High pulse pressure is not associated with abnormal activation of the renin–angiotensin–aldosterone system in repaired aortic coarctation

2014 ◽  
Vol 29 (4) ◽  
pp. 268-273 ◽  
Author(s):  
T A L Pedersen ◽  
E B Pedersen ◽  
K Munk ◽  
V E Hjortdal ◽  
K Emmertsen ◽  
...  
Keyword(s):  
Pulse Pressure ◽  
Aortic Coarctation ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
High Pulse Pressure ◽  
High Pulse

Increases in pulse pressure impair acetylcholine-induced vascular relaxation

1995 ◽  
Vol 268 (1) ◽  
pp. H359-H363 ◽  
Author(s):  
S. M. Ryan ◽  
B. J. Waack ◽  
B. L. Weno ◽  
D. D. Heistad
Keyword(s):  
Pulse Pressure ◽  
Carotid Arteries ◽  
Inhibitory Effect ◽  
Isometric Tension ◽  
High Pulse Pressure ◽  
Donor Artery ◽  
Mean Pressure ◽  
High Pulse ◽  
Endothelium Derived Relaxing Factor ◽  
Endothelium Dependent Relaxation

Effects of pulse pressure on acetylcholine-induced endothelium-dependent relaxation were investigated using a cascade bioassay model. Intact carotid arteries from rabbits were perfused at constant flow, and activity of endothelium-derived relaxing factor (EDRF) was assayed by measuring changes in isometric tension in a detector ring without endothelium. When pulse pressure of the donor artery was raised from approximately 2 to 10 mmHg, relaxation to acetylcholine (10(-7) M) was reduced from 31 +/- 3 (means +/- SE) to 20 +/- 2% (expressed as percent relaxation of phenylephrine-induced tone). Responses of the detector ring to nitroprusside were unchanged. Superoxide dismutase (SOD) and indomethacin each prevented impairment of relaxation to acetylcholine at high pulse pressure. When the donor artery was perfused at a higher mean pressure, elevation of pulse pressure also impaired relaxation to acetylcholine, and this impairment was prevented by SOD. These findings suggest that elevation of pulse pressure inhibits acetylcholine-induced, endothelium-dependent relaxation, and this inhibitory effect is mediated by generation of oxygen radicals.

Higher pulse pressure and risk for cardiovascular events in patients with essential hypertension: The Campania Salute Network

2017 ◽  
Vol 25 (3) ◽  
pp. 235-243 ◽  
Author(s):  
Costantino Mancusi ◽  
Maria A Losi ◽  
Raffaele Izzo ◽  
Grazia Canciello ◽  
Maria V Carlino ◽  
...  
Keyword(s):  
Pulse Pressure ◽  
Cardiovascular Events ◽  
Ventricular Hypertrophy ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Major Cardiovascular Events ◽  
High Pulse Pressure ◽  
High Pulse

Background Increased pulse pressure is associated with structural target organ damage, especially in elderly patients, increasing cardiovascular risk. Design In this analysis, we investigated whether high pulse pressure retains a prognostic effect also when common markers of target organ damage are taken into account. Methods We analysed an unselected cohort of treated hypertensive patients from the Campania Salute Network registry ( n = 7336). Participants with available cardiac and carotid ultrasound were required to be free of prevalent cardiovascular disease, with ejection fraction ≥50%, and no more than stage III Chronic Kidney Disease. The median follow-up was 41 months and end-point was occurrence of major cardiovascular events (i.e. fatal and non-fatal stroke or myocardial infarction and sudden death). Based on current guidelines, pulse pressure ≥60 mm Hg was classified as high pulse pressure ( n = 2356), at the time of the initial visit, whereas pulse pressure <60 mm Hg was considered normal ( n = 4980). Results High pulse pressure patients were older, more likely to be women and diabetic, while receiving more antihypertensive medications than normal pulse pressure (all p < 0.0001). High pulse pressure exhibited greater prevalence of left ventricular hypertrophy, and carotid plaque than normal pulse pressure (all p < 0.0001). In Cox regression, high pulse pressure patients had 57% increased hazard of major cardiovascular events, compared to normal pulse pressure (hazard ratio = 1.57; 95% confidence interval: 1.12–2.22, p = 0.01), an effect that was independent of significant prognostic impact of older age, male sex, diabetes, left ventricular hypertrophy, carotid plaque and less prescription of anti-renin–angiotensin system therapy. Conclusions High pulse pressure is a functional marker of target organ damage, predicting cardiovascular events in hypertensive patients, even independently of well-known structural markers of target organ damage.

scholarly journals High Pulse Pressure

2019 ◽  
Vol 74 (15) ◽  
pp. 2012
Author(s):  
Brahim Harbaoui ◽  
Pierre-Yves Courand ◽  
Pierre Lantelme
Keyword(s):  
Pulse Pressure ◽  
High Pulse Pressure ◽  
High Pulse

scholarly journals High Pulse Pressure Associated With Cardiovascular Events in Patients With Type 2 Diabetes Undergoing Hemodialysis

2005 ◽  
Vol 18 (11) ◽  
pp. 1457-1462 ◽  
Author(s):  
L FOUCAN ◽  
J DELOUMEAUX ◽  
K HUE ◽  
T FOUCAN ◽  
A BLANCHETDEVERLY ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Pulse Pressure ◽  
Cardiovascular Events ◽  
High Pulse Pressure ◽  
High Pulse

HIGH PULSE PRESSURE IN A NORMOTENSIVE SUBJECTS IS A PREDICTOR OF SUBSEQUENT HYPERTENSION IN A SCREENED COHORT IN OKINAWA JAPAN

2004 ◽  
Vol 22 (Suppl. 1) ◽  
pp. S102
Author(s):  
Taku Inoue ◽  
K Nagahama ◽  
T Touma ◽  
Y Ohya ◽  
K Iseki ◽  
...  
Keyword(s):  
Pulse Pressure ◽  
High Pulse Pressure ◽  
High Pulse ◽  
Normotensive Subjects

AGE AND ECHOCARDIOGRAPHIC CORRELATES OF HIGH PULSE PRESSURE

2004 ◽  
Vol 22 (Suppl. 1) ◽  
pp. S24
Author(s):  
Jose Alfie ◽  
Giuseppe Schillaci ◽  
Matteo Pirro ◽  
Carlo Porcellati ◽  
Elmo Mannarino
Keyword(s):  
Pulse Pressure ◽  
High Pulse Pressure ◽  
High Pulse

scholarly journals Is High Pulse Pressure a Marker of Preclinical Cardiovascular Disease?

Hypertension ◽  
2005 ◽  
Vol 45 (4) ◽  
pp. 575-579 ◽  
Author(s):  
Giovanni de Simone ◽  
Mary J. Roman ◽  
Michael H. Alderman ◽  
Maurizio Galderisi ◽  
Oreste de Divitiis ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Pulse Pressure ◽  
High Pulse Pressure ◽  
High Pulse
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