scholarly journals Prenatal exposure to lipopolysaccharide alters the intrarenal renin–angiotensin system and renal damage in offspring rats

2009 ◽  
Vol 33 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Xue-Qin Hao ◽  
Hai-Gang Zhang ◽  
Zhi-Bing Yuan ◽  
Dan-Li Yang ◽  
Li-Yun Hao ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Renal Damage ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Prenatal Exposure to Inflammation Induced by Zymosan Results in Activation of Intrarenal Renin-Angiotensin System in Adult Offspring Rats

Inflammation ◽  
2010 ◽  
Vol 33 (6) ◽  
pp. 408-414 ◽  
Author(s):  
Xue-Qin Hao ◽  
Hai-Gang Zhang ◽  
Shu-Hui Li ◽  
Yi Jia ◽  
Ya Liu ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Renin Angiotensin System ◽  
Adult Offspring ◽  
Angiotensin System ◽  
Renin Angiotensin

Disturbed circadian rhythm of the intrarenal renin-angiotensin system: relevant to nocturnal hypertension and renal damage

2014 ◽  
Vol 19 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Shinsuke Isobe ◽  
Naro Ohashi ◽  
Tomoyuki Fujikura ◽  
Takayuki Tsuji ◽  
Yukitoshi Sakao ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Renal Damage ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Nocturnal Hypertension

scholarly journals High Fructose‐Induced Hypertension and Renal Damage Are Exaggerated in Dahl Salt‐Sensitive Rats via Renal Renin‐Angiotensin System Activation

2021 ◽  
Author(s):  
Lusi Xu ◽  
Gaizun Hu ◽  
Jiahe Qiu ◽  
Yuxuan Fan ◽  
Yixuan Ma ◽  
...  
Keyword(s):  
Renal Damage ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
High Fructose ◽  
Induced Hypertension ◽  
System Activation ◽  
Renal Expression

Background High‐fructose diet (HFr) induces hypertension and renal damage. However, it has been unknown whether the HFr‐induced hypertension and renal damage are exaggerated in subjects with salt sensitivity. We tested impacts of HFr in Dahl salt‐sensitive (DS) and salt‐resistant (DR) rats. Methods and Results Male DS and DR rats were fed control diet or HFr (60% fructose) with normal‐salt content. After 12 weeks, plasma and urinary parameters, renal histological characteristics, and renal expression of renin‐angiotensin system components were examined. Furthermore, effects of renin‐angiotensin system inhibitors were also examined in DS rats fed the HFr. HFr elevated blood pressure in DS rats but not in DR rats. HFr increased urinary albumin and liver type fatty acid binding protein excretions in both rats, but the excretions were exaggerated in DS rats. HFr increased plasma lipids and uric acid in both rats, whereas HFr increased creatinine clearance in DS rats but not DR rats. Although HFr decreased plasma renin activity in DS rats, HFr‐induced glomerular injury, afferent arteriolar thickening, and renal interstitial fibrosis were exaggerated in DS rats. HFr increased renal expression of angiotensinogen, renin, (pro)renin receptor, angiotensin‐converting enzyme, and angiotensin II type 1 receptor in DS rat, whereas HFr increased only angiotensin‐converting enzyme expression and decreased renin and angiotensin II type 1 receptor expressions in DR rats. Enalapril and candesartan attenuated the HFr‐induced hypertension, albuminuria, glomerular hyperfiltration, and renal damage in DS rats. Conclusion HFr‐induced hypertension and renal damage are exaggerated in DS rats via renal renin‐angiotensin system activation, which can be controlled by renin‐angiotensin system inhibitors.

scholarly journals Prenatal exposure to interleukin-6 results in hypertension and alterations in the renin-angiotensin system of the rat

2006 ◽  
Vol 575 (3) ◽  
pp. 855-867 ◽  
Author(s):  
Anne-Maj Samuelsson ◽  
Camilla Alexanderson ◽  
Johan Mölne ◽  
Börje Haraldsson ◽  
Peter Hansell ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Interleukin 6 ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin
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