Low Plasma Albumin Levels Are Associated with Increased Plasma Protein Glycation and HbA1c in Diabetes

2012 ◽  
Vol 11 (2) ◽  
pp. 1391-1396 ◽  
Author(s):  
Hemangi S. Bhonsle ◽  
Arvind M. Korwar ◽  
Sachin S. Kote ◽  
Sandeep B. Golegaonkar ◽  
Ashok D. Chougale ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Protein Glycation ◽  
Plasma Albumin

IDIOPATHIC HYPOPROTEINEMIA

PEDIATRICS ◽  
1952 ◽  
Vol 9 (6) ◽  
pp. 729-735
Author(s):  
JAMES B. WYNGAARDEN ◽  
JOHN D. CRAWFORD ◽  
HARRIE R. CHAMBERLIN ◽  
WALTER F. LEVER
Keyword(s):  
Weight Gain ◽  
Renal Impairment ◽  
Plasma Protein ◽  
Protein Metabolism ◽  
Unusual Case ◽  
Gamma Globulin ◽  
Serum Sickness ◽  
Mild Asthma ◽  
Plasma Albumin ◽  
Acute Tonsillitis

A 3½ year old Negro boy with an obscure syndrome of inexplicable, transient, acquired hypoproteinemia, involving plasma albumin and especially gamma globulin, has been observed. Edema, oliguria and weight gain were noted 10 days following an attack of acute tonsillitis. Hypertension, renal impairment, proteinuria and hematuria were conspicuously absent, and an associated eosinophilia subsided as recovery progressed. Plasma protein regeneration was complete in 10 weeks. The patient has since developed mild asthma but has otherwise remained well. This appears to be an unusual case of transient derangement of plasma protein metabolism. Possible relationships to the syndromes of acute nephritis without proteinuria, nephrosis, serum sickness and idiopathic acquired hypoproteinemia are discussed.

VITAMIN A TRANSPORT IN THE RAT

1966 ◽  
Vol 44 (4) ◽  
pp. 521-527 ◽  
Author(s):  
M. J. Veen ◽  
G. H. Beaton
Keyword(s):  
Vitamin A ◽  
Dose Level ◽  
Plasma Protein ◽  
Protein Concentration ◽  
Control Group ◽  
Plasma Vitamin ◽  
Plasma Albumin ◽  
Plasma Protein Concentration ◽  
Protein Group ◽  
Vitamin A Transport

Rats deficient in vitamin A and maintained on diets containing 0, 4, or 20% protein (casein) were repleted orally with 0, 10, 40, 80, or 160 μg vitamin A alcohol per day for 7 days. Plasma vitamin A rose with increasing amounts of administered vitamin A until a plateau was reached (at the dose level of 10 μg in the 0% protein group, and the dose level of 40 μg in the other groups), suggesting that plasma saturation with vitamin A had occurred. This was supported by an increase in the deposition of the vitamin in the liver at the dose level of 40 μg vitamin A. The actual level of plasma vitamin A attained at plasma saturation varied directly with the amount of dietary protein fed and, consequently, with plasma protein concentration, but was limited by food restriction in a control group fed a diet containing 20% protein to a level well below that obtained by a control group fed ad libitum with the same diet.Plasma vitamin A was shown to be statistically related to plasma albumin at all levels of administration of the vitamin, and to α1-globulin after plasma saturation with vitamin A had occurred.The data indicate the existence of a plasma protein carrier for vitamin A. The participation of an albumin subfraction in the transport mechanism is discussed.

scholarly journals Colloid Oncotic Pressure in Children with Nephrotic Syndrome

2019 ◽  
Vol 28 (9-10) ◽  
pp. 200-8
Author(s):  
Taralan Tambunan ◽  
H. Alatas ◽  
I. G. N. Wila Wirya ◽  
S. Harmanses ◽  
I. Chair ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Plasma Protein ◽  
Protein Concentration ◽  
Low Grade ◽  
Oncotic Pressure ◽  
Plasma Albumin ◽  
Plasma Protein Concentration ◽  
Strong Negative Correlation ◽  
Total Plasma Protein ◽  
Albumin Content

