Linguistic characteristics in a non-trauma-related narrative task are associated with PTSD diagnosis and symptom severity.

2015 ◽  
Vol 7 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Santiago Papini ◽  
Patricia Yoon ◽  
Mikael Rubin ◽  
Teresa Lopez-Castro ◽  
Denise A. Hien
2017 ◽  
Vol 205 (2) ◽  
pp. 83-86 ◽  
Author(s):  
Jeanne M.D. Jakob ◽  
Kristen Lamp ◽  
Sheila A.M. Rauch ◽  
Erin R. Smith ◽  
Katherine R. Buchholz

2009 ◽  
Vol 119 (1) ◽  
pp. 25-34 ◽  
Author(s):  
R. Yehuda ◽  
J. Schmeidler ◽  
E. Labinsky ◽  
A. Bell ◽  
A. Morris ◽  
...  

Author(s):  
Heike Weber ◽  
Adam X. Maihofer ◽  
Nenad Jaksic ◽  
Elma Feric Bojic ◽  
Sabina Kucukalic ◽  
...  

Abstract Objectives Posttraumatic stress disorder (PTSD) is triggered by extremely stressful environmental events and characterized by high emotional distress, re-experiencing of trauma, avoidance and hypervigilance. The present study uses polygenic risk scores (PRS) derived from the UK Biobank (UKBB) mega-cohort analysis as part of the PGC PTSD GWAS effort to determine the heritable basis of PTSD in the South Eastern Europe (SEE)-PTSD cohort. We further analyzed the relation between PRS and additional disease-related variables, such as number and intensity of life events, coping, sex and age at war on PTSD and CAPS as outcome variables. Methods Association of PRS, number and intensity of life events, coping, sex and age on PTSD were calculated using logistic regression in a total of 321 subjects with current and remitted PTSD and 337 controls previously subjected to traumatic events but not having PTSD. In addition, PRS and other disease-related variables were tested for association with PTSD symptom severity, measured by the Clinician Administrated PTSD Scale (CAPS) by liner regression. To assess the relationship between the main outcomes PTSD diagnosis and symptom severity, each of the examined variables was adjusted for all other PTSD related variables. Results The categorical analysis showed significant polygenic risk in patients with remitted PTSD and the total sample, whereas no effects were found on symptom severity. Intensity of life events as well as the individual coping style were significantly associated with PTSD diagnosis in both current and remitted cases. The dimensional analyses showed as association of war-related frequency of trauma with symptom severity, whereas the intensity of trauma yielded significant results independently of trauma timing in current PTSD. Conclusions The present PRS application in the SEE-PTSD cohort confirms modest but significant polygenic risk for PTSD diagnosis. Environmental factors, mainly the intensity of traumatic life events and negative coping strategies, yielded associations with PTSD both categorically and dimensionally with more significant p-values. This suggests that, at least in the present cohort of war-related trauma, the association of environmental factors and current individual coping strategies with PTSD psychopathology was stronger than the polygenic risk.


2012 ◽  
Vol 25 (4) ◽  
pp. 368-375 ◽  
Author(s):  
Princess E. Osei-Bonsu ◽  
Avron Spiro ◽  
Mark R. Schultz ◽  
Karen A. Ryabchenko ◽  
Eric Smith ◽  
...  

2020 ◽  
Vol Volume 16 ◽  
pp. 43-54
Author(s):  
Yirui Hu ◽  
Xin Chu ◽  
Thomas G Urosevich ◽  
Stuart N Hoffman ◽  
H Lester Kirchner ◽  
...  

2019 ◽  
Vol 4 (4) ◽  
pp. 607-614
Author(s):  
Jean Abitbol

The purpose of this article is to update the management of the treatment of the female voice at perimenopause and menopause. Voice and hormones—these are 2 words that clash, meet, and harmonize. If we are to solve this inquiry, we shall inevitably have to understand the hormones, their impact, and the scars of time. The endocrine effects on laryngeal structures are numerous: The actions of estrogens and progesterone produce modification of glandular secretions. Low dose of androgens are secreted principally by the adrenal cortex, but they are also secreted by the ovaries. Their effect may increase the low pitch and decease the high pitch of the voice at menopause due to important diminution of estrogens and the privation of progesterone. The menopausal voice syndrome presents clinical signs, which we will describe. I consider menopausal patients to fit into 2 broad types: the “Modigliani” types, rather thin and slender with little adipose tissue, and the “Rubens” types, with a rounded figure with more fat cells. Androgen derivatives are transformed to estrogens in fat cells. Hormonal replacement therapy should be carefully considered in the context of premenopausal symptom severity as alternative medicine. Hippocrates: “Your diet is your first medicine.”


2017 ◽  
Vol 31 (3) ◽  
pp. 326-335 ◽  
Author(s):  
Bryce Hruska ◽  
Maria L. Pacella ◽  
Richard L. George ◽  
Douglas L. Delahanty

2020 ◽  
Vol 67 (6) ◽  
pp. 712-722
Author(s):  
Sebastian Gmeinwieser ◽  
Kai Sebastian Schneider ◽  
Maximilian Bardo ◽  
Timo Brockmeyer ◽  
York Hagmayer

2008 ◽  
Author(s):  
Katherine Stephenson ◽  
David Valentiner ◽  
Holly Orcutt ◽  
Mandy Rabenhorst ◽  
Leslie Matuszewich

2007 ◽  
Author(s):  
Juliet Vogel ◽  
Jessica Levitt ◽  
James Rodriguez ◽  
Jameson Foster ◽  
Marleen Radigan
Keyword(s):  

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