Can dryad explain age-related associative memory deficits?

2016 ◽  
Vol 31 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Andrea C. Smyth ◽  
Moshe Naveh-Benjamin
Keyword(s):  
Associative Memory ◽  
Memory Deficits ◽  
Age Related

scholarly journals Integrative and semantic relations equally alleviate age-related associative memory deficits.

2012 ◽  
Vol 27 (1) ◽  
pp. 141-152 ◽  
Author(s):  
Stephen P. Badham ◽  
Zachary Estes ◽  
Elizabeth A. Maylor
Keyword(s):  
Associative Memory ◽  
Memory Deficits ◽  
Semantic Relations ◽  
Age Related

scholarly journals Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing

2021 ◽  
Author(s):  
Sujeong Yang ◽  
Sylvain Gigout ◽  
Angelo Molinaro ◽  
Yuko Naito-Matsui ◽  
Sam Hilton ◽  
...  
Keyword(s):  
Chondroitin Sulphate ◽  
Memory Loss ◽  
Memory Deficits ◽  
Long Term Potentiation ◽  
Aged Mice ◽  
Age Related ◽  
Term Potentiation ◽  
Early Memory

AbstractPerineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice. We first confirmed that aged mice (20-months) showed memory and plasticity deficits. They were able to retain or regain their cognitive ability when CSs were digested or PNNs were attenuated. We then explored the role of C6S in memory and neuroplasticity. Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains. These animals showed very early memory loss at 11 weeks old. Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.

Age-related emotional bias in associative memory consolidation: The role of sleep

2020 ◽  
Vol 171 ◽  
pp. 107204 ◽  
Author(s):  
Sheng-Yin Huan ◽  
Kun-Peng Liu ◽  
Xu Lei ◽  
Jing Yu
Keyword(s):  
Associative Memory ◽  
Memory Consolidation ◽  
Age Related ◽  
Emotional Bias
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