To evaluate the correlation between plasma protein concentration and colloid oncotic pressure (COP) and their influence on clinical symptom of edema, we studied 30 children with nephrotic syndrome (NS). Total plasma protein concentration (TP), albumm, globulin and COP were measured in all patients in edema forming state (EF) and m steady state phase (SS), except for COP, only 16 samples in SS phase. COP TP plasma albumin and globulin contents in EF group were 8. 7 ± 2. 7 mmHg, 4.07 '± 0.68 g/dl; 2.57 ± 0.50 g/dl and 1.51 ± 0.32 g/dl, respectively. In SS group these figures rose significantly to 16.7 ± 3.9 mmHg for COP; 5. 70 ± 0.99 g/dl for TP; 3.46 ± 0.52 g!dl and 2.06 ± 0.56 g/dl for plasma albumin and globulin, respectively. We also found the high correlation both between COP and albumin content (r= +0.58; p < 0.01) and between COP and TP (r= +0.54; P < 0.01) . A strong negative correlation was also found between COP and the degree of edema (r = _ 0.55; p <0.01). On the other hand a very low grade correlation was noticed between plasma albumin content and  the degree of edema (r= - 0.26; P < 0.05) and no correlation at all was found between edema and TP (r= - 0.19; P > 0.05). We conclude that COP has the highest correlation with plasma protein concentration and the degree of edema, and can be used as a diagnostic tool. It is even more sensitive and simple compared with the TP or albumin content determination.

Effects of Electroacupuncture on Leukocytes and Plasma Protein in the X-irradiated Rats

1984 ◽  
Vol 12 (01n04) ◽  
pp. 106-114 ◽  
Author(s):  
D.M. Hau
Keyword(s):  
Plasma Protein ◽  
Inhibitory Effect ◽  
Total Plasma ◽  
Plasma Albumin ◽  
X Ray ◽  
Total Plasma Protein ◽  
X Irradiation

The effects of electroacupunture on leukocytes and plasma protein on X ray-irradiated rats were investigated in the present study. The results showed that X-irradiation had an evident inhibitory effect on the counts of total leukocytes, lymphocytes and neutrocytes, and the concentration of the total plasma protein, plasma albumin, globulin and α- and β-globulin in X-irradiated rats. The electroacupuncture was able to help the X-irradiated rats to recover the counts of the total leukocyte, lymphocyte and neutrocyte. The electroacupuncture had a helpful tendency to recover the concentration of the total plasma protein, albumin, globulin, and α- and β-globulin in the irradiated rats.

Restricting sulfur amino acid intake in growing pigs challenged with lipopolysaccharides decreases plasma protein and albumin synthesis

2013 ◽  
Vol 93 (4) ◽  
pp. 505-515 ◽  
Author(s):  
N. Litvak ◽  
J. K. Htoo ◽  
C. F. M. de Lange
Keyword(s):  
Immune Response ◽  
Amino Acid ◽  
Plasma Protein ◽  
Growing Pigs ◽  
Sulfur Amino Acid ◽  
Albumin Synthesis ◽  
Plasma Albumin ◽  
Acid Intake ◽  
Lps Challenge ◽  
Amino Acid Intake

Litvak, N., Htoo, J. K. and de Lange, C. F. M. 2013. Restricting sulfur amino acid intake in growing pigs challenged with lipopolysaccharides decreases plasma protein and albumin synthesis. Can. J. Anim. Sci. 93: 505–515. Chronic subclinical levels of disease occur frequently in swine production and compromise nutrient utilization efficiency. Methionine and cysteine (M+C) are involved in the pig's response to immune system stimulation (ISS), acting as substrates for the synthesis of compounds involved in the immune response, such as acute phase proteins (APP). This study was conducted to determine the impact of ISS with lipopolysaccharide (LPS) and M+C intake (high vs. low; 4.0 vs. 2.2 g d−1) on the fractional synthesis rate (FSR) of plasma albumin and fibrinogen, as well as protein in plasma and various tissues of starter pigs. Fifteen pigs (9.8±1.4 kg body weight) were allotted to one of three treatments: (1) Control (LPS− and high M+C), (2) LPS+ and high M+C, or (3) LPS+ and low M+C. Pigs were given intramuscular injections of increasing doses of LPS 1 and 3 d before determining FSR using an intravenous infusion of a flooding dose of L-[ring−1H5]-phenylalanine. Plasma levels of APP were not affected by the LPS challenge (P>0.10); only plasma albumin levels decreased with reduced M+C intake (P=0.02). Total plasma protein FSR was increased during the LPS challenge (50.3 vs. 56.9% d−1, SEM = 1.6; P=0.01). Albumin FSR was not affected by an LPS challenge (P>0.10), but decreased with reduced M+C intake during the LPS challenge (49.5 vs. 41.9% d−1, SEM = 1.6; P=0.005). Spleen protein FSR tended to increase during the LPS challenge (P=0.08). There were no treatment effects on protein FSR in liver, small intestine, loin or plasma fibrinogen (P>0.10). Restricting M+C intake during a LPS challenge decreases albumin synthesis and tends to reduce plasma protein synthesis, implicating M+C as important nutrients involved in the immune response.

