis or relapse.

scholarly journals CLINICOPATHOLOGICAL STUDY OF POORLY DIFFERENTIATED ADENOCARCINOMA AND MUCINOUS CARCINOMA OF THE COLON

1993 ◽  
Vol 43 (2) ◽  
pp. 147-152
Author(s):  
TOMIO SAWADA ◽  
SUSUMU OHWADA ◽  
IZUMI TAKEYOSHI ◽  
SEIJI NAKAMURA ◽  
YUKIO MIYAMOTO ◽  
...  
Keyword(s):  
Mucinous Carcinoma ◽  
Poorly Differentiated Adenocarcinoma ◽  
Carcinoma Of The Colon ◽  
Clinicopathological Study ◽  
Poorly Differentiated

scholarly journals Medullary Carcinoma of the Gastrointestinal Tract: Report on Two Cases with Immunohistochemical and Molecular Features

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1775
Author(s):  
Cristina Colarossi ◽  
Marzia Mare ◽  
Giorgio La Greca ◽  
Marco De Zuanni ◽  
Lorenzo Colarossi ◽  
...  
Keyword(s):  
Older Women ◽  
Specific Treatment ◽  
Medullary Carcinoma ◽  
Good Prognosis ◽  
Right Colon ◽  
Carcinoma Of The Colon ◽  
Molecular Features ◽  
Histological Variant ◽  
Poorly Differentiated ◽  
The Right

Medullary carcinoma of the colon is a rare histological variant characterized by a poorly differentiated morphology, an aberrant immunophenotype, and microsatellite instability. Despite the lack of glandular differentiation, medullary carcinoma is reported to have a good prognosis. It is typically located in the right colon and frequently affects older women. Due to its clinical, histological, biological, and genetic peculiarity, medullary carcinoma requires an accurate diagnosis and the awareness of this diagnostic possibility. We describe the morphological, immunohistochemical, and molecular findings of two interesting cases, the first one in the right colon of a patient and the second one in the terminal ileum of a patient with Crohn’s disease. Deeper knowledge of all the biological and clinical features will allow appropriate and specific treatment of this tumor in the future.

scholarly journals Prognostic significance of macrosatellite instability in patients under 50 years of age suffering from colorectal cancer

2009 ◽  
Vol 62 (5-6) ◽  
pp. 217-223
Author(s):  
Atila Fenjvesi
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Prognostic Significance ◽  
Young Patients ◽  
Dna Mismatch ◽  
Significant Difference ◽  
Sporadic Cases ◽  
Microsatellite Stability ◽  
Better Than

Introduction Colorectal cancer (CRC) can arise through two distinct mutational pathways: microsatellite instability or chromosomal instability. High-frequency microsatellite instability (MSI) occurs in approximately 15 percent of sporadic cases of CRCs. Many studies have well established that MSI, the hallmark of defective DNA mismatch repair, is associated with prolonged survival of CRC patients compared with tumors that are microsatellite stable. CRCs in patients under 50 years of age are rare and represent about 5% of the total number of tumors. The aim of this study was to analyze the prognostic significance of MSI in CRC patients younger than 50 at the time of diagnosis. Material and methods 31 patients with CRC under 50 years of age were tested for the presence of MSI, and compared with 35 patients aged 50 or more at the time of diagnosis. CRC-specific survival five-year- follow-up period was analyzed in relation to MSI status. Results The frequency of MSI among the young patients was 35.48%, which was significantly higher than the rate of 11.43% noted in older patients with CRCs (p<0.042). This study revealed no difference in survival in patients with CRCs aged less than 50 compared with those over 50 years of age. The five-years survival of young CRCs patients with MSI 81.82%, was better than that of the patients with cancers with microsatellite stability, 60%, but there was no significant difference in statistics. Discussion and conclusion In our study there was no statistically detectable significant difference between tumor microsatellite status and survival in young patients, although we confirmed the previous observations that MSI is associated with better prognosis. We found that the pathological stage of CRC was an independent and powerful predictor of the clinical outcome.

Various clinical outcomes in patients with esophageal or gastroesophageal junction (E-GEJ) adenocarcinoma undergoing trimodality therapy: Prognostic implications.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 120-120
Author(s):  
Akihiro Suzuki ◽  
Lianchun Xiao ◽  
Takashi Taketa ◽  
Kazuki Sudo ◽  
Mariela A. Blum ◽  
...  
Keyword(s):  
Pathological Complete Response ◽  
Gastroesophageal Junction ◽  
Complete Response ◽  
Trimodality Therapy ◽  
Poorly Differentiated Adenocarcinoma ◽  
Free Survival ◽  
Node Metastasis ◽  
Poorly Differentiated ◽  
Prognostic Implications

