Vascular drug found to improve learning and memory in middle-aged rats: Drug has been well tolerated in humans for years

2009 ◽  
Keyword(s):  
Learning And Memory ◽  
Aged Rats ◽  
Middle Aged

Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats

2017 ◽  
Vol 316 ◽  
pp. 74-81 ◽  
Author(s):  
Rafael M. Bitencourt ◽  
Ana C. Guerra de Souza ◽  
Maíra A. Bicca ◽  
Fabrício A. Pamplona ◽  
Nelson de Mello ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Deficits ◽  
Spatial Learning And Memory ◽  
Aged Rats ◽  
Middle Aged ◽  
B1 Receptors ◽  
Learning And Memory Deficits

scholarly journals Tadalafil modulates intracerebroventricular streptozotocin-induced cognition and memory impairment in the young and middle middle-aged rats

2021 ◽  
Author(s):  
Siamak Shahidi ◽  
Masoumeh Asadbegi ◽  
Nasrin Hashemi-Firouzi ◽  
Alireza Komaki ◽  
Minoo Mahmoodi
Keyword(s):  
Learning And Memory ◽  
Memory Impairment ◽  
Cognitive Learning ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Aged Rats ◽  
Middle Aged ◽  
Male Wistar Rats ◽  
Significant Impairment ◽  
Aged Subjects

Background: Learning and memory may decline due to Alzheimer’s disease (AD) in older adults. A reduction in cyclic guanosine monophosphate concentration and an increase in phosphodiesterase activity have been reported in the process of aging. Although phosphodiesterase (PDE) type 5 inhibitor, Tadalafil is used to treat erectile dysfunction; PDE inhibitors possibly prevent cognition impairment in aging. This study was designed to investigate the effects of tadalafil on memory in middle-aged and young healthy and AD rats. Methods: Memory impairment was induced by intracerebroventricular (ICV) administration of streptozotocin (STZ; 3 mg/kg) in AD rats. Male Wistar rats (middle-aged and young) were distributed into six groups as follows: two control, two AD, and two AD+tadalafil (1 mg/kg) groups. Saline or tadalafil was administered once a day orally for 40 consecutive days. Animals were tested using novel object recognition (NOR), passive avoidance learning (PAL), and Morris water maze (MWM) tests. Results: Aged AD rats exhibited a significant impairment in cognition in the NOR test and impaired learning and memory in PAL and MWM tests compared with the control aged rats. Tadalafil treatment in aged AD rats significantly improved the discrimination index in the NOR test, decreased the time spent in the dark compartment in the PAL test, and increased time spent in the target quadrant in MWM tests compared with aged AD rats. In young AD rats, treatment with tadalafil significantly enhanced cognition, learning, and memory in the NOR, PAL, and MWM tests compared with young AD rats treated with saline. Conclusion: Tadalafil treatment in aged rats improves cognition and memory after STZ-induced (ICV) memory impairment. It can be concluded that chronic treatment with tadalafil is protective against cognitive, learning, and memory impairment in both young and aged subjects.

Protective Effects of Exercise Training Against Aged Induced the Reduction of Cardiac Angiogenic Capacity in Middle Aged Rats

2020 ◽  
Vol 04 (01) ◽  
Author(s):  
Titiporn Mekrungruangwong ◽  
Pimpetch Kasetsuwan ◽  
Sheepsumon Viboolvorakul ◽  
Suthiluk Patumraj
Keyword(s):  
Exercise Training ◽  
Protective Effects ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Tocotrienol improves learning and memory deficit of aged rats

2016 ◽  
Vol 58 (2) ◽  
pp. 114-121 ◽  
Author(s):  
Nozomi Kaneai ◽  
Kazumi Sumitani ◽  
Koji Fukui ◽  
Taisuke Koike ◽  
Hirokatsu Takatsu ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Memory Deficit ◽  
Aged Rats ◽  
Learning And Memory Deficit

scholarly journals Effects of Food Restriction on Mechanical Properties of Arterial System in Adult and Middle-Aged Rats

