scholarly journals Analysis of PET Neurofunctional Mapping Studies

1995 ◽  
Vol 15 (3) ◽  
pp. 492-504 ◽  
Author(s):  
John R. Votaw ◽  
Hengli H. Li
Keyword(s):  
Positron Emission Tomography ◽  
Region Of Interest ◽  
Functional Mapping ◽  
Emission Tomography ◽  
Data Sets ◽  
Statistical Uncertainty ◽  
Positron Emission

In this work, we present a method for analyzing positron emission tomography (PET) functional mapping experiments. The method is useful for identifying statistically significant differences between two PET data sets. First, uniform-variance Z-images are created and then the statistical uncertainty in region-of-interest values are calculated using a previously published method. The Z-images are calculated from the emission sinograms only

Tracer kinetic model of regional pulmonary function using positron emission tomography

2002 ◽  
Vol 93 (3) ◽  
pp. 1104-1114 ◽  
Author(s):  
Gaetano G. Galletti ◽  
José G. Venegas
Keyword(s):  
Positron Emission Tomography ◽  
Pulmonary Function ◽  
Goodness Of Fit ◽  
Molecular Nitrogen ◽  
Region Of Interest ◽  
Emission Tomography ◽  
Gas Content ◽  
Pulmonary Vasculature ◽  
Model Parameters ◽  
Positron Emission

To determine the spatial distributions of pulmonary perfusion, shunt, and ventilation, we developed a compartmental model of regional 13N-labeled molecular nitrogen (13NN) kinetics measured from positron emission tomography (PET) images. The model features a compartment for right heart and pulmonary vasculature and two compartments for each region of interest: 1) aerated alveolar units and 2) alveolar units with no gas content (shunting). The model was tested on PET data from normal animals (dogs and sheep) and from animals with experimentally injured lungs simulating acute respiratory distress syndrome. The analysis yielded estimates of regional perfusion, shunt fraction, and specific ventilation with excellent goodness-of-fit to the data ( R 2 > 0.99). Model parameters were estimated to within 10% accuracy in the presence of exaggerated levels of experimental noise by using a Monte Carlo sensitivity analysis. Main advantages of the present model are that 1) it separates intraregional blood flow to aerated alveolar units from that shunting across nonaerated units and 2) it accounts and corrects for intraregional tracer removal by shunting blood when estimating ventilation from subsequent washout of tracer. The model was thus found to provide estimates of regional parameters of pulmonary function in sizes of lung regions that could potentially approach the intrinsic resolution for PET images of 13NN in lung (∼7.0 mm for a multiring PET camera).

Improved Image Interpretation with Registered Thoracic CT and Positron Emission Tomography Data Sets

2002 ◽  
Vol 178 (4) ◽  
pp. 939-944 ◽  
Author(s):  
Suzanne L. Aquino ◽  
Jane C. Asmuth ◽  
Richard H. Moore ◽  
Steven B. Weise ◽  
Alan J. Fischman
Keyword(s):  
Positron Emission Tomography ◽  
Image Interpretation ◽  
Emission Tomography ◽  
Data Sets ◽  
Positron Emission Tomography Data ◽  
Thoracic Ct ◽  
Positron Emission ◽  
Tomography Data

scholarly journals Anatomical-Functional Correlation Using an Adjustable MRI-Based Region of Interest Atlas with Positron Emission Tomography

1988 ◽  
Vol 8 (4) ◽  
pp. 513-530 ◽  
Author(s):  
A. C. Evans ◽  
C. Beil ◽  
S. Marrett ◽  
C. J. Thompson ◽  
A. Hakim
Keyword(s):  
Positron Emission Tomography ◽  
Region Of Interest ◽  
Brain Structures ◽  
Regions Of Interest ◽  
Emission Tomography ◽  
Utilization Rate ◽  
Positron Emission ◽  
Reproducible Analysis ◽  
Magnetic Resonance Imaging Mri ◽  
Trained Observers

A procedure is described for combining anatomical information from magnetic resonance imaging (MRI) or computerized tomography (CT) and functional information from positron emission tomography (PET) in a rapid fashion. MRI data are combined with a procedure for the definition, storage, and recall of anatomically based regions of interest. An atlas of standard regions of interest, defined for a set of 18 parallel planes spaced at 6-mm intervals, provides an initial region of interest template for each patient slice. Global adjustments to scale, orientation, and position are applied to obtain an initial match. Individual regions of interest may then be moved, deleted, or redrawn as needed. The ability to store region of interest templates ensures reproducibility of analysis over long periods and introduces a standardization of analysis technique. In 25 brain structures, the mean coefficient of variation in cerebral glucose utilization rate (CMRGlc) measurements among five neuroanatomically trained observers was reduced from 8.1% for manual region of interest definition to 4.0% using the template approach with MRI. Template analysis for space-occupying lesions such as tumors or infarcts is illustrated with PET data from a stroke study, emphasizing the facility for rapid, reproducible analysis of multifunctional studies. MRI-PET matching for a structurally intact caudate nucleus having reduced CMRGlc in Huntington's disease emphasizes the accuracy of anatomical localization required to quantify small structures.

scholarly journals Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum

2003 ◽  
Vol 23 (3) ◽  
pp. 285-300 ◽  
Author(s):  
Diana Martinez ◽  
Mark Slifstein ◽  
Allegra Broft ◽  
Osama Mawlawi ◽  
Dah-Ren Hwang ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Regional Differences ◽  
Dopamine Release ◽  
Region Of Interest ◽  
Volume Effect ◽  
Emission Tomography ◽  
Constant Infusion ◽  
Positron Emission ◽  
Amphetamine Administration ◽  
Striatal Function

The human striatum is functionally organized into limbic, associative, and sensorimotor subdivisions, which process information related to emotional, cognitive, and motor function. Dopamine projections ascending from the midbrain provide important modulatory input to these striatal subregions. The aim of this study was to compare activation of dopamine D2 receptors after amphetamine administration in the functional subdivisions of the human striatum. D2 receptor availability (V3″) was measured with positron emission tomography and [11C]raclopride in 14 healthy volunteers under control conditions and after the intravenous administration of amphetamine (0.3 mg/kg). For each condition, [11C]raclopride was administered as a priming bolus followed by constant infusion, and measurements of D2 receptor availability were obtained under sustained binding equilibrium conditions. Amphetamine induced a significantly larger reduction in D2 receptor availability (ΔV3″) in limbic (ventral striatum, −15.3 ± 11.8%) and sensorimotor (postcommissural putamen, −16.1 ± 9.6%) regions compared with associative regions (caudate and precommissural putamen, −8.1 ± 7.2%). Results of this region-of-interest analysis were confirmed by a voxel-based analysis. Correction for the partial volume effect showed even greater differences in ΔV3″ between limbic (−17.8 ± 13.8%), sensorimotor (−16.6 ± 9.9%), and associative regions (−7.5 ± 7.5%). The increase in euphoria reported by subjects after amphetamine was associated with larger ΔV3″ in the limbic and sensorimotor regions, but not in the associative regions. These results show significant differences in the dopamine response to amphetamine between the functional subdivisions of the human striatum. The mechanisms potentially accounting for these regional differences in amphetamine-induced dopamine release within the striatum remain to be elucidated, but may be related to the asymmetrical feed-forward influences mediating the integration of limbic, cognitive, and sensorimotor striatal function via dopamine cell territories in the ventral midbrain.

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