Preparation of the HIV Attachment Inhibitor BMS-663068. Part 9. Active Pharmaceutical Ingredient Process Development and Powder Properties

2017 ◽  
Vol 21 (8) ◽  
pp. 1174-1185 ◽  
Author(s):  
Thomas E. La Cruz ◽  
Eric M. Saurer ◽  
Joshua Engstrom ◽  
Michael S. Bultman ◽  
Robert Forest ◽  
...  
Keyword(s):  
Process Development ◽  
Active Pharmaceutical Ingredient ◽  
Powder Properties

Impact of agitated drying on the powder properties of an active pharmaceutical ingredient

2011 ◽  
Vol 210 (3) ◽  
pp. 308-314 ◽  
Author(s):  
E. Kougoulos ◽  
C.E. Chadwick ◽  
M.D. Ticehurst
Keyword(s):  
Active Pharmaceutical Ingredient ◽  
Powder Properties

scholarly journals Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design

2016 ◽  
Vol 66 (2) ◽  
pp. 191-206 ◽  
Author(s):  
Zoltán-István Szabó ◽  
Blanka Székely-Szentmiklósi ◽  
Boglárka Deák ◽  
István Székely-Szentmiklósi ◽  
Béla Kovács ◽  
...  
Keyword(s):  
Experimental Design ◽  
Cost Effective ◽  
Active Pharmaceutical Ingredient ◽  
Experimental Designs ◽  
Angle Of Repose ◽  
Time Saving ◽  
Enalapril Maleate ◽  
Tablet Properties ◽  
Powder Properties ◽  
Active Substances

Abstract To evaluate the influence of different variables on tablet formulations containing enalapril maleate and indapamide as active substances, two separate experimental designs were employed: one for evaluating powder properties and the other for tablet characteristics. Because of the low active pharmaceutical ingredient content, it was hypothesized that both powder and tablet properties could be determined only by the characteristics of excipients. In order to test this assumption, both experimental designs were done with placebo mixtures. The optimized formulation was then evaluated both with and without APIs. Results indicated that filler and lubricant percentage, along with compression force, were the most important variables during the formulation study. The optimized formulation showed similar characteristics in both cases for all responses, except for angle of repose and friability where only minor differences were observed. The combination of the applied approaches (using placebo composition and fractional experimental design) proved to be efficient, cost effective and time saving.

Example of Finishing Technologies as Key Elements for Successful Active Pharmaceutical Ingredient Process Development

2004 ◽  
Vol 8 (3) ◽  
pp. 376-380 ◽  
Author(s):  
Martin Müller ◽  
Ricardo Schneeberger ◽  
Dierk Wieckhusen ◽  
Martyn Cooper
Keyword(s):  
Process Development ◽  
Active Pharmaceutical Ingredient

Scale-up of agitated drying: Effect of shear stress and hydrostatic pressure on active pharmaceutical ingredient powder properties

AIChE Journal ◽  
2014 ◽  
Vol 61 (2) ◽  
pp. 407-418 ◽  
Author(s):  
Brenda Remy ◽  
Weston Kightlinger ◽  
Eric M. Saurer ◽  
Nathan Domagalski ◽  
Benjamin J. Glasser
Keyword(s):  
Shear Stress ◽  
Hydrostatic Pressure ◽  
Scale Up ◽  
Active Pharmaceutical Ingredient ◽  
Powder Properties

Advanced TEM sample preparation techniques for submicron Si devices

1995 ◽  
Vol 53 ◽  
pp. 516-517 ◽  
Author(s):  
P. B. Basham ◽  
H. L. Tsai
Keyword(s):  
Sample Preparation ◽  
Process Development ◽  
Light Transmission ◽  
Specific Area ◽  
Turnaround Time ◽  
Small Hole ◽  
Area Of Interest ◽  
Transmission Electron ◽  
Polished Side ◽  
Preparation Techniques

The use of transmission electron microscopy (TEM) to support process development of advanced microelectronic devices is often challenged by a large amount of samples submitted from wafer fabrication areas and specific-spot analysis. Improving the TEM sample preparation techniques for a fast turnaround time is critical in order to provide a timely support for customers and improve the utilization of TEM. For the specific-area sample preparation, a technique which can be easily prepared with the least amount of effort is preferred. For these reasons, we have developed several techniques which have greatly facilitated the TEM sample preparation.For specific-area analysis, the use of a copper grid with a small hole is found to be very useful. With this small-hole grid technique, TEM sample preparation can be proceeded by well-established conventional methods. The sample is first polished to the area of interest, which is then carefully positioned inside the hole. This polished side is placed against the grid by epoxy Fig. 1 is an optical image of a TEM cross-section after dimpling to light transmission.

The Structure and Properties of MoSi2 Thin Film in Mos Process

1980 ◽  
Vol 38 ◽  
pp. 326-327
Author(s):  
C.K. Wu ◽  
P. Chang ◽  
N. Godinho
Keyword(s):  
Thin Film ◽  
Integrated Circuits ◽  
High Performance ◽  
Large Scale ◽  
Process Development ◽  
Structure And Properties ◽  
Metal Silicides ◽  
High Oxidation ◽  
Important Approach ◽  
High Oxidation Resistance

Recently, the use of refractory metal silicides as low resistivity, high temperature and high oxidation resistance gate materials in large scale integrated circuits (LSI) has become an important approach in advanced MOS process development (1). This research is a systematic study on the structure and properties of molybdenum silicide thin film and its applicability to high performance LSI fabrication.

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