A Commercial Continuous Flow Microwave Reactor Evaluated for Scale-Up

2010 ◽  
Vol 14 (4) ◽  
pp. 926-930 ◽  
Author(s):  
Fabio Bergamelli ◽  
Mauro Iannelli ◽  
Jameel A. Marafie ◽  
Jonathan D. Moseley
Keyword(s):  
Continuous Flow ◽  
Scale Up ◽  
Microwave Reactor

Flow Microwave Technology and Microreactors in Synthesis

2013 ◽  
Vol 66 (2) ◽  
pp. 131 ◽  
Author(s):  
Ian R. Baxendale ◽  
Christian Hornung ◽  
Steven V. Ley ◽  
Juan de Mata Muñoz Molina ◽  
Anders Wikström
Keyword(s):  
Microwave Heating ◽  
Continuous Flow ◽  
Scale Up ◽  
Chemical Processes ◽  
Organic Chemical ◽  
Chemical Transformations ◽  
Microwave Technology ◽  
Carbon Doped ◽  
Microwave Reactor ◽  
Reaction Media

A bespoke microwave reactor with a glass containment cell has been developed for performing continuous flow reactions under microwave heating. The prototype unit has been evaluated using a series of standard organic chemical transformations enabling scale-up of these chemical processes. As part of the development, a carbon-doped PTFE reactor insert was utilized to allow the heating of poorly absorbing reaction media, increasing the range of solvents and scope of reactions that can be performed in the device.

Design of a continuous flow immobilized-cell reactor for biosynthetical production of L-aspartic acid

1985 ◽  
Vol 50 (10) ◽  
pp. 2122-2133 ◽  
Author(s):  
Jindřich Zahradník ◽  
Marie Fialová ◽  
Jan Škoda ◽  
Helena Škodová
Keyword(s):  
Aspartic Acid ◽  
Continuous Flow ◽  
Immobilized Cells ◽  
Scale Up ◽  
Fixed Bed ◽  
Packed Bed ◽  
Fixed Bed Reactor ◽  
Experimental Program ◽  
Design Parameters ◽  
Immobilized Cell

An experimental study was carried out aimed at establishing a data base for an optimum design of a continuous flow fixed-bed reactor for biotransformation of ammonium fumarate to L-aspartic acid catalyzed by immobilized cells of the strain Escherichia alcalescens dispar group. The experimental program included studies of the effect of reactor geometry, catalytic particle size, and packed bed arrangement on reactor hydrodynamics and on the rate of substrate conversion. An expression for the effective reaction rate was derived including the effect of mass transfer and conditions of the safe conversion-data scale-up were defined. Suggestions for the design of a pilot plant reactor (100 t/year) were formulated and decisive design parameters of such reactor were estimated for several variants of problem formulation.

A Simple Continuous Flow Microwave Reactor

2005 ◽  
Vol 70 (17) ◽  
pp. 7003-7006 ◽  
Author(s):  
Mark C. Bagley ◽  
Robert L. Jenkins ◽  
M. Caterina Lubinu ◽  
Christopher Mason ◽  
Robin Wood
Keyword(s):  
Continuous Flow ◽  
Microwave Reactor

scholarly journals Diels–Alder reactions of myrcene using intensified continuous-flow reactors

2017 ◽  
Vol 13 ◽  
pp. 120-126 ◽  
Author(s):  
Christian H Hornung ◽  
Miguel Á Álvarez-Diéguez ◽  
Thomas M Kohl ◽  
John Tsanaktsidis
Keyword(s):  
Continuous Flow ◽  
Flow Reactor ◽  
Scale Up ◽  
Reaction Times ◽  
Alder Reaction ◽  
Diels Alder ◽  
Flow Reactors ◽  
Diels Alder Reaction ◽  
Naturally Occurring ◽  
Continuous Flow Reactors

This work describes the Diels–Alder reaction of the naturally occurring substituted butadiene, myrcene, with a range of different naturally occurring and synthetic dienophiles. The synthesis of the Diels–Alder adduct from myrcene and acrylic acid, containing surfactant properties, was scaled-up in a plate-type continuous-flow reactor with a volume of 105 mL to a throughput of 2.79 kg of the final product per day. This continuous-flow approach provides a facile alternative scale-up route to conventional batch processing, and it helps to intensify the synthesis protocol by applying higher reaction temperatures and shorter reaction times.

