The Development of a Manufacturing Route for the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 1:  Synthesis of the Key Intermediate 2,3,4,5-Tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic Acid Methyl Ester, SB-235349

2003 ◽  
Vol 7 (5) ◽  
pp. 655-662 ◽  
Author(s):  
Ian P. Andrews ◽  
Richard J. Atkins ◽  
Gary F. Breen ◽  
John S. Carey ◽  
Michael A. Forth ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Methyl Ester ◽  
Receptor Antagonist ◽  
Acid Methyl Ester ◽  
Acid Methyl

Synthesen von Heterocyclen, CCIV1 Reaktionen mit cyclischen Oxalylverbindungen, XIX2 Eine einfache Synthese von 5-Benzoyl-6-phenyl-1.3-dioxin-4-onen / Syntheses of Heterocycles, CCIV1 Reactions of Cyclic Oxalyl Compounds, XIX 2 A Simple Synthesis of 5 Benzoyl-6-phenyl-1,3-dioxin-4-ones

1977 ◽  
Vol 32 (6) ◽  
pp. 701-704 ◽  
Author(s):  
Gert Kollenz ◽  
Erich Ziegler ◽  
Walter Ott ◽  
Gert Kriwetz
Keyword(s):  
Acetic Acid ◽  
Methyl Ester ◽  
Acrylic Acid ◽  
Acid Methyl Ester ◽  
The Other ◽  
Simple Synthesis ◽  
Acid Methyl ◽  
Other Hand

4-Benzoyl-5-phenyl-2,3-dihydrofuran-2,3-dione (1) reacts with aldehydes or ketones via the acylketene-intermediate (2) yielding the 1,3-dioxin-4-ones (3). The aldehyde derivatives (3 a-e) can be converted into the anilino-chalcone (5) or the anilino acrylic acid (6) by treating with aniline at 20 °C. 6 and diazomethane combine to the acrylic acid methyl ester (7), which by heating (200 °C) is cyclisized to the quinolin-4-ole (8). On the other hand, the keto derivatives 3f-h and aniline give the dibenzoyl acetic acid anilide (9).

scholarly journals Synthesis, characterization and properties of a copper complex with dicyano acetic acid methyl ester ligand derived from tetracyanoethylene

Polyhedron ◽  
2017 ◽  
Vol 121 ◽  
pp. 13-18 ◽  
Author(s):  
Chen-Neng Lin ◽  
Ling-Zhi Tang ◽  
Shi-Tao Ren ◽  
Li-Ping Ye ◽  
Cai-Hong Chen ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Methyl Ester ◽  
Copper Complex ◽  
Acid Methyl Ester ◽  
Acid Methyl

scholarly journals {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3

2015 ◽  
Vol 2015 ◽  
pp. 1-10
Author(s):  
Ye Li ◽  
Wenjing Wang ◽  
Xiaoxue Xu ◽  
Shiyue Sun ◽  
Xiaoyu Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Acetic Acid ◽  
Methyl Ester ◽  
Acid Methyl Ester ◽  
High Sensitivity ◽  
Inhibitory Effect ◽  
Methyl Ethyl ◽  
Nadph Oxidase 4 ◽  
Acid Methyl ◽  
Cellular Reactive Oxygen Species

{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) is a novel indole compound, which possessed high efficacy against many cancers xenografted in mice without obvious toxicity. In this study, we aimed to investigate the effects of MIAM on human hepatocellular carcinoma (HCC) Bel-7402 cells and its resistant variants Bel-7402/5FU. MIAM inhibited the growth of HCC more potent in Bel-7402/5FU cells than its parent cells. MIAM increased cellular reactive oxygen species (ROS) levels, induced cell apoptosis, and arrested cell cycle in G0/G1phase. MIAM might exert its action on Bel-7402/5FU cells through activation of NADPH oxidase 4 (NOX4)/p22, Sirtuin3 (SIRT3)/SOD2, and SIRT3/p53/p21pathways. MIAM might inhibit HCC growth through the modulation of SIRT3. When SIRT3 was silenced, the inhibitory effect of MIAM on Bel-7402/5FU was lowered, showing the characteristic of resistance against MIAM, whereas Bel-7402/5FU cells with high expression of SIRT3 by SIRT3 adenovirus infection demonstrated the high sensitivity to MIAM. These results suggested that MIAM might exert its action against Bel-7402/5FU growth through upregulation of SIRT3. We suggested that MIAM might be a promising candidate compound which could develop as a potent anticancer agent targeting NOX4 and SIRT3 activation.

scholarly journals Profil GCMS Senyawa Kimia Ekstrak Metanol Isolat Cendawan Entomopatogen Beauveria Bassiana Dan Akar Cabai Sebagai Pemacu Pertumbuhan Cabai

2020 ◽  
Vol 4 (2) ◽  
pp. 106-118
Author(s):  
Magdalena Saragih ◽  
Trizelia Trizelia ◽  
Nurbailis Nurbailis ◽  
Yusniwati Yusniwati
Keyword(s):  
Acetic Acid ◽  
Methyl Ester ◽  
Palmitic Acid ◽  
Chemical Compound ◽  
Entomopathogenic Fungus ◽  
Acid Methyl Ester ◽  
Chemical Compounds ◽  
Hexadecanoic Acid ◽  
Ethanoic Acid ◽  
Acid Methyl

The aim of this study was to identify the chemical compound methanol extract of entomopathogenic fungus Beauveria bassiana from insect walang sangit and the chemical compound roots of red chili plants that were able to stimulate the growth of chilli plants after being applied with entomopathogenic fungus   B. bassiana through seed immersion inoculation using GCMS method. The chemical compound identified as a growth booster in   B. bassiana fungus isolates from the insect walang sangit is an Acetic acid Ethanoic acid Ethylic acid Glacial acetic acid CH3COOH, Hexadecanoic acid, methyl ester (CAS) Methylpalmitate Uniphat A60, n-Hexadecanoic acid Hexadecanoic acid n-Hexadecoic acid Palmitic acid, Dianhydromannitol and Ergosta-5,7,22-trien-3-ol, (3.beta., 22E) - (CAS) Ergosterol (CAS), while the chili root contains Acetic acid Ethanoic acid Ethylic acid Glacials acetic acid CH3COOH, Hexadecanoic acid, methyl ester (CAS) Methyl palmitate Uniphat A60, n -Hexadecanoic acid Hexadecanoic acid Palmitic acid, 8, 11- octadecadienoic acid, methyl ester (CAS) METHYL 8, 11-OCTADECADIENOATE, (23S)-ethylcholest-5-en-3.beta.-ol.s It can be concluded that some of the chemical compounds in methanol extracts identified in chili roots have similarities with chemical compounds that exist in   B. bassiana entomopathogenic fungus which are potential as stimulers of chili plant growth

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