scholarly journals Hepatic protein synthesis in the sheep: effect of intake as by use of stable-isotope-labelled glycine, leucine and phenylalanine

1997 ◽  
Vol 77 (2) ◽  
pp. 255-271 ◽  
Author(s):  
A. Connell ◽  
A. G Calder ◽  
S. E Anderson ◽  
G. E Lobley*
Keyword(s):  
Protein Synthesis ◽  
Plasma Protein ◽  
Liver Protein ◽  
Plasma Samples ◽  
Total Plasma ◽  
Plasma Albumin ◽  
Total Plasma Protein ◽  
Significant Difference ◽  
Apolipoprotein B100 ◽  
Hepatic Portal

Rates of protein synthesis for the liver, plasma albumin and total plasma protein were quantified in sheep either offered a supra-maintenance intake or fasted for 3 d. The technique of continuous infusion over a 12 h period was employed with the simultaneous infusion of [1-13C]glycine, [1-13C]leucine and [2H5]phenylalanine. Blood and plasma samples were removed at timed intervals from the hepatic portal and hepatic veins plus the aorta. Enrichments of the free amino acids (AA) were determined in all blood and plasma samples as was the protein-bound AA in an apolipoprotein B100 extract. Protein-bound phenylalanine enrichments were also measured in albumin and total protein from plasma plus samples from liver biopsies. The apolipoprotein B100 enrichments agreed well with those of the free AA in hepatic (and hepatic portal) plasma but were lower than for arterial free AA and greater than liver homogenate free AA. This adds support to the concept that export proteins may preferentially use AA directly from extracellular sources. Intake had no significant effect on constitutive liver protein synthesis and the values agreed well with those obtained by other isotopic approaches. There were, however, signicant declines, based on hepatic venous free phenylalanine enrichment, at the lower intake in both the fractional (3·4v. 4·7 % per d;P=0·024) and absolute (2·4v. 4·2 g/d;P=0·011) synthesis rates of albumin, which matched the estimated decrease in total plasma albumin content (52v. 67 g,P<0·01). In contrast, there was a smaller reduction in total plasma protein mass (145v. 151 g,P=0·035) with no observed significant difference in kinetic parameters. Albumin synthesis was calculated to account for a maximum of 17 % of total liver protein synthesis in the fed condition and this may fall to 8 % during moderate fasts.

Changes in the concentration of plasma proteins in intensively bred ewes

1977 ◽  
Vol 88 (2) ◽  
pp. 283-288 ◽  
Author(s):  
W. S. Mackie
Keyword(s):  
Plasma Protein ◽  
Plasma Volume ◽  
Plasma Proteins ◽  
Gamma Globulin ◽  
Total Plasma ◽  
Plasma Albumin ◽  
Total Plasma Protein ◽  
The Mean ◽  
Mean Concentration ◽  
Intensive Breeding

SUMMARYThe mean concentration of plasma albumin in 30 Finnish Landrace x Dorset Horn ewes subjected to intensive breeding decreased as the number of pregnancies increased from three to seven; it also changed significantly within a pregnancy. Gamma globulin concentration was not affected by the number of pregnancies but decreased significantly within a pregnancy. Total plasma protein was affected like albumin by the number and stage of pregnancy.Plasma volume increased by 23 % in the latter third of pregnancy.

THE EFFECT OF AGE AND THE PLANE OF NUTRITION ON THE BLOOD CHEMISTRY OF THE COLUMBIAN BLACK-TAILED DEER (ODOCOILEUS HEMIONUS COLUMBIANUS): B. BLOOD GLUCOSE, NON-PROTEIN NITROGEN, TOTAL PLASMA PROTEIN, PLASMA ALBUMIN, GLOBULIN, AND FIBRINOGEN

1957 ◽  
Vol 35 (2) ◽  
pp. 283-289 ◽  
Author(s):  
P. J. Bandy ◽  
W. D. Kitts ◽  
A. J. Wood ◽  
I. McT. Cowan
Keyword(s):  
Blood Sugar ◽  
Plasma Protein ◽  
Odocoileus Hemionus ◽  
Blood Chemistry ◽  
Total Plasma ◽  
Odocoileus Hemionus Columbianus ◽  
Plasma Albumin ◽  
Protein Nitrogen ◽  
Blood Constituents ◽  
Total Plasma Protein

The blood sugar, non-protein nitrogen, total plasma protein, plasma albumin, globulin, and fibrinogen of the Columbian black-tailed deer have been studied on two series of animals reared on high and low planes of nutrition from birth to 465 days of age. Of these blood constituents only blood sugar and fibrinogen showed a measurable lowering in the low plane animals. Age changes have been noted that are independent of nutritive state but are similar to those reported for domestic ruminants.

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