Asymmetric Construction of Quaternary Carbon Centers by Sequential Conjugate Addition of Lithium Amide and in Situ Alkylation: Utility in the Synthesis of (−)-Aspidospermidine

2009 ◽  
Vol 11 (3) ◽  
pp. 653-655 ◽  
Author(s):  
Mayuko Suzuki ◽  
Yoshito Kawamoto ◽  
Takeo Sakai ◽  
Yasutomo Yamamoto ◽  
Kiyoshi Tomioka
Keyword(s):  
Conjugate Addition ◽  
Quaternary Carbon ◽  
Lithium Amide ◽  
Carbon Centers

Stereoselective formation of tertiary and quaternary carbon centers via inverse conjugate addition of carbonucleophiles to allenic esters

Tetrahedron ◽  
2010 ◽  
Vol 66 (39) ◽  
pp. 7720-7725 ◽  
Author(s):  
Ana Lúcia Cardoso ◽  
Ana Matos Beja ◽  
Manuela Ramos Silva ◽  
Jesús M. de los Santos ◽  
Francisco Palacios ◽  
...  
Keyword(s):  
Conjugate Addition ◽  
Quaternary Carbon ◽  
Carbon Centers ◽  
Allenic Esters

Enantioselective Copper-Catalyzed Conjugate Addition to 2- or 3-Substituted Cyclopent-2-en-1-ones: Construction of Stereogenic Quaternary Carbon Centers

Synlett ◽  
2007 ◽  
Vol 2007 (13) ◽  
pp. 2057-2060 ◽  
Author(s):  
Alexandre Alexakis ◽  
Magali Vuagnoux-d’Augustin ◽  
Stefan Kehrli
Keyword(s):  
Conjugate Addition ◽  
Quaternary Carbon ◽  
Carbon Centers

The Catalytic Asymmetric Dearomatization of Tryptamine for Accessing meso-Contiguous Quaternary Carbon Centers of Oligomeric Cyclotryptamine Alkaloids: a Formal Synthesis of Hodgkinsine B

2021 ◽  
Author(s):  
Hongbo Wei ◽  
Guzhou Chen ◽  
Huanhuan Zou ◽  
Zhiqiang Zhou ◽  
Pan Lei ◽  
...  
Keyword(s):  
Quaternary Carbon ◽  
Formal Synthesis ◽  
Carbon Centers ◽  
Catalytic Asymmetric

Herein, we disclosed a catalytic asymmetric dearomatization (CADA) of tryptamine via tandem [4+2] cycloaddition/cyclization with o-azaxylylene in situ generated from functionalized 3-bromooxinidole promoted by chiral N,N’-dioxide/Ni(BF4)2. A variety of dimeric...

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