Application of Ultrasound Measurements as PAT Tools for Industrial Crystallization Process Development of Pharmaceutical Compounds

2013 ◽  
Vol 19 (1) ◽  
pp. 110-121 ◽  
Author(s):  
Lydia Helmdach ◽  
Martin P. Feth ◽  
Joachim Ulrich
Keyword(s):  
Crystallization Process ◽  
Process Development ◽  
Pharmaceutical Compounds ◽  
Industrial Crystallization ◽  
Ultrasound Measurements

NMPC of an industrial crystallization process using model-based observers

2010 ◽  
Vol 16 (5) ◽  
pp. 708-716 ◽  
Author(s):  
Cédric Damour ◽  
Michel Benne ◽  
Lionel Boillereaux ◽  
Brigitte Grondin-Perez ◽  
Jean-Pierre Chabriat
Keyword(s):  
Crystallization Process ◽  
Industrial Crystallization ◽  
Model Based

SIMULATION AND NEW SENSOR TECHNOLOGIES FOR INDUSTRIAL CRYSTALLIZATION: A REVIEW

2002 ◽  
Vol 16 (01n02) ◽  
pp. 346-353 ◽  
Author(s):  
RICHARD D. BRAATZ ◽  
MITSUKO FUJIWARA ◽  
DAVID L. MA ◽  
TIMOKLEIA TOGKALIDOU ◽  
DANESH K. TAFTI
Keyword(s):  
High Resolution ◽  
Size Distribution ◽  
Crystal Size ◽  
Crystallization Process ◽  
Significant Proportion ◽  
Nucleation And Growth ◽  
Crystalline Form ◽  
Industrial Crystallization ◽  
Growth From Solution ◽  
Product Effectiveness

A significant proportion of materials are produced in crystalline form. Many of these crystals are produced by nucleation and growth from solution. In these processes, the control of the crystal size distribution can be critically important for efficient downstream operations such as filtration and drying, and product effectiveness (e.g., flowability, bioavailability, tablet stability). Such control has recently become possible due to new sensor technologies that can peer into the crystallization process as it occurs, and high resolution algorithms which can efficiently simulate crystallization processes. This paper provides an overview of recent advances in areas.

Robust Crystallization Process Development for the Metastable δ-form of Pyrazinamide

2015 ◽  
Vol 19 (12) ◽  
pp. 1987-1996 ◽  
Author(s):  
Martin Wijaya Hermanto ◽  
Alvin Yeoh ◽  
Beatrice Soh ◽  
Pui Shan Chow ◽  
Reginald B. H. Tan
Keyword(s):  
Crystallization Process ◽  
Process Development

Crystallization Process Development for the Final Step of the Biocatalytic Synthesis of Islatravir: Comprehensive Crystal Engineering for a Low-Dose Drug

2021 ◽  
Vol 25 (2) ◽  
pp. 308-317
Author(s):  
Eric Sirota ◽  
Thomas Kwok ◽  
Richard J. Varsolona ◽  
Aaron Whittaker ◽  
Teresa Andreani ◽  
...  
Keyword(s):  
Crystal Engineering ◽  
Low Dose ◽  
Crystallization Process ◽  
Process Development
Sign in / Sign up

Export Citation Format

Share Document