Motion tracking of low‐activity fiducial markers using adaptive region of interest with list‐mode positron emission tomography

2020 ◽  
Vol 47 (8) ◽  
pp. 3402-3414 ◽  
Author(s):  
Marc J. P. Chamberland ◽  
Robert A. deKemp ◽  
Tong Xu
Keyword(s):  
Positron Emission Tomography ◽  
Motion Tracking ◽  
Region Of Interest ◽  
Emission Tomography ◽  
Fiducial Markers ◽  
List Mode ◽  
Positron Emission ◽  
Low Activity

scholarly journals Subsecond total-body imaging using ultrasensitive positron emission tomography

2020 ◽  
Vol 117 (5) ◽  
pp. 2265-2267 ◽  
Author(s):  
Xuezhu Zhang ◽  
Simon R. Cherry ◽  
Zhaoheng Xie ◽  
Hongcheng Shi ◽  
Ramsey D. Badawi ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Motion Tracking ◽  
The Body ◽  
Body Motion ◽  
Emission Tomography ◽  
Ct Scanner ◽  
External Monitoring ◽  
Time Motion ◽  
Positron Emission ◽  
Total Body

A 194-cm-long total-body positron emission tomography/computed tomography (PET/CT) scanner (uEXPLORER), has been constructed to offer a transformative platform for human radiotracer imaging in clinical research and healthcare. Its total-body coverage and exceptional sensitivity provide opportunities for innovative studies of physiology, biochemistry, and pharmacology. The objective of this study is to develop a method to perform ultrahigh (100 ms) temporal resolution dynamic PET imaging by combining advanced dynamic image reconstruction paradigms with the uEXPLORER scanner. We aim to capture the fast dynamics of initial radiotracer distribution, as well as cardiac motion, in the human body. The results show that we can visualize radiotracer transport in the body on timescales of 100 ms and obtain motion-frozen images with superior image quality compared to conventional methods. The proposed method has applications in studying fast tracer dynamics, such as blood flow and the dynamic response to neural modulation, as well as performing real-time motion tracking (e.g., cardiac and respiratory motion, and gross body motion) without any external monitoring device (e.g., electrocardiogram, breathing belt, or optical trackers).

Tracer kinetic model of regional pulmonary function using positron emission tomography

2002 ◽  
Vol 93 (3) ◽  
pp. 1104-1114 ◽  
Author(s):  
Gaetano G. Galletti ◽  
José G. Venegas
Keyword(s):  
Positron Emission Tomography ◽  
Pulmonary Function ◽  
Goodness Of Fit ◽  
Molecular Nitrogen ◽  
Region Of Interest ◽  
Emission Tomography ◽  
Gas Content ◽  
Pulmonary Vasculature ◽  
Model Parameters ◽  
Positron Emission

To determine the spatial distributions of pulmonary perfusion, shunt, and ventilation, we developed a compartmental model of regional 13N-labeled molecular nitrogen (13NN) kinetics measured from positron emission tomography (PET) images. The model features a compartment for right heart and pulmonary vasculature and two compartments for each region of interest: 1) aerated alveolar units and 2) alveolar units with no gas content (shunting). The model was tested on PET data from normal animals (dogs and sheep) and from animals with experimentally injured lungs simulating acute respiratory distress syndrome. The analysis yielded estimates of regional perfusion, shunt fraction, and specific ventilation with excellent goodness-of-fit to the data ( R 2 > 0.99). Model parameters were estimated to within 10% accuracy in the presence of exaggerated levels of experimental noise by using a Monte Carlo sensitivity analysis. Main advantages of the present model are that 1) it separates intraregional blood flow to aerated alveolar units from that shunting across nonaerated units and 2) it accounts and corrects for intraregional tracer removal by shunting blood when estimating ventilation from subsequent washout of tracer. The model was thus found to provide estimates of regional parameters of pulmonary function in sizes of lung regions that could potentially approach the intrinsic resolution for PET images of 13NN in lung (∼7.0 mm for a multiring PET camera).

