A tri-platinum complex containing a coordinatively naked platinum atom

Nature ◽  
1990 ◽  
Vol 344 (6266) ◽  
pp. 526-528 ◽  
Author(s):  
T. Tanase ◽  
Y. Kudo ◽  
M. Ohno ◽  
K. Kobayashi ◽  
Y. Yamamoto
2001 ◽  
Vol 79 (2) ◽  
pp. 196-200 ◽  
Author(s):  
C Le Sech ◽  
K Takakura ◽  
C Saint-Marc ◽  
H Frohlich ◽  
M Charlier ◽  
...  

We determined The number of single and double strand breaks (ssb and dsb) in a DNA-chloroterpyridine platinum complex induced by resonant photoabsorption in the LIII innershell of a platinum atom. The number of ssb and dsb were measured in supercoiled plasmids (AG30) versus the chloroterpyridine platinum concentration, i.e., the ratio of intercalated molecules to the number of phosphate sites in DNA. A significant increase in the number of ssb and dsb was observed when the DNA contained intercalated molecules. This technique is an efficient way to induce ssb and dsb triggered by the atomic Auger effect.Key words: DNA breaks, Auger effect, resonant photoabsorption, intercalated molecules.


2021 ◽  
Vol 52 (S1) ◽  
pp. 637-637
Author(s):  
Jianfeng Guo ◽  
Zhangcheng Liao ◽  
Rongrong Xia ◽  
Hong Lin ◽  
Zixing Wang

1993 ◽  
Vol 12 (1) ◽  
pp. 6-7 ◽  
Author(s):  
J. R. Berenguer ◽  
L. R. Falvello ◽  
J. Fornies ◽  
E. Lalinde ◽  
M. Tomas
Keyword(s):  

2015 ◽  
Vol 44 (8) ◽  
pp. 3544-3556 ◽  
Author(s):  
Nicola Margiotta ◽  
Emanuele Petruzzella ◽  
James A. Platts ◽  
Shaun T. Mutter ◽  
Robert J. Deeth ◽  
...  

The anticancer-active platinum complex with cis-1,4-diaminocyclohexane has proved to be very valuable in detecting multiple conformers in adducts with oligonucleotides.


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