scholarly journals Serum Uric Acid Levels and Renal Damage in Hyperuricemic Hypertensive Patients Treated With Renin-Angiotensin System Blockers

2010 ◽  
Vol 23 (6) ◽  
pp. 675-680 ◽  
Author(s):  
A. Berni ◽  
M. Boddi ◽  
E. B. Fattori ◽  
I. Cecioni ◽  
S. Berardino ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Renal Damage ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Hypertensive Patients ◽  
Renin Angiotensin ◽  
Renin Angiotensin System Blockers

Hyperuricemia Inhibition Protects SD Rats Against Fructose-Induced Obesity Hypertension Via Modulation of Inflammation and Renin-Angiotensin System in Adipose Tissue

2019 ◽  
Author(s):  
Jun Xia Zhang ◽  
Xue Lin ◽  
Jinxiu Xu ◽  
Feng Tang
Keyword(s):  
Adipose Tissue ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Inflammatory Responses ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
High Fructose ◽  
Obesity Hypertension ◽  
Adipose Inflammation

Abstract Objective The present study was aimed to reveal the relationship between uric acid and fructose-induced obesity hypertension and its mechanisms. Methods A rat model with obesity hypertension was induced by a high-fructose diet. In the experiment I, the rats were fed with fructose for 8 wks along with allopurinol or benzbromarone at the beginning. In the experiment II, the rats were fed with fructose for 8 wks firstly. And then, these rats were treated with allopurinol or benzbromarone for additional 6 wks. Results Fructose-fed rats showed hyperuricemia, abdominal obesity hypertension and an activation in adipose renin-angiotensin system (RAS). Also, fructose-fed rats had higher levels of proinflammatory cytokines and more macrophages infiltrating in adipose tissue. In the experiment I, allopurinol and benzbromarone significantly reduced serum uric acid at 8 wk. Adipose RAS overactivation, adipose inflammatory responses and the development of obesity hypertension were all effectively prevented by hyperuricemia inhibition. In the experiment II, 6-wk treatment with allopurinol and benzbromarone significantly decreased serum uric acid, downregulated adipose RAS, abolished adipose inflammation and improved obesity hypertension. Conclusion In conclusion, urate-lowering therapy protects rats against fructose-induced obesity hypertension. The mechanisms appear to be via downregulated adipose RAS and reduced inflammation in adipose tissue.

Serum Uric Acid and the Renin-Angiotensin System in Hypertension

1978 ◽  
Vol 26 (6) ◽  
pp. 241-247 ◽  
Author(s):  
I. Saito ◽  
T. Saruta ◽  
K. Kondo ◽  
R. Nakamura ◽  
T. Oguro ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Relation Between Renin-Angiotensin System Blockers and Survival Following Isolated Aortic Valve Replacement for Aortic Stenosis

2018 ◽  
Vol 121 (4) ◽  
pp. 455-460 ◽  
Author(s):  
Julien Magne ◽  
Barthélémy Guinot ◽  
Alexandre Le Guyader ◽  
Emmanuelle Bégot ◽  
Jean-Philippe Marsaud ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Stenosis ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Renin Angiotensin System Blockers

scholarly journals Acute effects of renin-angiotensin system blockade on arterial function in hypertensive patients

2007 ◽  
Vol 21 (8) ◽  
pp. 654-663 ◽  
Author(s):  
K A Aznaouridis ◽  
K S Stamatelopoulos ◽  
E N Karatzis ◽  
A D Protogerou ◽  
C M Papamichael ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
Acute Effects ◽  
Arterial Function ◽  
Angiotensin System ◽  
Hypertensive Patients ◽  
Renin Angiotensin
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