scholarly journals Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: Effects of saccharin preference, impulsivity, and sex

2013 ◽  
Vol 122 ◽  
pp. 32-38 ◽  
Author(s):  
Nathan A. Holtz ◽  
Justin J. Anker ◽  
Paul S. Regier ◽  
Alex Claxton ◽  
Marilyn E. Carroll
Keyword(s):  
Drug Abuse ◽  
Saccharin Preference ◽  
Self Administration ◽  
Rat Models

Contingency management approaches to drug self-administration and drug abuse: Efficacy and limitations

1981 ◽  
Vol 6 (3) ◽  
pp. 241-252 ◽  
Author(s):  
George E. Bigelow ◽  
Maxine L. Stitzer ◽  
Roland R. Griffiths ◽  
Ira A. Liebson
Keyword(s):  
Drug Abuse ◽  
Contingency Management ◽  
Self Administration ◽  
Management Approaches

Cocaine self-administration in rats influenced by environmental conditions: implications for the etiology of drug abuse

1987 ◽  
Vol 81 (1-2) ◽  
pp. 227-231 ◽  
Author(s):  
Susan Schenk ◽  
Gary Lacelle ◽  
Kathleen Gorman ◽  
Zalman Amit
Keyword(s):  
Drug Abuse ◽  
Environmental Conditions ◽  
Self Administration

Reinstatement of punishment-suppressed opioid self-administration in rats: an alternative model of relapse to drug abuse

2002 ◽  
Vol 168 (1-2) ◽  
pp. 229-235 ◽  
Author(s):  
Leigh V. Panlilio ◽  
Eric B. Thorndike ◽  
Charles W. Schindler
Keyword(s):  
Drug Abuse ◽  
Alternative Model ◽  
Self Administration

scholarly journals Relapse to cotinine seeking in rats: Differential effects of sex

2021 ◽  
Author(s):  
Xiaoying Tan ◽  
Elizabeth Neslund ◽  
Zheng-Ming Ding
Keyword(s):  
Female Rats ◽  
Male Rats ◽  
Potential Mechanism ◽  
Self Administration ◽  
Drug Seeking ◽  
Male And Female ◽  
Rat Models ◽  
Significant Challenge ◽  
Male And Female Rats ◽  
Future Treatments

Relapse is a defining feature of smoking and a significant challenge in cessation management. Elucidation of novel mechanisms underlying relapse may inform future treatments. Cotinine, the major metabolite of nicotine, has been shown to support intravenous self-administration in rats, suggesting it as one potential mechanism contributing to nicotine reinforcement. However, it remains unknown whether cotinine would induce relapse-like behaviors. The current study investigated relapse to cotinine seeking in two relapse models, the reinstatement of drug seeking and incubation of drug craving models. In the reinstatement model, rats were trained to self-administer cotinine, extinguished cotinine-associated responses, and underwent cue-, drug-, or stress-induced reinstatement. Conditioned cues associated with cotinine self-administration, cotinine (1-2 mg/kg), or the pharmacological stressor yohimbine (1.25-2.5 mg/kg) reinstated cotinine seeking. Female rats displayed more pronounced cue-induced, but not drug- or stress-induced reinstatement than male rats. In addition, an overall analysis revealed that female rats exhibited greater cotinine self-administration, but less extinction than male rats. In the incubation model, rats were trained to self-administer cotinine, and underwent forced withdrawal in home cages. Rats were tested for cue-induced cotinine seeking on both withdrawal day 1 and withdrawal day 18. Rats exhibited greater cotinine-seeking on withdrawal day 18 compared to withdrawal day 1, with no difference between male and female rats. These findings indicate that cotinine induces sex-dependent relapse to cotinine seeking in rats, suggesting that cotinine may be a novel mechanism contributing to relapse. These rat models are valuable preclinical tools for interrogation of neurobiological underpinnings of relapse to cotinine seeking.

scholarly journals Do Prenatally Methamphetamine-Exposed Adult Male Rats Display General Predisposition to Drug Abuse in the Conditioned Place Preference Test?