120 Background: Preoperative chemoradiation (trimodality therapy) has the strongest evidence in trimodality-eligible patients with E-GEJ adenocarcinoma. Pathological complete response (pathCR) and clinical complete response (clinCR) are favorable prognostic factors. We hypothesized that pathCR is associated with best prognosis. Methods: Patients with E-GEJ adenocarcinoma undergoing trimodality therapy were identified from the prospectively maintained databases at our institution. Multiple statistical methods were used. Results: For 314 esophageal cancer patients, the median follow-up time was 44.0 months (95% CI; 34.2-50.9). 107 of 314 patients died at this analysis. 80 patients (25.5%) had a pathCR. 160 patients (51.0%) had a clinCR prior to surgery but did not have pathCR. The remaining 74 (23.6%) had <pathCR and <clinCR. Median OS were: not achieved in pathCR patients, 82.8 months (95% CI; 63.9, NA) in clinCR patients and 27. 6 months (95% CI; 19.4, NA) <pathCR/<clinCR (p<0.001). The median recurrence-free survival (RFS) were: 79.6 months (95% CI; 37.4, NA) in pathCR patients, 67.4 months (95% CI; 31.8, NA) in clinCR patients and 13.5 months (95% CI; 10.4, 21.4) in <pathCR/<clinCR (p<0.001). In multivariate analysis, no lymph node metastasis (p<0.001), not poorly differentiated adenocarcinoma (p=0.002) and pathCR (p=0.02), and cCR (p<0.001) were independent prognosticators of OS and RFS. Conclusions: pathCR and clinCR are independent prognosticators (pathCR producing the best results) and may be helpful in devising new therapeutic and surveillance strategies.

Complete Response after Chemoradiation in Ampullary Carcinoma: A Case Report

2003 ◽  
Vol 89 (1) ◽  
pp. 82-84 ◽  
Author(s):  
Alessio G Morganti ◽  
Gabriella Macchia ◽  
Lucio Trodella ◽  
Vincenzo Valentini ◽  
Guido Costamagna ◽  
...  
Keyword(s):  
Surgical Resection ◽  
External Beam Radiotherapy ◽  
Locally Advanced ◽  
Complete Response ◽  
Ampulla Of Vater ◽  
Ampullary Carcinoma ◽  
Poorly Differentiated Adenocarcinoma ◽  
Good General Condition ◽  
Poorly Differentiated

Aims and Background The case of a 70-year-old patient with resectable, poorly differentiated adenocarcinoma of the ampulla of Vater is presented. Patient and Methods Due to intraoperative hemorrhagic complications, surgical resection was not feasible. The patient was treated with radiochemotherapy consisting of external beam radiotherapy (50.4 Gy; 1.8 Gy/fraction; 5 fractions/week) plus 5-FU (1000 mg/m2/day, continuous IV infusion, days 2–5, week 1 and 5 of radiotherapy) and mitomycin C (10 mg/m2 IV, day 2, week 1 of radiotherapy). Results At five years’ follow-up the patient was in good general condition, without any signs of disease according to CT scan, endoscopic retrograde cholangiopancreatography and tumor marker determination. Multiple random biopsies performed in the ampullary region were negative for tumor growth. Conclusions In patients with ampullary carcinoma the use of concurrent chemoradiation should be considered, particularly when surgical resection is unfeasible due to medical contraindications or locally advanced disease.

scholarly journals A Case of Collision Tumor of MALT Lymphoma and Poorly Differentiated Adenocarcinoma Diagnosed Incidentally After Appendectomy for a Clinical Presentation of Acute Appendicitis.

2019 ◽  
Vol 1 (2) ◽  
pp. 1-7
Author(s):  
Kara T ◽  
Karabulut YY ◽  
Bozdoğan AR ◽  
Yüksek GE
Keyword(s):  
Acute Appendicitis ◽  
Malt Lymphoma ◽  
Clinical Presentation ◽  
B Cell Lymphoma ◽  
Collision Tumor ◽  
Low Grade ◽  
Mesenteric Lymph Nodes ◽  
Poorly Differentiated Adenocarcinoma ◽  
Poorly Differentiated

This report presents a case of collision tumors of low-grade B-cell lymphoma and poorly differentiated adenocarcinoma in the caceum of a 63-year-old woman. Lymphoma was diagnosed incidentally after appendectomy for a clinical presentation of acute appendicitis. Imaging follow-up demonstrated mesenteric lymphadenopathy and liver lesions, and all surgically resected regional mesenteric lymph nodes and liver biopsy were found to be infiltrated by both mucosa-associated lymphoid tissue (MALT) lymphoma and adenocarcinoma. Systemic chemotherapy was administered for advanced colonic adenocarcinoma with liver metastases. The occurrence of synchronous lymphoma and adenocarcinoma of the colorectal region is rare, and this is a previously unreported case of a patient that was diagnosed during management of acute appendicitis.

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