scholarly journals Do Prenatally Methamphetamine-Exposed Adult Male Rats Display General Predisposition to Drug Abuse in the Conditioned Place Preference Test?

2012 ◽  
pp. S129-S138
Author(s):  
R. ŠLAMBEROVÁ ◽  
M. POMETLOVÁ ◽  
B. SCHUTOVÁ ◽  
L. HRUBÁ ◽  
E. MACÚCHOVÁ ◽  
...  
Keyword(s):  
Drug Abuse ◽  
Pregnant Women ◽  
Conditioned Place Preference ◽  
Adult Male ◽  
Place Preference ◽  
Male Rats ◽  
Self Administration ◽  
Adult Rats ◽  
Drug Seeking ◽  
Seeking Behavior

Drug abuse of pregnant women is a growing problem. The effect of prenatal drug exposure may have devastating effect on development of the offsprings that may be long-term or even permanent. One of the most common drug abused by pregnant women is methamphetamine (MA), which is also the most frequently abused illicit drug in the Czech Republic. Our previous studies demonstrated that prenatal MA exposure alters behavior, cognition, pain and seizures in adult rats in sex-specific manner. Our most recent studies demonstrate that prenatal MA exposure makes adult rats more sensitive to acute injection of the same or related drugs than their controls. The aim of the present study was to examine the effect of prenatal MA exposure on drug-seeking behavior of adult male rats tested in the Conditioned place preference (CPP). Adult male rats were divided to: prenatally MA-exposed (5 mg/kg daily for the entire prenatal period), prenatally saline-exposed (1 ml/kg of physiological saline) and controls (without maternal injections). The following drugs were used in the CPP test in adulthood: MA (5 mg/kg), amphetamine (5 mg/kg), cocaine (5 and 10 mg/kg), morphine (5 mg/kg), MDMA (5 mg/kg) and THC (2 mg/kg). Our data demonstrated that prenatally MA-exposed rats displayed higher amphetamine-seeking behavior than both controls. MA as well as morphine induced drug-seeking behavior of adult male rats, however this effect did not differ based on the prenatal MA exposure. In contrast, prenatal MA exposure induced rather tolerance to cocaine than sensitization after the conditioning in the CPP. MDMA and THC did not induce significant effects. Even though the present data did not fully confirmed our hypotheses, future studies are planned to test the drug-seeking behavior also in self-administration test.

scholarly journals Conditioned Place Preference and Self-Administration Induced by Nicotine in Adolescent and Adult Rats

2014 ◽  
Vol 22 (5) ◽  
pp. 460-466 ◽  
Author(s):  
Hafiz Muhammad Ahsan ◽  
June Bryan I. de la Peña ◽  
Chrislean Jun Botanas ◽  
Hee Jin Kim ◽  
Gu Yong Yu ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Self Administration ◽  
Adult Rats

scholarly journals Early methylphenidate exposure enhances cocaine self-administration but not cocaine-induced conditioned place preference in young adult rats

2010 ◽  
Vol 213 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Cynthia A. Crawford ◽  
Shelley A. Baella ◽  
Cristal M. Farley ◽  
Matthew S. Herbert ◽  
Leslie R. Horn ◽  
...  
Keyword(s):  
Young Adult ◽  
Conditioned Place Preference ◽  
Place Preference ◽  
Self Administration ◽  
Adult Rats

scholarly journals Attenuation of Methamphetamine-Induced conditioned place preference in Mice after a Drug-Free period and Facilitation of this effect by exposure to a Running Wheel

2012 ◽  
Vol 6 ◽  
pp. JEN.S10046 ◽  
Author(s):  
Nobue Kitanaka ◽  
Junichi Kitanaka ◽  
F. Scott Hall ◽  
George R. Uhl ◽  
Kaname Watabe ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Running Wheel ◽  
Drug Seeking ◽  
Testing Procedures ◽  
Seeking Behavior ◽  
Group A ◽  
Locomotor Activities ◽  
Group B ◽  
Drug Free

The effect of exposure of male mice to a horizontal running wheel (Fast-Trac™) on conditioned place preference (CPP) and hyperlocomotion induced by methamphetamine (METH) was determined. In the first experiment eleven-week-old male ICR mice were divided into three groups and exposed to three different environments (housed individually with (group A) or without a running wheel (group B), or housed in a group of eight mice without a running wheel (group C)) for two weeks except during periods of CPP conditioning and testing procedures. Administration of METH (0.5 mg/kg, i.p.) every other day during three conditioning sessions, with saline conditioning sessions in the other compartment on alternate days (ie, saline/METH conditioning), induced a significant CPP, compared to saline/saline conditioning, in mice of groups A and C, but not B. The increased CPP for METH was significantly attenuated by additional 5-day (drug-free)-exposure to a running wheel in mice of group A (but not group C). In the second experiment, pre-exposure of another set of mice to a running wheel for three days did not affect a subsequent METH (1.0 mg/kg)- or saline-induced horizontal locomotion or rearing, compared with the locomotor activities observed in mice without an experience of a running wheel. These observations suggest that experience of a running wheel may selectively facilitate an attenuation of drug-seeking behavior.

scholarly journals Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats

2014 ◽  
Vol 124 ◽  
pp. 320-325 ◽  
Author(s):  
Deanne M. Buffalari ◽  
Nana Yaa A. Marfo ◽  
Tracy T. Smith ◽  
Melissa E. Levin ◽  
Matthew T. Weaver ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Adult Male ◽  
Place Preference ◽  
Male Rats

scholarly journals Methamphetamine self-administration in a runway model of drug-seeking behavior in male rats

2018 ◽  
Vol 175 ◽  
pp. 27-32
Author(s):  
Mona Akhiary ◽  
Erin M. Purvis ◽  
Adam K. Klein ◽  
Aaron Ettenberg
Keyword(s):  
Male Rats ◽  
Self Administration ◽  
Drug Seeking ◽  
Seeking Behavior

Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats?

