scholarly journals Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice

2012 ◽  
Vol 11 (3) ◽  
pp. 1633-1643 ◽  
Author(s):  
Kristofer S. Fritz ◽  
James J. Galligan ◽  
Matthew D. Hirschey ◽  
Eric Verdin ◽  
Dennis R. Petersen
Keyword(s):  
Liver Injury ◽  
Mouse Model ◽  
Knockout Mice

626 P2Y2 Purinergic Receptor Knockout Mice Exhibit Increased Susceptibility to Liver Injury in a Mouse Model of Biliary Fibrosis

2010 ◽  
Vol 138 (5) ◽  
pp. S-791
Author(s):  
Samson Cantu ◽  
Arunmani Mani ◽  
Bryan Tackett ◽  
Moreshwar Desai ◽  
Sundararajah Thevananther
Keyword(s):  
Liver Injury ◽  
Mouse Model ◽  
Knockout Mice ◽  
Purinergic Receptor ◽  
Increased Susceptibility

Mitochondrial Acetylomic Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice

2011 ◽  
Vol 51 ◽  
pp. S19-S20
Author(s):  
Kristofer S. Fritz ◽  
James J. Galligan ◽  
Matthew D. Hirschey ◽  
Eric Verdin ◽  
Dennis R. Petersen
Keyword(s):  
Liver Injury ◽  
Mouse Model ◽  
Knockout Mice

NorUDCA improves liver injury and glucose sensitivity in a mouse model of obesity and steatosis

2015 ◽  
Vol 53 (05) ◽  
Author(s):  
D Steinacher ◽  
T Claudel ◽  
T Stojakovic ◽  
M Trauner
Keyword(s):  
Liver Injury ◽  
Mouse Model ◽  
Glucose Sensitivity

Geniposide suppresses liver injury in a mouse model of DDC ‐induced sclerosing cholangitis

2021 ◽  
Author(s):  
Min Wen ◽  
Yubei Liu ◽  
Ruiying Chen ◽  
Ping He ◽  
Feihua Wu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Mouse Model ◽  
Sclerosing Cholangitis

scholarly journals Characterization and Evaluation of HGF-Loaded PLGA Nanoparticles in a CCl4-Induced Acute Liver Injury Mouse Model

2019 ◽  
Vol 2019 ◽  
pp. 1-13
Author(s):  
Chuxi Lin ◽  
Xueer Wang ◽  
Nuyun Liu ◽  
Qing Peng ◽  
Yang Li ◽  
...  
Keyword(s):  
Liver Injury ◽  
Mouse Model ◽  
Acute Liver Injury ◽  
Redox Homeostasis ◽  
Plga Nanoparticles ◽  
Physical Characteristics ◽  
Sod Activity ◽  
Therapeutic Benefits ◽  
Antioxidant Proteins ◽  
Drug Free

Liver injury can be caused by various harmful factors since the liver is considered the key organ for detoxifying endogenous and exogenous substances. Hepatocyte growth factor (HGF) can regulate redox homeostasis through the expression of antioxidant proteins when the liver is under injury. However, HGF is easily degraded. In this study, we produced three kinds of HGF-loaded poly(lactic-co-glycolic) acid (PLGA) nanoparticles with an initial addition of 2 μg HGF (NPs-HGF-2 μg), 4 μg HGF (NPs-HGF-4 μg), and drug-free nanoparticles (NPs) using the W/O/W emulsion-solvent evaporation method in accordance with our patent. The morphology and physical characteristics were analyzed, and effects of HGF-loaded PLGA nanoparticles on a CCl4-induced acute liver injury mouse model were investigated and compared with HGF solutions. We observed that the morphology and the physical characteristics of the nanoparticles were almost the same, with similar sizes, polydispersity, and zeta potential. HGF-loaded PLGA nanoparticles maintained higher HGF concentrations for a longer period of time in blood and liver tissues. HGF-loaded PLGA nanoparticles increased the SOD activity and GPX levels, decreased the MDA levels in the liver, reduced the necrotic areas of the liver, and decreased the levels of AST, ALT, ALP, T-BIL, BUN, and Scr in blood. In conclusion, our technique for preparing HGF-loaded PLGA nanoparticles was stable and the products were of good quality. HGF-loaded PLGA nanoparticles could provide greater therapeutic benefits on CCl4-induced acute liver injury, including antilipid peroxidation and a reduction in indicator enzymes of liver injury.

scholarly journals Ascorbic Acid Attenuates Acute Ethanol-Induced Liver Injury in SMP30 Knockout Mice

2017 ◽  
Vol 08 (12) ◽  
pp. 1114-1126
Author(s):  
Eun-Mi Cho ◽  
H. M. Arif Ullah ◽  
Ahmed K. Elfadl ◽  
Myung-Jin Chung ◽  
Soong-Koo Kim ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Liver Injury ◽  
Knockout Mice ◽  
Acute Ethanol
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