Metabonomic Study of Ochratoxin A Toxicity in Rats after Repeated Administration: Phenotypic Anchoring Enhances the Ability for Biomarker Discovery

2009 ◽  
Vol 22 (7) ◽  
pp. 1221-1231 ◽  
Author(s):  
Maximilian Sieber ◽  
Silvia Wagner ◽  
Eva Rached ◽  
Alexander Amberg ◽  
Angela Mally ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Biomarker Discovery ◽  
Repeated Administration ◽  
Phenotypic Anchoring

Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration

2008 ◽  
Vol 230 (2) ◽  
pp. 197-207 ◽  
Author(s):  
Leire Arbillaga ◽  
Ariane Vettorazzi ◽  
Ana G Gil ◽  
Joost HM van Delft ◽  
José Antonio García-Jalón ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ochratoxin A ◽  
Repeated Administration ◽  
F344 Rat

Nucleolar Segregation and Chronic Methanol Intoxication

1969 ◽  
Vol 27 ◽  
pp. 360-361
Author(s):  
Julio H. Garcia ◽  
Janice P. Van Zandt
Keyword(s):  
Body Weight ◽  
Methyl Alcohol ◽  
Rhesus Monkeys ◽  
Repeated Administration ◽  
Serum Levels ◽  
Methanol Intoxication ◽  
Intragastric Tube ◽  
Nucleolar Segregation

Repeated administration of methyl alcohol to Rhesus monkeys (Maccaca mulata) by intragastric tube resulted in ultrastructural abnormalities of hepatocytes, which persisted in one animal twelve weeks after discontinuation of the methyl alcohol regime. With dosages ranging between 3.0 to 6.0 gms. of methanol per kg. of body weight, the serum levels attained within a few hours averaged approximately 475 mg. per cent.

Lobeline shows a specific antiaggressive effect after repeated administration

2000 ◽  
Author(s):  
M. C. Oterino ◽  
I. Moragrega ◽  
P. Vicens ◽  
M. C. Carrasco ◽  
R. Redolat ◽  
...  
Keyword(s):  
Repeated Administration

HES 200/0.5 Is not HES 200/0.5

1995 ◽  
Vol 74 (06) ◽  
pp. 1452-1456 ◽  
Author(s):  
Johannes Treib ◽  
Anton Haass ◽  
Gerhard Pindur ◽  
Ulrich T Seyfert ◽  
Wolfgang Treib ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Hydroxyethyl Starch ◽  
Clinical Relevance ◽  
Dilution Effect ◽  
Repeated Administration ◽  
Plasma Viscosity ◽  
Degree Of Substitution ◽  
Pronounced Increase ◽  
Large Molecules ◽  
Mean Molecular Weight

SummaryThe plasma clearance of hydroxyethyl starch (HES) depends on the initial molecular weight and the degree of substitution. So far, little attention has been paid to the clinical relevance of the C2/C6 substitution ratio of hydroxyethyl starch.10 patients with cerebrovascular circulatory disturbance received hemodilution therapy for 10 days, consisting of 10% HES 200/0.5 (mean molecular weight 200 kD, degree of substitution 0.5) with a C2/C6 ratio of 13.4. A second group of 10 patients received a starch solution with identical initial molecular weight and degree of substitution but with a C2/C6 ratio of 5.7.After the administration of a single dose, no significant differences between the two groups were observed. After repeated administration, significant differences could be detected in hemorheology, coagulation and elimination (p<0.01). The larger C2/C6 ratio led to a higher intravascular mean molecular weight (95 vs. 84 kD), which in turn led to a higher increase in serum concentration during the therapy (14.7 vs.8.6 mg/ml). Hematocrit was lowered more (-30,5 vs. -23,5%) and plasma viscosity was increased more. There was also a more pronounced increase in partial thromboplastin time (+30% vs. +13%) and a factor of 2 larger decrease of factor VIII/von Willebrand factor-complex (p <0.01), which exceeded the dilution effect.The higher C2/C6 ratio of HES 200/0.5/13.4 slows down enzymatic degradation. After repeated administration of this starch, large molecules accumulate which are inefficiently degraded. The same effect has been observed after therapy with highly-substituted HES. This accumulation of large molecules leads to a beneficial longer lasting volume effect. The disadvantages include an increase in plasma viscosity and coagulation disturbances, which cannot be explained with the respective dilution effect alone. For these reasons, the C2/C6 ratio is of clinical relevance and should be included in the product labeling in the future.

Intoxication with Phenprocoumon (Marcoumar) Pharmacokinetics and Side Effects

1969 ◽  
Vol 21 (02) ◽  
pp. 320-324 ◽  
Author(s):  
K Seiler ◽  
F Duckert
Keyword(s):  
Plasma Concentration ◽  
Side Effects ◽  
Half Life ◽  
Plasma Proteins ◽  
Repeated Administration ◽  
High Plasma ◽  
Vitamin K1 ◽  
Clotting Factors ◽  
Therapeutic Concentration ◽  
High Plasma Concentration

SummaryA case of severe Marcoumar intoxication is described. Eleven hours after the intake a plasma concentration of 15.75 µg/ml was found which corresponds approximately to the 5-fold therapeutic concentration. Repeated administration of vitamin K1 made it possible to avoid extreme lowering of the activity of the clotting factors II, VII and X and to prevent bleeding. Side effects were not observed. The biologic half-life of Phenprocoumon has been found to be shortened at high plasma concentration (3.7 instead of 5.9 days). It is probable that in extreme concentration the drug is less strongly bound to the plasma proteins.

Lauric Acid-Induced Thrombocytopenia and Thrombosis in Rabbits

1967 ◽  
Vol 18 (01/02) ◽  
pp. 057-065 ◽  
Author(s):  
G Zbinden
Keyword(s):  
Acid Solution ◽  
Intravenous Injection ◽  
Lauric Acid ◽  
Repeated Administration ◽  
Intravenous Dose ◽  
Acid Injection ◽  
Small Doses ◽  
High Doses

SummaryIntravenous injection of 0.5% lauric acid solution into rabbits caused moderate to marked thrombocytopenia. With small doses (2.5 mg/kg) this thrombocyte decrease was reversible and microscopically demonstrable thrombosis in the lungs was only seen or suspected in a small number of rabbits 10 to 30 min after lauric acid injection. High doses were followed by partly reversible thrombocytopenia and by moderate to marked, sometimes lethal, thrombosis in the lungs still demonstrable 24 hrs after injection. Repeated administration of small doses of lauric acid did not lead to a depletion of the circulating thrombocytes. Thrombocytopenic response, however, appeared to be less pronounced after the second and subsequent injections. Studies with Cr51-labeled platelets indicate that during the reversible thrombocytopenia following a small intravenous dose of lauric acid platelets are retained in various organs, particularly the lungs.

Mycobiota of Czech wine grapes and occurrence of ochratoxin A and Alternaria mycotoxins in fresh grape juice, must and wine.

2007 ◽  
Vol 59 (2) ◽  
pp. 241-254 ◽  
Author(s):  
Vladimír Ostrý ◽  
Jarmila Škarková ◽  
Ivana Procházková ◽  
Alena Kubátová ◽  
František Malíř ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Grape Juice ◽  
Wine Grapes ◽  
Alternaria Mycotoxins

The Androgen Receptor chromatin landscape in prostate tumors: biomarker discovery and beyond

2016 ◽  
Author(s):  
Suzan Stelloo ◽  
Ekaterina Nevedomskaya ◽  
Karianne Schuurman ◽  
Lodewyk FA Wessels ◽  
Rui Henrique ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Biomarker Discovery ◽  
Prostate Tumors
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