scholarly journals Ascorbic Acid Attenuates Acute Ethanol-Induced Liver Injury in SMP30 Knockout Mice

2017 ◽  
Vol 08 (12) ◽  
pp. 1114-1126
Author(s):  
Eun-Mi Cho ◽  
H. M. Arif Ullah ◽  
Ahmed K. Elfadl ◽  
Myung-Jin Chung ◽  
Soong-Koo Kim ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Liver Injury ◽  
Knockout Mice ◽  
Acute Ethanol

Ascorbic acid and CoQ10 ameliorate the reproductive ability of superoxide dismutase 1-deficient female mice†

2019 ◽  
Author(s):  
Naoki Ishii ◽  
Takujiro Homma ◽  
Jaeyong Lee ◽  
Hikaru Mitsuhashi ◽  
Ken-ichi Yamada ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Superoxide Dismutase ◽  
Coenzyme Q10 ◽  
Knockout Mice ◽  
Knockout Mouse ◽  
Superoxide Dismutase 1 ◽  
Wild Type ◽  
Positive Effects ◽  
Reproductive Ability ◽  
Ascorbic Acid Supplementation

Abstract Superoxide dismutase 1 suppresses oxidative stress within cells by decreasing the levels of superoxide anions. A dysfunction of the ovary and/or an aberrant production of sex hormones are suspected causes for infertility in superoxide dismutase 1-knockout mice. We report on attempts to rescue the infertility in female knockout mice by providing two antioxidants, ascorbic acid and/or coenzyme Q10, as supplements in the drinking water of the knockout mice after weaning and on an investigation of their reproductive ability. On the first parturition, 80% of the untreated knockout mice produced smaller litter sizes compared with wild-type mice (average 2.8 vs 7.3 pups/mouse), and supplementing with these antioxidants failed to improve these litter sizes. However, in the second parturition of the knockout mice, the parturition rate was increased from 18% to 44–75% as the result of the administration of antioxidants. While plasma levels of progesterone at 7.5 days of pregnancy were essentially the same between the wild-type and knockout mice and were not changed by the supplementation of these antioxidants, sizes of corpus luteum cells, which were smaller in the knockout mouse ovaries after the first parturition, were significantly ameliorated in the knockout mouse with the administration of the antioxidants. Moreover, the impaired vasculogenesis in uterus/placenta was also improved by ascorbic acid supplementation. We thus conclude that ascorbic acid and/or coenzyme Q10 are involved in maintaining ovarian and uterus/placenta homeostasis against insults that are augmented during pregnancy and that their use might have positive effects in terms of improving female fertility.

scholarly journals A hot water extract of turmeric (Curcuma longa) suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production

2017 ◽  
Vol 6 ◽  
Author(s):  
Ryusei Uchio ◽  
Yohei Higashi ◽  
Yusuke Kohama ◽  
Kengo Kawasaki ◽  
Takashi Hirao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Oral Administration ◽  
Alanine Aminotransferase ◽  
Curcuma Longa ◽  
Water Extract ◽  
Hot Water ◽  
Hepatic Tissue ◽  
Hot Water Extract ◽  
Acute Ethanol

AbstractTurmeric (Curcuma longa) is a widely used spice that has various biological effects, and aqueous extracts of turmeric exhibit potent antioxidant activity and anti-inflammatory activity. Bisacurone, a component of turmeric extract, is known to have similar effects. Oxidative stress and inflammatory cytokines play an important role in ethanol-induced liver injury. This study was performed to evaluate the influence of a hot water extract of C. longa (WEC) or bisacurone on acute ethanol-induced liver injury. C57BL/6 mice were orally administered WEC (20 mg/kg body weight; BW) or bisacurone (60 µg/kg BW) at 30 min before a single dose of ethanol was given by oral administration (3·0 g/kg BW). Plasma levels of aspartate aminotransferase and alanine aminotransferase were markedly increased in ethanol-treated mice, while the increase of these enzymes was significantly suppressed by prior administration of WEC. The increase of alanine aminotransferase was also significantly suppressed by pretreatment with bisacurone. Compared with control mice, animals given WEC had higher hepatic tissue levels of superoxide dismutase and glutathione, as well as lower hepatic tissue levels of thiobarbituric acid-reactive substances, TNF-α protein and IL-6 mRNA. These results suggest that oral administration of WEC may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation, at least partly through the effects of bisacurone.

Effects of the Antioxidants Lycium Barbarum and Ascorbic Acid on Reperfusion Liver Injury in Rats

2009 ◽  
Vol 41 (10) ◽  
pp. 4110-4113 ◽  
Author(s):  
N.T. Wang ◽  
H.I. Lin ◽  
D.Y. Yeh ◽  
T.Y. Chou ◽  
C.F. Chen ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Liver Injury ◽  
Lycium Barbarum

Ascorbic acid deficiency affects genes for oxidation–reduction and lipid metabolism in livers from SMP30/GNL knockout mice

2014 ◽  
Vol 1840 (7) ◽  
pp. 2289-2298 ◽  
Author(s):  
Keita Takahashi ◽  
Yuki Kishimoto ◽  
Tomokazu Konishi ◽  
Yasunori Fujita ◽  
Masafumi Ito ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Lipid Metabolism ◽  
Knockout Mice ◽  
Ascorbic Acid Deficiency ◽  
Oxidation Reduction ◽  
Acid Deficiency

Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30/GNL knockout mice

2013 ◽  
Vol 53 (1) ◽  
pp. 177-185 ◽  
Author(s):  
Akiko Amano ◽  
Makoto Tsunoda ◽  
Toshiro Aigaki ◽  
Naoki Maruyama ◽  
Akihito Ishigami
Keyword(s):  
Ascorbic Acid ◽  
Knockout Mice ◽  
Adrenal Glands ◽  
Catecholamine Synthesis ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency

scholarly journals Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: An important role for CXCL1

Hepatology ◽  
2015 ◽  
Vol 62 (4) ◽  
pp. 1070-1085 ◽  
Author(s):  
Binxia Chang ◽  
Ming-Jiang Xu ◽  
Zhou Zhou ◽  
Yan Cai ◽  
Man Li ◽  
...  
Keyword(s):  
Liver Injury ◽  
High Fat Diet ◽  
Acute Liver Injury ◽  
High Fat ◽  
Acute Ethanol

p27Kip1 Inactivation Provides a Proliferative Advantage to Transplanted Hepatocytes in DPPIV/Rag2 Double Knockout Mice after Repeated Host Liver Injury

2003 ◽  
Vol 12 (8) ◽  
pp. 907-919 ◽  
Author(s):  
Ray-Hwang Yuan ◽  
Atsushi Ogawa ◽  
Emi Ogawa ◽  
David Neufeld ◽  
Liang Zhu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Knockout Mice ◽  
Host Liver ◽  
Double Knockout ◽  
Proliferative Advantage

scholarly journals Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice

2012 ◽  
Vol 11 (3) ◽  
pp. 1633-1643 ◽  
Author(s):  
Kristofer S. Fritz ◽  
James J. Galligan ◽  
Matthew D. Hirschey ◽  
Eric Verdin ◽  
Dennis R. Petersen
Keyword(s):  
Liver Injury ◽  
Mouse Model ◽  
Knockout Mice
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