2012 ◽  
pp. S129-S138
Author(s):  
R. ŠLAMBEROVÁ ◽  
M. POMETLOVÁ ◽  
B. SCHUTOVÁ ◽  
L. HRUBÁ ◽  
E. MACÚCHOVÁ ◽  
...  
Keyword(s):  
Drug Abuse ◽  
Pregnant Women ◽  
Conditioned Place Preference ◽  
Adult Male ◽  
Place Preference ◽  
Male Rats ◽  
Self Administration ◽  
Adult Rats ◽  
Drug Seeking ◽  
Seeking Behavior

Drug abuse of pregnant women is a growing problem. The effect of prenatal drug exposure may have devastating effect on development of the offsprings that may be long-term or even permanent. One of the most common drug abused by pregnant women is methamphetamine (MA), which is also the most frequently abused illicit drug in the Czech Republic. Our previous studies demonstrated that prenatal MA exposure alters behavior, cognition, pain and seizures in adult rats in sex-specific manner. Our most recent studies demonstrate that prenatal MA exposure makes adult rats more sensitive to acute injection of the same or related drugs than their controls. The aim of the present study was to examine the effect of prenatal MA exposure on drug-seeking behavior of adult male rats tested in the Conditioned place preference (CPP). Adult male rats were divided to: prenatally MA-exposed (5 mg/kg daily for the entire prenatal period), prenatally saline-exposed (1 ml/kg of physiological saline) and controls (without maternal injections). The following drugs were used in the CPP test in adulthood: MA (5 mg/kg), amphetamine (5 mg/kg), cocaine (5 and 10 mg/kg), morphine (5 mg/kg), MDMA (5 mg/kg) and THC (2 mg/kg). Our data demonstrated that prenatally MA-exposed rats displayed higher amphetamine-seeking behavior than both controls. MA as well as morphine induced drug-seeking behavior of adult male rats, however this effect did not differ based on the prenatal MA exposure. In contrast, prenatal MA exposure induced rather tolerance to cocaine than sensitization after the conditioning in the CPP. MDMA and THC did not induce significant effects. Even though the present data did not fully confirmed our hypotheses, future studies are planned to test the drug-seeking behavior also in self-administration test.

Saccharin Preference in Rats: Relation to Impulsivity and Drug Abuse

2012 ◽  
pp. 201-233 ◽  
Author(s):  
Marilyn E. Carroll ◽  
Nathan A. Holtz ◽  
Natalie E. Zlebnik
Keyword(s):  
Drug Abuse ◽  
Saccharin Preference

scholarly journals Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice

2013 ◽  
Vol 16 (7) ◽  
pp. 1559-1567 ◽  
Author(s):  
Yijin Yan ◽  
Yoshiaki Miyamoto ◽  
Atsumi Nitta ◽  
Shin-ichi Muramatsu ◽  
Keiya Ozawa ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Drug Abuse ◽  
Locomotor Activity ◽  
Gene Transfer ◽  
Mouse Models ◽  
Clinical Settings ◽  
Self Administration ◽  
Adeno Associated Virus ◽  
Gdnf Gene ◽  
The Brain

Abstract Relapse of drug abuse after abstinence is a major challenge to the treatment of addicts. In our well-established mouse models of methamphetamine (Meth) self-administration and reinstatement, bilateral microinjection of adeno-associated virus vectors expressing GDNF (AAV-Gdnf) into the striatum significantly reduced Meth self-administration, without affecting locomotor activity. Moreover, the intrastriatal AAV-Gdnf attenuated cue-induced reinstatement of Meth-seeking behaviour in a sustainable manner. In addition, this manipulation showed that Meth-primed reinstatement of Meth-seeking behaviour was reduced. These findings suggest that the AAV vector-mediated Gdnf gene transfer into the striatum is an effective and sustainable approach to attenuate Meth self-administration and Meth-associated cue-induced relapsing behaviour and that the AAV-mediated Gdnf gene transfer in the brain may be a valuable gene therapy against drug dependence and protracted relapse in clinical settings.

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