scholarly journals Testing Possible Risk Factors for Idiosyncratic Drug-Induced Liver Injury Using an Amodiaquine Mouse Model and Co-treatment with 1-Methyl-d-Tryptophan or Acetaminophen

ACS Omega ◽  
2021 ◽  
Vol 6 (7) ◽  
pp. 4656-4662
Author(s):  
Tiffany Cho ◽  
Lie Yun Kok ◽  
Jack Uetrecht
Keyword(s):  
Risk Factors ◽  
Liver Injury ◽  
Mouse Model ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Genetic Risk Factors in Drug‐Induced Liver Injury Due to Isoniazid‐Containing Antituberculosis Drug Regimens

2020 ◽  
Author(s):  
Paola Nicoletti ◽  
Harshad Devarbhavi ◽  
Ashish Goel ◽  
Radha Venkatesan ◽  
Chundamannil E. Eapen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Injury ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Antituberculosis Drug ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Drug Regimens

Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate

2013 ◽  
Vol 14 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Cristina Lucía Dávila-Fajardo ◽  
Jesse J Swen ◽  
José Cabeza Barrera ◽  
Henk-Jan Guchelaar
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Liver Injury ◽  
Genetic Risk ◽  
Low Dose ◽  
Genetic Risk Factors ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Dose Methotrexate

scholarly journals Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury

2016 ◽  
Vol 65 (3) ◽  
pp. 532-542 ◽  
Author(s):  
Inmaculada Medina-Caliz ◽  
Mercedes Robles-Diaz ◽  
Beatriz Garcia-Muñoz ◽  
Camilla Stephens ◽  
Aida Ortega-Alonso ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals The Characteristics, Prevalence, and Risk Factors of Drug-Induced Liver Injury Among Brucellosis Inpatients in Xinjiang, China

2021 ◽  
Vol 12 ◽  
Author(s):  
Maermaer Tuohutaerbieke ◽  
Xinjie Li ◽  
Yue Yin ◽  
Wei Chen ◽  
Dongmei Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Injury ◽  
Serum Albumin ◽  
Rating Scale ◽  
Normal Liver ◽  
Hepatocellular Injury ◽  
Drug Induced ◽  
International Consensus ◽  
Drug Induced Liver Injury ◽  
Drug Of Choice

Background: We investigated the prevalence, demographic and clinical features, and risk factors associated with drug-induced liver injury (DILI) during the treatment of brucellosis inpatients in a retrospective study.Methods: We collected the clinical data of 782 brucellosis inpatients admitted at the Shawan County People’s Hospital, Xinjiang, from 2015–2019. All cases were re-evaluated using the international consensus of DILI criteria and RUCAM rating scale. 71 patients were confirmed as DILI cases and compared with 523 other patients with normal liver function.Results: It was indicated that DILI occurred with a prevalence of about 9.08% among brucellosis inpatients receiving drug therapy. Hepatocellular injury was the most common type of DILI (61.97%, 95% confidence interval [CI] 50.34–72.37), followed by mixed (23.94%, 95% CI 15.52–35.04) and cholestatic types (14.08%, 95% CI 7.83–24.02). In addition, 13.64% of the hepatocellular DILI cases fulfilled Hy’s law criteria and only two cases (2.82%) progressed to severe DILI. Most patients adopted the combination of rifampicin, antipyretic analgesics, anti-infective agents, and traditional Chinese medicine for the treatment of brucellosis, with all the 71 patients taking rifampicin as the drug of choice. Multivariable logistic regression analyses indicated that obesity, regular alcohol intake, and decreased serum albumin were the independent risk factors of DILI in patients with brucellosis after adjusting for gender, age, and ethnicity.Conclusion: DILI occurred in a minority of inpatients diagnosed with brucellosis receiving rifampicin-based therapeutic regimen. In addition, obesity, alcohol abuse, and decreased serum albumin were valuable predictors of the risk of DILI in patients with brucellosis.

Sign in / Sign up

Export Citation Format

Share Document