2011 ◽  
Vol 224 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Romana Šlamberová ◽  
Barbora Schutová ◽  
Lenka Hrubá ◽  
Marie Pometlová
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Drug Seeking ◽  
Seeking Behavior

scholarly journals Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis

2019 ◽  
Author(s):  
Dipanwita Pati ◽  
Melanie M. Pina ◽  
Thomas L. Kash
Keyword(s):  
Conditioned Place Preference ◽  
Drugs Of Abuse ◽  
Ex Vivo ◽  
Glutamate Release ◽  
Place Preference ◽  
Place Conditioning ◽  
Stria Terminalis ◽  
Drug Seeking ◽  
Bed Nucleus ◽  
Seeking Behavior

AbstractContextual cues associated with drugs of abuse, such as ethanol, can trigger craving and drug seeking behavior. Pavlovian procedures, such as place conditioning, have been widely used to study the rewarding/aversive properties of drugs and the association between environmental cues and drug seeking. Previous research has shown that ethanol as an unconditioned stimulus can induce a strong conditioned place preference (CPP) or aversion (CPA) in rodents. However, the neural mechanisms underlying ethanol induced reward and aversion have not been thoroughly investigated. The bed nucleus of the stria terminalis (BNST), an integral part of the extended amygdala, is engaged by both rewarding and aversive stimuli and plays a role in ethanol seeking behavior. Here, we used ex-vivo slice physiology to probe learning-induced synaptic plasticity in the BNST following ethanol-induced CPP and CPA. Male DBA/2J mice (2-3 months old) were conditioned using previously reported ethanol-induced CPP/CPA procedures. Ethanol-induced CPP was associated with increased neuronal excitability in the ventral BNST (vBNST). Conversely, ethanol-induced CPA resulted in a significant decrease in spontaneous glutamatergic transmission without alterations in GABAergic signaling. Ethanol-CPA also led to significant increase in paired pulse ratio at excitatory synapses, suggestive of a decrease in presynaptic glutamate release. Collectively, these data demonstrate that the vBNST is involved in the modulation of contextual learning associated with both the rewarding and the aversive properties of ethanol in mice.

scholarly journals Extinction and drug‐induced reinstatement of cocaine seeking following self‐administration or conditioned place preference in adolescent and adult rats

2020 ◽  
Vol 63 (1) ◽  
pp. 125-137 ◽  
Author(s):  
Alexandre A. Guerin ◽  
Isabel C. Zbukvic ◽  
Sophia J. Luikinga ◽  
Katherine D. Drummond ◽  
Andrew J. Lawrence ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Self Administration ◽  
Drug Induced ◽  
Adult Rats ◽  
Cocaine Seeking

scholarly journals Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

2012 ◽  
Vol 113 (3) ◽  
pp. 189-205 ◽  
Author(s):  
Romana Šlamberová ◽  
A. Yamamotová ◽  
M. Pometlová ◽  
B. Schutová ◽  
L. Hrubá ◽  
...  
Keyword(s):  
Adult Male ◽  
Analgesic Effect ◽  
Drug Exposure ◽  
Prenatal Drug Exposure ◽  
Male Rats ◽  
Daily Injection ◽  
Challenge Dose ◽  
Drug Seeking ◽  
Seeking Behavior ◽  
Plantar Test

The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to challenge dose of cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA- or saline-exposed) were divided to groups with challenge doses of saline (1 ml/kg), cocaine (5 mg/kg) or morphine (5 mg/kg). Behavior in unknown environment was examined in Laboras, nociception in Plantar test, and active drug-seeking behavior in conditioned place preference (CPP). Our data demonstrate that cocaine increased the exploratory activity in Laboras test in prenatally saline-exposed, but decreased it in prenatally MA-exposed rats. An analgesic effect of cocaine was demonstrated only by the tail withdrawal and it was independent of the prenatal drug exposure. CPP test showed that prenatal MA exposure induced rather tolerance than sensitization to cocaine. In contrast to cocaine effects, morphine decreased rearing activity in both, prenatally MA-exposed and saline-exposed rats, and locomotion only in prenatally MA-exposed rats in the Laboras. In the Plantar test, the results demonstrated that morphine had an analgesic effect in prenatally saline-exposed rats but this effect was suppressed in prenatally MA-exposed rats. In the CPP test morphine induced drug-seeking behavior, which however was not affected by prenatal drug exposure. Thus, our data demonstrate that there is a cross-effect between prenatal MA exposure and the challenge dose of other drug in adulthood, however drug-seeking behavior is not increased by prenatal MA exposure as we expected.

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