ChemInform Abstract: Petasis Olefination in a Continuous-Flow Microwave Reactor: exo-Glycals from Sugar Lactones.

ChemInform ◽  
2011 ◽  
Vol 43 (2) ◽  
pp. no-no
Author(s):  
Stefan Koch ◽  
Holger Loewe ◽  
Horst Kunz
Keyword(s):  
Continuous Flow ◽  
Microwave Reactor

scholarly journals Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib

2020 ◽  
Vol 24 (10) ◽  
pp. 2217-2227
Author(s):  
Manuel Köckinger ◽  
Benjamin Wyler ◽  
Christof Aellig ◽  
Dominique M. Roberge ◽  
Christopher A. Hone ◽  
...  
Keyword(s):  
Building Block ◽  
Continuous Flow ◽  
Scale Up

Direct amide formation in a continuous-flow system mediated by carbon disulfide

2020 ◽  
Vol 10 (23) ◽  
pp. 7814-7818
Author(s):  
György Orsy ◽  
Ferenc Fülöp ◽  
István M. Mándity
Keyword(s):  
Carbon Disulfide ◽  
Continuous Flow ◽  
Flow System ◽  
Scale Up ◽  
Direct Flow ◽  
Continuous Flow System ◽  
Amide Formation

We report a direct flow-based synthesis of amides. The developed approach is prominently simple and various aliphatic and aromatic amides were synthetized with excellent yields. The technology is considerably robust and easy scale-up was carried out.

scholarly journals N-Acetylation of Amines in Continuous-Flow with Acetonitrile—No Need for Hazardous and Toxic Carboxylic Acid Derivatives

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1985 ◽  
Author(s):  
György Orsy ◽  
Ferenc Fülöp ◽  
István M. Mándity
Keyword(s):  
Carboxylic Acid ◽  
Continuous Flow ◽  
Scale Up ◽  
Drug Substance ◽  
Aliphatic Amines ◽  
Aromatic And Aliphatic Amines

A continuous-flow acetylation reaction was developed, applying cheap and safe reagent, acetonitrile as acetylation agent and alumina as catalyst. The method developed utilizes milder reagent than those used conventionally. The reaction was tested on various aromatic and aliphatic amines with good conversion. The catalyst showed excellent reusability and a scale-up was also carried out. Furthermore, a drug substance (paracetamol) was also synthesized with good conversion and yield.

scholarly journals Sonochemical preparation of alumina-spheres loaded with Pd nanoparticles for 2-butyne-1,4-diol semi-hydrogenation in a continuous flow microwave reactor

RSC Advances ◽  
2018 ◽  
Vol 8 (13) ◽  
pp. 7029-7039 ◽  
Author(s):  
Emanuela Calcio Gaudino ◽  
Maela Manzoli ◽  
Diego Carnaroglio ◽  
Zhilin Wu ◽  
Giorgio Grillo ◽  
...  
Keyword(s):  
Heterogeneous Catalysis ◽  
Continuous Flow ◽  
Flow Reactor ◽  
Pd Nanoparticles ◽  
Microwave Assisted ◽  
Continuous Flow Reactor ◽  
Microwave Reactor

A novel protocol for microwave-assisted alkyne semi-hydrogenation under heterogeneous catalysis in a continuous flow reactor is reported herein.

Scale-up and Optimization of a Continuous Flow Synthesis of an α-Thio-β-chloroacrylamide

2020 ◽  
Vol 24 (10) ◽  
pp. 1978-1987
Author(s):  
Olga C. Dennehy ◽  
Denis Lynch ◽  
Stuart G. Collins ◽  
Anita R. Maguire ◽  
Humphrey A. Moynihan
Keyword(s):  
Continuous Flow ◽  
Scale Up ◽  
Flow Synthesis
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