scholarly journals Role of HERG1 potassium channel in both malignant transformation and disease progression in head and neck carcinomas

2012 ◽  
Vol 25 (8) ◽  
pp. 1069-1078 ◽  
Author(s):  
Sofía T Menéndez ◽  
Juan P Rodrigo ◽  
Saúl Álvarez-Teijeiro ◽  
M Ángeles Villaronga ◽  
Eva Allonca ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Head And Neck ◽  
Disease Progression ◽  
Malignant Transformation ◽  
Head And Neck Carcinomas

800 Role of HERG1 Potassium Channel in Both Malignant Transformation and Disease Progression in Head and Neck Carcinomas

2012 ◽  
Vol 48 ◽  
pp. S191
Author(s):  
S. Alvarez-Teiieiro ◽  
S. Tirados Menendez ◽  
J.P. Rodrigo ◽  
M.A. Villaronga ◽  
E. Allonca ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Head And Neck ◽  
Disease Progression ◽  
Malignant Transformation ◽  
Head And Neck Carcinomas

scholarly journals The Role of Pulmonary Resection in Tumors Metastatic from Head and Neck Carcinomas

2010 ◽  
Vol 40 (7) ◽  
pp. 639-644 ◽  
Author(s):  
H. Daiko ◽  
K. Nagai ◽  
J. Yoshida ◽  
M. Nishimura ◽  
T. Hishida ◽  
...  
Keyword(s):  
Head And Neck ◽  
Pulmonary Resection ◽  
Head And Neck Carcinomas

The role of re-irradiation of secondary and recurrent head and neck carcinomas. Is it a potentially curative treatment? A practical approach

2014 ◽  
Vol 40 (1) ◽  
pp. 178-189 ◽  
Author(s):  
Jon Cacicedo ◽  
Arturo Navarro ◽  
Filippo Alongi ◽  
Alfonso Gómez de Iturriaga ◽  
Olga del Hoyo ◽  
...  
Keyword(s):  
Head And Neck ◽  
Practical Approach ◽  
Curative Treatment ◽  
Head And Neck Carcinomas ◽  
Recurrent Head

Neurofibromatosis Type 1 of the head and neck: dilemmas in management

2001 ◽  
Vol 115 (2) ◽  
pp. 151-154 ◽  
Author(s):  
Fernando Rapado ◽  
Ricard Simo ◽  
Mike Small
Keyword(s):  
Head And Neck ◽  
Malignant Transformation ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Assessment And Monitoring ◽  
Abnormal Bleeding ◽  
Age Range ◽  
Dominant Condition

Neurofibromatosis type 1 (NF 1) or Von Recklinghausen’s disease is an autosomal dominant condition characterized by multiple skin cafe´-au-lait lesions and multiple neurofibromas. In the head and neck neurofibromas have a predilection to arise in th deep planes of the neck. Surgical management is nearly always required for functional or cosmetic reasons or to exclude the possibility of malignant transformation. We present four cases of neurofibroma of the head and neck and illustrate the difficulties inherent in managing this condition, particularly the age range in which it may occur, the risk of malignant transformation, the possibility of abnormal bleeding and the morbidity that may be associated with the surgical resection. The role of magnetic resonance (MR) scan in the assessment and monitoring of these lesions is highlighted. We also report a unique association of a pharyngeal pouch with NF 1 in a young (25-year-old) patient.

scholarly journals The role of matrix extracellular proteins and metalloproteinases in head and neck carcinomas: an updated review

2005 ◽  
Vol 71 (1) ◽  
pp. 81-86 ◽  
Author(s):  
Antonio L.A. Pereira ◽  
Simone S.L. Veras ◽  
Éricka J.D. Silveira ◽  
Flávio R.G. Seabra ◽  
Leão Pereira Pinto ◽  
...  
Keyword(s):  
Head And Neck ◽  
Extracellular Proteins ◽  
Head And Neck Carcinomas

scholarly journals Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Georgia Levidou ◽  
Ioly Kotta-Loizou ◽  
Jason Tasoulas ◽  
Thomas Papadopoulos ◽  
Stamatios Theocharis
Keyword(s):  
Head And Neck ◽  
Clinical Significance ◽  
Biological Role ◽  
Current Evidence ◽  
Biological Processes ◽  
Head And Neck Carcinomas ◽  
Present Information ◽  
And Function ◽  
Hu Antigen R

Background. Hu-antigen R (HuR) is a posttranscriptional regulator of several target mRNAs, implicated in carcinogenesis. This review aims to present the current evidence regarding the biological role and potential clinical significance of HuR in head and neck carcinomas. Methods. The existing literature concerning HuR expression and function in head and neck carcinomas is critically presented and summarised. Results. HuR is expressed in the majority of the examined samples, showing higher cytoplasmic levels in malignant or premalignant cases. Moreover, HuR modulates several genes implicated in biological processes important for malignant transformation, growth, and invasiveness. HuR seems to be an adverse prognosticator in patients with OSCCs, whereas a correlation with a more aggressive phenotype is reported in several types of carcinomas. Conclusions. A consistent role of HuR in the carcinogenesis and progression of head and neck carcinomas is suggested; nevertheless, further studies are warranted to expand the present information.

290: Examination of role of ING1 splicing variant (p33ING1) in carcinogenesis and metastasis of head and neck carcinomas

2014 ◽  
Vol 50 ◽  
pp. S68-S69
Author(s):  
E. Gunduz ◽  
O.F. Hatipoglu ◽  
K.O. Yaykasli ◽  
K. Erdogan ◽  
E.N. Cetin ◽  
...  
Keyword(s):  
Head And Neck ◽  
Splicing Variant ◽  
Head And Neck Carcinomas

scholarly journals Can Bioelectrical Impedance Analysis and BMI Be a Prognostic Tool in Head and Neck Cancer Patients? A Review of the Evidence

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 557 ◽  
Author(s):  
Maria Mantzorou ◽  
Maria Tolia ◽  
Antigoni Poultsidi ◽  
Eleni Pavlidou ◽  
Sousana K. Papadopoulou ◽  
...  
Keyword(s):  
Weight Loss ◽  
Head And Neck Cancer ◽  
Electrical Properties ◽  
Nutritional Status ◽  
Head And Neck ◽  
Disease Progression ◽  
Neck Cancer ◽  
Prognostic Role ◽  
The Impact

Background: Malnutrition can significantly affect disease progression and patient survival. The efficiency of weight loss and bioimpedance analysis (BIA)-derived measures in the evaluation of malnutrition, and disease progression and prognosis in patients with head and neck cancer (HNC) are an important area of research. Method: The PubMed database was thoroughly searched, using relative keywords in order to identify clinical trials that investigated the role of BIA-derived measures and weight loss on the disease progression and prognosis of patients with HNC. Twenty-seven studies met the criteria. More specifically, six studies examined the prognostic role of the tissue electrical properties in HNC patients; five examined the role of the tissue electrical properties on identifying malnutrition; four studies looked at the changes in the tissue electrical properties of HNC patients; and 12 examined the prognostic role of weight loss on survival and/or treatment outcomes. Results: Several studies have investigated the role of nutritional status tools on prognosis in HNC patients. Current studies investigating the potential of BIA-derived raw data have shown that phase angle (PA) and capacitance of the cell membrane may be considered prognostic factors of survival. Weight loss may be a prognostic factor for treatment toxicity and survival, despite some conflicting evidence. Conclusions: Further studies are recommended to clarify the role of BIA-derived measures on patients’ nutritional status and the impact of PA on clinical outcomes as well as the prognostic role of weight loss.

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