On the Fischer Indole Synthesis of 7-Ethyltryptophol—Mechanistic and Process Intensification Studies under Continuous Flow Conditions

2013 ◽  
Vol 17 (2) ◽  
pp. 294-302 ◽  
Author(s):  
Bernhard Gutmann ◽  
Michael Gottsponer ◽  
Petteri Elsner ◽  
David Cantillo ◽  
Dominique M. Roberge ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Process Intensification ◽  
Flow Conditions ◽  
Fischer Indole Synthesis ◽  
Indole Synthesis

A continuous flow microwave-assisted fischer indole synthesis of 7-Ethyltryptophol

2017 ◽  
Vol 121 ◽  
pp. 144-148 ◽  
Author(s):  
Jianguo Xu ◽  
Jiangang Yu ◽  
Yi Jin ◽  
Jie Li ◽  
Zhiqun Yu ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Microwave Assisted ◽  
Fischer Indole Synthesis ◽  
Indole Synthesis

Development of a highly efficient single-mode microwave applicator with a resonant cavity and its application to continuous flow syntheses

RSC Advances ◽  
2015 ◽  
Vol 5 (14) ◽  
pp. 10204-10210 ◽  
Author(s):  
Saori Yokozawa ◽  
Noriyuki Ohneda ◽  
Ken Muramatsu ◽  
Tadashi Okamoto ◽  
Hiromichi Odajima ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Resonant Cavity ◽  
Single Mode ◽  
Alder Reaction ◽  
Diels Alder ◽  
Reaction Products ◽  
Fischer Indole Synthesis ◽  
Diels Alder Reaction ◽  
Microwave Applicator ◽  
Indole Synthesis

A new microwave applicator specifically designed for continuous flow synthesis has been developed and tested in the Fischer indole synthesis and in the Diels–Alder reaction to afford the reaction products at a scale of 100 g h−1.

Process Intensification for Obtaining a Cannabidiol Intermediate by Photo-oxygenation of Limonene under Continuous-Flow Conditions

2020 ◽  
Vol 24 (10) ◽  
pp. 2017-2024
Author(s):  
Anderson R. Aguillón ◽  
Raquel A. C. Leão ◽  
Kleber Thiago de Oliveira ◽  
Timothy John Brocksom ◽  
Leandro S. M. Miranda ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Process Intensification ◽  
Flow Conditions

A continuous-flow fischer indole synthesis of 3-methylindole in an ionic liquid

2017 ◽  
Vol 7 (2) ◽  
pp. 33-36 ◽  
Author(s):  
Jiangang Yu ◽  
Jianguo Xu ◽  
Zhiqun Yu ◽  
Yi Jin ◽  
Jie Li ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Continuous Flow ◽  
Fischer Indole Synthesis ◽  
Indole Synthesis

Metal–organic frameworks for the removal of the emerging contaminant atenolol under real conditions

2021 ◽  
Vol 50 (7) ◽  
pp. 2493-2500
Author(s):  
Sara Rojas ◽  
Jorge A. R. Navarro ◽  
Patricia Horcajada
Keyword(s):  
Continuous Flow ◽  
Metal Organic Frameworks ◽  
Fixed Bed ◽  
Emerging Contaminant ◽  
Flow Conditions ◽  
Metal Organic ◽  
Fixed Bed System

A defective Metal-Organic Frameworks as an improved material for the construction of a fixed-bed system working under continuous flow conditions for the removal of the emerging contaminant atenolol.

Modular Counter-Fischer–Indole Synthesis through Radical-Enolate Coupling

2021 ◽  
Vol 23 (3) ◽  
pp. 1096-1102
Author(s):  
Hyunho Chung ◽  
Jeongyun Kim ◽  
Gisela A. González-Montiel ◽  
Paul Ha-Yeon Cheong ◽  
Hong Geun Lee
Keyword(s):  
Fischer Indole Synthesis ◽  
Indole Synthesis

scholarly journals Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions

Tetrahedron ◽  
2021 ◽  
pp. 132305
Author(s):  
Harry R. Smallman ◽  
Jamie A. Leitch ◽  
Tom McBride ◽  
Steven V. Ley ◽  
Duncan L. Browne
Keyword(s):  
Continuous Flow ◽  
Flow Conditions

scholarly journals Achieving selectivity in porphyrin bromination through a DoE-driven optimization under continuous flow conditions

2020 ◽  
Author(s):  
Paolo Zardi ◽  
Michele Maggini ◽  
Tommaso Carofiglio
Keyword(s):  
Reaction Time ◽  
Design Of Experiment ◽  
Continuous Flow ◽  
Optimization Process ◽  
Porphyrin Ring ◽  
Flow Conditions ◽  
Reaction Parameters ◽  
Synthetic Procedure ◽  
Relevant Factors ◽  
Post Functionalization

AbstractThe post-functionalization of porphyrins through the bromination in β position of the pyrrolic rings is a relevant transformation because the resulting bromoderivatives are useful synthons to covalently link a variety of chemical architectures to a porphyrin ring. However, single bromination of porphyrins is a challenging reaction for the abundancy of reactive β-pyrrolic positions in the aromatic macrocycle. We herein report a synthetic procedure for the efficient preparation of 2-bromo-5,10,15,20-tetraphenylporphyrin (1) under continuous flow conditions. The use of flow technology allows to reach an accurate control over critical reaction parameters such as temperature and reaction time. Furthermore, by performing the optimization process through a statistical DoE (Design of Experiment) approach, these parameters could be properly adjusted with a limited number of experiments. This process led us to a better understanding of the relevant factors that govern porphyrins monobromination and to obtain compound 1 with an unprecedent 80% yield.

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