A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1

Nature ◽  
1994 ◽  
Vol 370 (6490) ◽  
pp. 567-571 ◽  
Author(s):  
Heather Marshall ◽  
Michèle Studer ◽  
Heike Pöpperl ◽  
Sam Aparicio ◽  
Atsushi Kuroiwa ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Homeobox Gene ◽  
Response Element ◽  
Retinoic Acid Response Element ◽  
Early Expression

Cloning and Characterization of the Murine PKC α Promoter: Identification of a Retinoic Acid Response Element

1999 ◽  
Vol 263 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Dinakar S. Desai ◽  
Syu-ichi Hirai ◽  
William E. Karnes ◽  
Richard M. Niles ◽  
Shi-geo Ohno
Keyword(s):  
Retinoic Acid ◽  
Response Element ◽  
Retinoic Acid Response Element

scholarly journals Liganded retinoic acid X receptor α represses connexin 43 through a potential retinoic acid response element in the promoter region

2016 ◽  
Vol 80 (1) ◽  
pp. 159-168 ◽  
Author(s):  
Ruoyi Gu ◽  
Jun Xu ◽  
Yixiang Lin ◽  
Jing Zhang ◽  
Huijun Wang ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Promoter Region ◽  
Connexin 43 ◽  
Response Element ◽  
Retinoic Acid Response Element

scholarly journals Cytochrome P450RAI(CYP26) Promoter: A Distinct Composite Retinoic Acid Response Element Underlies the Complex Regulation of Retinoic Acid Metabolism

2000 ◽  
Vol 14 (9) ◽  
pp. 1483-1497 ◽  
Author(s):  
Olivier Loudig ◽  
Charolyn Babichuk ◽  
Jay White ◽  
Suzan Abu-Abed ◽  
Chris Mueller ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acid Metabolism ◽  
Response Element ◽  
Retinoic Acid Response Element ◽  
Complex Regulation

scholarly journals Activation of the phosphoenolpyruvate carboxykinase gene retinoic acid response element is dependent on a retinoic acid receptor/coregulator complex.

1992 ◽  
Vol 12 (12) ◽  
pp. 5527-5535 ◽  
Author(s):  
R K Hall ◽  
D K Scott ◽  
E L Noisin ◽  
P C Lucas ◽  
D K Granner
Keyword(s):  
Retinoic Acid ◽  
Transcriptional Control ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Mutational Analysis ◽  
Retinoic Acid Receptor ◽  
Retinoid Receptor ◽  
Response Element ◽  
Acid Receptor ◽  
Receptor Alpha ◽  
Retinoic Acid Response Element

The accessory factor 1 (AF1) element is an upstream transcriptional control region that plays a role in the response of the phosphoenolpyruvate carboxykinase (PEPCK) gene to both glucocorticoids and retinoic acid. We demonstrate here that retinoic acid receptor alpha (RAR alpha) binds to a sequence within the AF1 element, TGACCT (site B), that is a consensus retinoic acid response element (RARE) half-site. A similar DNA sequence, TGGCCG (site C), located 1 bp downstream of site B, is not involved in the binding of RAR alpha monomers or dimers but is required for the constitution of a functional RARE. Site C is also required for the formation of a complex involving RAR alpha and a liver nuclear factor designated CR, for coregulator. Mutational analysis of the AF1 element shows that the RAR alpha/CR complex is the trans-acting unit that mediates the retinoic acid response of the PEPCK gene. Another member of the retinoid receptor family, retinoid X receptor alpha (RXR alpha), can also form a complex with RAR alpha and the AF1 element. Several observations, including the observation that RXR alpha antibody interacts with CR, indicate that RXR alpha and CR are identical or closely related proteins. Through RXR alpha forms a complex with RAR alpha and the AF1 element, we demonstrate that the AF1 element is functionally distinguishable from a retinoid X response element. Taken together, our results show that the AF1 element contains an RARE that mediates a retinoic acid response by binding an RAR alpha/coregulator complex; this coregulator is presumably RXR alpha.

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