scholarly journals Prenatal exposure to interleukin-6 results in hypertension and alterations in the renin-angiotensin system of the rat

2006 ◽  
Vol 575 (3) ◽  
pp. 855-867 ◽  
Author(s):  
Anne-Maj Samuelsson ◽  
Camilla Alexanderson ◽  
Johan Mölne ◽  
Börje Haraldsson ◽  
Peter Hansell ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Interleukin 6 ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Prenatal exposure to lipopolysaccharide alters the intrarenal renin–angiotensin system and renal damage in offspring rats

2009 ◽  
Vol 33 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Xue-Qin Hao ◽  
Hai-Gang Zhang ◽  
Zhi-Bing Yuan ◽  
Dan-Li Yang ◽  
Li-Yun Hao ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Renal Damage ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Prenatal Exposure to Inflammation Induced by Zymosan Results in Activation of Intrarenal Renin-Angiotensin System in Adult Offspring Rats

Inflammation ◽  
2010 ◽  
Vol 33 (6) ◽  
pp. 408-414 ◽  
Author(s):  
Xue-Qin Hao ◽  
Hai-Gang Zhang ◽  
Shu-Hui Li ◽  
Yi Jia ◽  
Ya Liu ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Renin Angiotensin System ◽  
Adult Offspring ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Inflammation and Hypertension: The Interplay of Interleukin-6, Dietary Sodium, and the Renin-Angiotensin System in Humans

2011 ◽  
Vol 24 (10) ◽  
pp. 1143-1148 ◽  
Author(s):  
B. Chamarthi ◽  
G. H. Williams ◽  
V. Ricchiuti ◽  
N. Srikumar ◽  
P. N. Hopkins ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Renin Angiotensin System ◽  
Dietary Sodium ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals COVID-19: age, Interleukin-6, C-Reactive Protein and lymphocytes as key clues from a multicentre retrospective study in Spain

2020 ◽  
Author(s):  
Aurora Jurado ◽  
María C. Martín ◽  
Cristina Abad-Molina ◽  
Antonio Orduña ◽  
Alba Martínez ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Interleukin 6 ◽  
Clinical Laboratory ◽  
Case Fatality ◽  
Renin Angiotensin System ◽  
Local Health ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Age Related ◽  
Renin Angiotensin System Blockers

ABSTRACTBackgroundSARS-CoV-2 infection has widely spread to the hugest public health challenge to date, COVID-19 pandemic. Different fatality rates among countries are probably due to non-standardized records being carried out by local health authorities. Spanish case-fatality rate is 11.94%, far higher to those reported in Asia or by other European countries. A multicenter retrospective study was performed of demographic, clinical, laboratory and immunological features of 574 Spanish COVID-19 hospitalized patients and their outcomes. The use of use of renin-angiotensin system blockers was also analyzed as a risk factor.ResultsIn this study, 27.7% of cases presented a mild curse, 42% a moderate one and for 30.3% of cases, the course was severe. Ages ranged from 18 to 98 (average 63.2). Fifty eight percent (58.9%) of patients were male. Interleukin 6 was higher as severity increased. On the other hand, CD8 lymphocyte count was significantly lower as severity grew and subpopulations CD4, CD8, CD19 and NK showed concordant lowering trends. Severity-related natural killer percent descents were evidenced just within aged cases. A significant severity-related decrease of CD4 lymphocytes was found in males. The use of renin-angiotensin system blockers was associated with moderate or mild disease courses.ConclusionsAge and age-related comorbidities, such as dyslipidaemia, hypertension or diabetes, determined more frequent severe forms of the disease in this study than in previous literature cohorts. Our cases are older than those so far reported and clinical course of the disease is found to be impaired by age. Immunosenescence might be therefore a suitable explanation for immune system effectors severity-related hampering. Adaptive immunity would go exhausted and a huge ineffective and almost deleterious innate response would account for COVID-19 severity. Renin-angiotensin system blockers treatment in hypertensive patients has a protective effect as regarding COVID-19 severity.

Sign in / Sign up

Export Citation Format

Share Document