scholarly journals High Pulse Pressure Associated With Cardiovascular Events in Patients With Type 2 Diabetes Undergoing Hemodialysis

2005 ◽  
Vol 18 (11) ◽  
pp. 1457-1462 ◽  
Author(s):  
L FOUCAN ◽  
J DELOUMEAUX ◽  
K HUE ◽  
T FOUCAN ◽  
A BLANCHETDEVERLY ◽  
...  
2016 ◽  
Vol 220 ◽  
pp. 467-471 ◽  
Author(s):  
Lu Zhang ◽  
Bingyuan Wang ◽  
Chongjian Wang ◽  
Linlin Li ◽  
Yongcheng Ren ◽  
...  

2017 ◽  
Vol 25 (3) ◽  
pp. 235-243 ◽  
Author(s):  
Costantino Mancusi ◽  
Maria A Losi ◽  
Raffaele Izzo ◽  
Grazia Canciello ◽  
Maria V Carlino ◽  
...  

Background Increased pulse pressure is associated with structural target organ damage, especially in elderly patients, increasing cardiovascular risk. Design In this analysis, we investigated whether high pulse pressure retains a prognostic effect also when common markers of target organ damage are taken into account. Methods We analysed an unselected cohort of treated hypertensive patients from the Campania Salute Network registry ( n = 7336). Participants with available cardiac and carotid ultrasound were required to be free of prevalent cardiovascular disease, with ejection fraction ≥50%, and no more than stage III Chronic Kidney Disease. The median follow-up was 41 months and end-point was occurrence of major cardiovascular events (i.e. fatal and non-fatal stroke or myocardial infarction and sudden death). Based on current guidelines, pulse pressure ≥60 mm Hg was classified as high pulse pressure ( n = 2356), at the time of the initial visit, whereas pulse pressure <60 mm Hg was considered normal ( n = 4980). Results High pulse pressure patients were older, more likely to be women and diabetic, while receiving more antihypertensive medications than normal pulse pressure (all p < 0.0001). High pulse pressure exhibited greater prevalence of left ventricular hypertrophy, and carotid plaque than normal pulse pressure (all p < 0.0001). In Cox regression, high pulse pressure patients had 57% increased hazard of major cardiovascular events, compared to normal pulse pressure (hazard ratio = 1.57; 95% confidence interval: 1.12–2.22, p = 0.01), an effect that was independent of significant prognostic impact of older age, male sex, diabetes, left ventricular hypertrophy, carotid plaque and less prescription of anti-renin–angiotensin system therapy. Conclusions High pulse pressure is a functional marker of target organ damage, predicting cardiovascular events in hypertensive patients, even independently of well-known structural markers of target organ damage.


2008 ◽  
Vol 17 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Anne‐Isabelle Tropeano ◽  
Sandrine Katsahian ◽  
Daniel Molle ◽  
André Grimaldi ◽  
Stéphane Laurent

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1085-P ◽  
Author(s):  
IRENE HRAMIAK ◽  
CYRUS DESOUZA ◽  
JOCHEN SEUFERT ◽  
THOMAS HANSEN ◽  
DESIREE THIELKE ◽  
...  

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