1999 ◽  
Vol 54 (10) ◽  
pp. B441-B447 ◽  
Author(s):  
K.-C. Chang ◽  
C.-Y. Chow ◽  
Y.-I. Peng ◽  
T.-J. Chen ◽  
Y.-F. Tsai
Keyword(s):  
Mechanical Properties ◽  
Food Restriction ◽  
Arterial System ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Age-Related Effects on Right Femoral Bone of Male Wistar Rats: A Morphometric and Biomechanical Study

2021 ◽  
Author(s):  
Sheila Martins Puelker ◽  
Sonia Regina Ribeiro de Castro ◽  
Romeu Rodrigues de Souza ◽  
Laura Beatriz Mesiano Maifrino ◽  
Ricardo Aparecido Baptista Nucci ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Wistar Rats ◽  
Female Rats ◽  
Male Rats ◽  
Aged Rats ◽  
Femoral Bone ◽  
Middle Aged ◽  
Left Femur ◽  
Bone Stiffness ◽  
The Right

Abstract Introduction Study of the variations of bone characteristics with age in different animal models is important to design musculoskeletal studies. Thus, this study aimed to evaluate the bone mass, dimensions, and biomechanical parameters of the femur in young, middle-aged, and aged Wistar rats. Materials and Methods Thirty male rats (Rattus norvegicus) were divided in three groups (n = 10 per group)—3-month-old young rats, 12-month-old middle-aged rats, and 18-months-old aged rats. The right femurs were subjected sequentially to morphometric study (bone weight, cortical thickness) and biomechanical tests (maximum resistance strength and bone stiffness). Results We observed a significant increase in femur histological (cortical thickness) and biomechanical (maximum strength and bone stiffness) parameters with aging when compared with young animals. Conclusions With the advancing age, the right femoral bone of middle-aged and old animals had greater variations when compared with young animals. However, further studies with the aid of a comparison between right and left femur and other long bones in both male and female rats are needed to corroborate with our findings.

A Reduction in Behavioral Pattern Separation Is Attenuated by Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend in Middle-Aged Rats

2021 ◽  
Author(s):  
Erin K. Crowley ◽  
Stefanie Grabrucker ◽  
Caitriona M. Long-Smith ◽  
Alice Stack ◽  
Denise M. O'Gorman ◽  
...  
Keyword(s):  
Dietary Supplementation ◽  
Behavioral Pattern ◽  
Pattern Separation ◽  
Aged Rats ◽  
Middle Aged

Effects of Gossypium herbaceam Extract Administration on the Learning and Memory Function in the Naturally Aged Rats: Neuronal Niche Improvement1

2012 ◽  
Vol 31 (1) ◽  
pp. 101-111 ◽  
Author(s):  
Yanyong Liu ◽  
Haji Akber Aisa ◽  
Chao Ji ◽  
Nan Yang ◽  
Haibo Zhu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Learning And Memory ◽  
Memory Impairment ◽  
Neuroprotective Effect ◽  
Memory Function ◽  
Aged Rats

Aging-associated cognitive impairment is an important health care issue since individuals with mild cognitive impairment are more likely to develop Alzheimer’s disease. In the present study, the protective effect of Gossypium herbaceam extracts (GHE) on learning and memory impairment associated with aging were examined in vivo using Morris water maze and step through task. Furthermore, the antioxidant activity and neuroprotective effect of GHE was investigated with methods of histochemistry and biochemistry. These data showed that oral administration with GHE at the doses of 35, 70, and 140 mg/kg exerted an improved effect on the learning and memory impairment in aged rats. Subsequently, GHE afforded a beneficial action on eradication of free radicals without influence on the activity of glutathione peroxidase and superoxide dismutase. GHE treatment enhanced the expression levels of nerve growth factor. Meanwhile, proliferation of neural progenitor cells was elevated in hippocampus after treatment with GHE. Taken together, neurogenic niche improvement could be involved in the mechanism underlying neuroprotection of GHE against aging-associated cognitive impairment. These findings suggested that GHE might be a potential agent as cognitive-enhancing drugs that delay or halt mild cognitive impairment progression to Alzheimer’s disease or treatment of aging-associated cognitive impairment.

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