Review of Self-administration of abused substances: Methods for study. National Institute on Drug Abuse Research Monograph 20.

1979 ◽  
Vol 24 (5) ◽  
pp. 436-436
Author(s):  
PHILIP M. GROVES
Keyword(s):  
Drug Abuse ◽  
Self Administration

Contingency management approaches to drug self-administration and drug abuse: Efficacy and limitations

1981 ◽  
Vol 6 (3) ◽  
pp. 241-252 ◽  
Author(s):  
George E. Bigelow ◽  
Maxine L. Stitzer ◽  
Roland R. Griffiths ◽  
Ira A. Liebson
Keyword(s):  
Drug Abuse ◽  
Contingency Management ◽  
Self Administration ◽  
Management Approaches

Cocaine self-administration in rats influenced by environmental conditions: implications for the etiology of drug abuse

1987 ◽  
Vol 81 (1-2) ◽  
pp. 227-231 ◽  
Author(s):  
Susan Schenk ◽  
Gary Lacelle ◽  
Kathleen Gorman ◽  
Zalman Amit
Keyword(s):  
Drug Abuse ◽  
Environmental Conditions ◽  
Self Administration

Reinstatement of punishment-suppressed opioid self-administration in rats: an alternative model of relapse to drug abuse

2002 ◽  
Vol 168 (1-2) ◽  
pp. 229-235 ◽  
Author(s):  
Leigh V. Panlilio ◽  
Eric B. Thorndike ◽  
Charles W. Schindler
Keyword(s):  
Drug Abuse ◽  
Alternative Model ◽  
Self Administration

scholarly journals Do Prenatally Methamphetamine-Exposed Adult Male Rats Display General Predisposition to Drug Abuse in the Conditioned Place Preference Test?

2012 ◽  
pp. S129-S138
Author(s):  
R. ŠLAMBEROVÁ ◽  
M. POMETLOVÁ ◽  
B. SCHUTOVÁ ◽  
L. HRUBÁ ◽  
E. MACÚCHOVÁ ◽  
...  
Keyword(s):  
Drug Abuse ◽  
Pregnant Women ◽  
Conditioned Place Preference ◽  
Adult Male ◽  
Place Preference ◽  
Male Rats ◽  
Self Administration ◽  
Adult Rats ◽  
Drug Seeking ◽  
Seeking Behavior

Drug abuse of pregnant women is a growing problem. The effect of prenatal drug exposure may have devastating effect on development of the offsprings that may be long-term or even permanent. One of the most common drug abused by pregnant women is methamphetamine (MA), which is also the most frequently abused illicit drug in the Czech Republic. Our previous studies demonstrated that prenatal MA exposure alters behavior, cognition, pain and seizures in adult rats in sex-specific manner. Our most recent studies demonstrate that prenatal MA exposure makes adult rats more sensitive to acute injection of the same or related drugs than their controls. The aim of the present study was to examine the effect of prenatal MA exposure on drug-seeking behavior of adult male rats tested in the Conditioned place preference (CPP). Adult male rats were divided to: prenatally MA-exposed (5 mg/kg daily for the entire prenatal period), prenatally saline-exposed (1 ml/kg of physiological saline) and controls (without maternal injections). The following drugs were used in the CPP test in adulthood: MA (5 mg/kg), amphetamine (5 mg/kg), cocaine (5 and 10 mg/kg), morphine (5 mg/kg), MDMA (5 mg/kg) and THC (2 mg/kg). Our data demonstrated that prenatally MA-exposed rats displayed higher amphetamine-seeking behavior than both controls. MA as well as morphine induced drug-seeking behavior of adult male rats, however this effect did not differ based on the prenatal MA exposure. In contrast, prenatal MA exposure induced rather tolerance to cocaine than sensitization after the conditioning in the CPP. MDMA and THC did not induce significant effects. Even though the present data did not fully confirmed our hypotheses, future studies are planned to test the drug-seeking behavior also in self-administration test.

scholarly journals Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice

2013 ◽  
Vol 16 (7) ◽  
pp. 1559-1567 ◽  
Author(s):  
Yijin Yan ◽  
Yoshiaki Miyamoto ◽  
Atsumi Nitta ◽  
Shin-ichi Muramatsu ◽  
Keiya Ozawa ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Drug Abuse ◽  
Locomotor Activity ◽  
Gene Transfer ◽  
Mouse Models ◽  
Clinical Settings ◽  
Self Administration ◽  
Adeno Associated Virus ◽  
Gdnf Gene ◽  
The Brain

Abstract Relapse of drug abuse after abstinence is a major challenge to the treatment of addicts. In our well-established mouse models of methamphetamine (Meth) self-administration and reinstatement, bilateral microinjection of adeno-associated virus vectors expressing GDNF (AAV-Gdnf) into the striatum significantly reduced Meth self-administration, without affecting locomotor activity. Moreover, the intrastriatal AAV-Gdnf attenuated cue-induced reinstatement of Meth-seeking behaviour in a sustainable manner. In addition, this manipulation showed that Meth-primed reinstatement of Meth-seeking behaviour was reduced. These findings suggest that the AAV vector-mediated Gdnf gene transfer into the striatum is an effective and sustainable approach to attenuate Meth self-administration and Meth-associated cue-induced relapsing behaviour and that the AAV-mediated Gdnf gene transfer in the brain may be a valuable gene therapy against drug dependence and protracted relapse in clinical settings.

Drug Abuse Down in U.S. Kids, Federal Study Says

2006 ◽  
Vol 40 (10) ◽  
pp. 28
Author(s):  
JOHN R. BELL
Keyword(s):  
Drug Abuse
Sign in / Sign up

Export Citation Format

Share Document