Detection of respiratory tumour motion using intrinsic list mode-driven gating in positron emission tomography

2010 ◽  
Vol 37 (12) ◽  
pp. 2315-2327 ◽  
Author(s):  
Florian Büther ◽  
Iris Ernst ◽  
Mohammad Dawood ◽  
Peter Kraxner ◽  
Michael Schäfers ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
List Mode ◽  
Positron Emission

scholarly journals Tracking and characterizing the head motion of unanaesthetized rats in positron emission tomography

2012 ◽  
Vol 9 (76) ◽  
pp. 3094-3107 ◽  
Author(s):  
Andre Kyme ◽  
Steven Meikle ◽  
Clive Baldock ◽  
Roger Fulton
Keyword(s):  
Positron Emission Tomography ◽  
Motion Tracking ◽  
Emission Tomography ◽  
Head Motion ◽  
Published Data ◽  
Freely Moving Rats ◽  
Positron Emission ◽  
Optical Motion ◽  
Freely Moving

Positron emission tomography (PET) is an important in vivo molecular imaging technique for translational research. Imaging unanaesthetized rats using motion-compensated PET avoids the confounding impact of anaesthetic drugs and enables animals to be imaged during normal or evoked behaviour. However, there is little published data on the nature of rat head motion to inform the design of suitable marker-based motion-tracking set-ups for brain imaging—specifically, set-ups that afford close to uninterrupted tracking. We performed a systematic study of rat head motion parameters for unanaesthetized tube-bound and freely moving rats with a view to designing suitable motion-tracking set-ups in each case. For tube-bound rats, using a single appropriately placed binocular tracker, uninterrupted tracking was possible greater than 95 per cent of the time. For freely moving rats, simulations and measurements of a live subject indicated that two opposed binocular trackers are sufficient (less than 10% interruption to tracking) for a wide variety of behaviour types. We conclude that reliable tracking of head pose can be achieved with marker-based optical-motion-tracking systems for both tube-bound and freely moving rats undergoing PET studies without sedation.

scholarly journals Anatomical-Functional Correlation Using an Adjustable MRI-Based Region of Interest Atlas with Positron Emission Tomography

1988 ◽  
Vol 8 (4) ◽  
pp. 513-530 ◽  
Author(s):  
A. C. Evans ◽  
C. Beil ◽  
S. Marrett ◽  
C. J. Thompson ◽  
A. Hakim
Keyword(s):  
Positron Emission Tomography ◽  
Region Of Interest ◽  
Brain Structures ◽  
Regions Of Interest ◽  
Emission Tomography ◽  
Utilization Rate ◽  
Positron Emission ◽  
Reproducible Analysis ◽  
Magnetic Resonance Imaging Mri ◽  
Trained Observers

A procedure is described for combining anatomical information from magnetic resonance imaging (MRI) or computerized tomography (CT) and functional information from positron emission tomography (PET) in a rapid fashion. MRI data are combined with a procedure for the definition, storage, and recall of anatomically based regions of interest. An atlas of standard regions of interest, defined for a set of 18 parallel planes spaced at 6-mm intervals, provides an initial region of interest template for each patient slice. Global adjustments to scale, orientation, and position are applied to obtain an initial match. Individual regions of interest may then be moved, deleted, or redrawn as needed. The ability to store region of interest templates ensures reproducibility of analysis over long periods and introduces a standardization of analysis technique. In 25 brain structures, the mean coefficient of variation in cerebral glucose utilization rate (CMRGlc) measurements among five neuroanatomically trained observers was reduced from 8.1% for manual region of interest definition to 4.0% using the template approach with MRI. Template analysis for space-occupying lesions such as tumors or infarcts is illustrated with PET data from a stroke study, emphasizing the facility for rapid, reproducible analysis of multifunctional studies. MRI-PET matching for a structurally intact caudate nucleus having reduced CMRGlc in Huntington's disease emphasizes the accuracy of anatomical localization required to quantify small structures.

Markerless Motion Tracking of Awake Animals in Positron Emission Tomography

2014 ◽  
Vol 33 (11) ◽  
pp. 2180-2190 ◽  
Author(s):  
Andre Kyme ◽  
Stephen Se ◽  
Steven Meikle ◽  
Georgios Angelis ◽  
Will Ryder ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Motion Tracking ◽  
Emission Tomography ◽  
Positron Emission
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