Crystallization Process Development of an Active Pharmaceutical Ingredient and Particle Engineering via the Use of Ultrasonics and Temperature Cycling

2003 ◽  
Vol 7 (6) ◽  
pp. 997-1001 ◽  
Author(s):  
Soojin Kim ◽  
Chenkou Wei ◽  
San Kiang
Keyword(s):  
Crystallization Process ◽  
Process Development ◽  
Active Pharmaceutical Ingredient ◽  
Temperature Cycling ◽  
Particle Engineering

Particle Engineering of an Active Pharmaceutical Ingredient for Improved Micromeritic Properties

2017 ◽  
Vol 40 (7) ◽  
pp. 1282-1292 ◽  
Author(s):  
Michał Sowa ◽  
Anneke R. Klapwijk ◽  
Michael Ostendorf ◽  
Wolfgang Beckmann
Keyword(s):  
Active Pharmaceutical Ingredient ◽  
Particle Engineering

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 9. Active Pharmaceutical Ingredient Process Development and Powder Properties

2017 ◽  
Vol 21 (8) ◽  
pp. 1174-1185 ◽  
Author(s):  
Thomas E. La Cruz ◽  
Eric M. Saurer ◽  
Joshua Engstrom ◽  
Michael S. Bultman ◽  
Robert Forest ◽  
...  
Keyword(s):  
Process Development ◽  
Active Pharmaceutical Ingredient ◽  
Powder Properties

Particle engineering by optimization for the unseeded batch cooling crystallization of l-asparagine monohydrate

CrystEngComm ◽  
2017 ◽  
Vol 19 (42) ◽  
pp. 6373-6382 ◽  
Author(s):  
Stutee Bhoi ◽  
Maheswata Lenka ◽  
Debasis Sarkar
Keyword(s):  
Crystallization Process ◽  
Optimization Approach ◽  
Temperature Profiles ◽  
Particle Engineering ◽  
Model Based ◽  
Cooling Crystallization ◽  
Asparagine Monohydrate ◽  
Batch Cooling

A model-based optimization approach is proposed to obtain temperature profiles to achieve the target CSD in a batch cooling crystallization process.

Particle engineering of needle shaped crystals by wet milling and temperature cycling: Optimisation for roller compaction

2018 ◽  
Vol 339 ◽  
pp. 641-650 ◽  
Author(s):  
David Wilson ◽  
Matthew Bunker ◽  
David Milne ◽  
Anna Jawor-Baczynska ◽  
Andre Powell ◽  
...  
Keyword(s):  
Temperature Cycling ◽  
Roller Compaction ◽  
Particle Engineering ◽  
Wet Milling
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