Process Intensification for Obtaining a Cannabidiol Intermediate by Photo-oxygenation of Limonene under Continuous-Flow Conditions

2020 ◽  
Vol 24 (10) ◽  
pp. 2017-2024
Author(s):  
Anderson R. Aguillón ◽  
Raquel A. C. Leão ◽  
Kleber Thiago de Oliveira ◽  
Timothy John Brocksom ◽  
Leandro S. M. Miranda ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Process Intensification ◽  
Flow Conditions

On the Fischer Indole Synthesis of 7-Ethyltryptophol—Mechanistic and Process Intensification Studies under Continuous Flow Conditions

2013 ◽  
Vol 17 (2) ◽  
pp. 294-302 ◽  
Author(s):  
Bernhard Gutmann ◽  
Michael Gottsponer ◽  
Petteri Elsner ◽  
David Cantillo ◽  
Dominique M. Roberge ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Process Intensification ◽  
Flow Conditions ◽  
Fischer Indole Synthesis ◽  
Indole Synthesis

Metal–organic frameworks for the removal of the emerging contaminant atenolol under real conditions

2021 ◽  
Vol 50 (7) ◽  
pp. 2493-2500
Author(s):  
Sara Rojas ◽  
Jorge A. R. Navarro ◽  
Patricia Horcajada
Keyword(s):  
Continuous Flow ◽  
Metal Organic Frameworks ◽  
Fixed Bed ◽  
Emerging Contaminant ◽  
Flow Conditions ◽  
Metal Organic ◽  
Fixed Bed System

A defective Metal-Organic Frameworks as an improved material for the construction of a fixed-bed system working under continuous flow conditions for the removal of the emerging contaminant atenolol.

scholarly journals Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions

Tetrahedron ◽  
2021 ◽  
pp. 132305
Author(s):  
Harry R. Smallman ◽  
Jamie A. Leitch ◽  
Tom McBride ◽  
Steven V. Ley ◽  
Duncan L. Browne
Keyword(s):  
Continuous Flow ◽  
Flow Conditions

scholarly journals Achieving selectivity in porphyrin bromination through a DoE-driven optimization under continuous flow conditions

2020 ◽  
Author(s):  
Paolo Zardi ◽  
Michele Maggini ◽  
Tommaso Carofiglio
Keyword(s):  
Reaction Time ◽  
Design Of Experiment ◽  
Continuous Flow ◽  
Optimization Process ◽  
Porphyrin Ring ◽  
Flow Conditions ◽  
Reaction Parameters ◽  
Synthetic Procedure ◽  
Relevant Factors ◽  
Post Functionalization

AbstractThe post-functionalization of porphyrins through the bromination in β position of the pyrrolic rings is a relevant transformation because the resulting bromoderivatives are useful synthons to covalently link a variety of chemical architectures to a porphyrin ring. However, single bromination of porphyrins is a challenging reaction for the abundancy of reactive β-pyrrolic positions in the aromatic macrocycle. We herein report a synthetic procedure for the efficient preparation of 2-bromo-5,10,15,20-tetraphenylporphyrin (1) under continuous flow conditions. The use of flow technology allows to reach an accurate control over critical reaction parameters such as temperature and reaction time. Furthermore, by performing the optimization process through a statistical DoE (Design of Experiment) approach, these parameters could be properly adjusted with a limited number of experiments. This process led us to a better understanding of the relevant factors that govern porphyrins monobromination and to obtain compound 1 with an unprecedent 80% yield.

Ammonium formate as a green hydrogen source for clean semi-continuous enzymatic dynamic kinetic resolution of (+/−)-α-methylbenzylamine

RSC Advances ◽  
2014 ◽  
Vol 4 (26) ◽  
pp. 13620-13625 ◽  
Author(s):  
Amanda S. de Miranda ◽  
Rodrigo O. M. A. de Souza ◽  
Leandro S. M. Miranda
Keyword(s):  
Continuous Flow ◽  
Kinetic Resolution ◽  
Ammonium Formate ◽  
Flow Conditions ◽  
Dynamic Kinetic Resolution

The chemoenzymatic dynamic kinetic resolution of (+/−)-α-methylbenzylamine under continuous flow conditions in the presence of Pd/BaSO4as racemization catalyst and ammonium formate as reductant is described.

scholarly journals Size Selective Synthesis of Superparamagnetic Nanoparticles in Thin Fluids under Continuous Flow Conditions

2008 ◽  
Vol 18 (6) ◽  
pp. 922-927 ◽  
Author(s):  
Suk Fun Chin ◽  
K. Swaminathan Iyer ◽  
Colin L. Raston ◽  
Martin Saunders
Keyword(s):  
Continuous Flow ◽  
Superparamagnetic Nanoparticles ◽  
Selective Synthesis ◽  
Flow Conditions
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