Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines

2014 ◽  
Vol 16 (17) ◽  
pp. 4566-4569 ◽  
Author(s):  
Mei-Xin Zhao ◽  
Hong-Lei Bi ◽  
Rong-Hui Jiang ◽  
Xu-Wei Xu ◽  
Min Shi
Keyword(s):  
Cascade Reaction ◽  
Cinchona Alkaloid ◽  
Mannich Cyclization

Diastereo- and enantioselective Mannich/cyclization cascade reaction of isocyanoacetates with cyclic sulfamide ketimines by cinchona alkaloid squaramide/AgOAc cooperative catalysis

2018 ◽  
Vol 16 (25) ◽  
pp. 4641-4649 ◽  
Author(s):  
Mei-Xin Zhao ◽  
Zhi-Wen Dong ◽  
Guang-Yu Zhu ◽  
Xiao-Li Zhao ◽  
Min Shi
Keyword(s):  
Cascade Reaction ◽  
Optically Active ◽  
Cinchona Alkaloid ◽  
Cooperative Catalysis ◽  
Mannich Cyclization

This reaction provides facile access to a variety of optically active imidazoline-fused sulfahydantoin derivatives in excellent yields and good to excellent stereoselectivities.

Organocatalyzed enantioselective Michael addition/cyclization cascade reaction of 3-isothiocyanato oxindoles with arylidene malonates

2016 ◽  
Vol 14 (47) ◽  
pp. 11250-11260 ◽  
Author(s):  
Raghunath Chowdhury ◽  
Mukesh Kumar ◽  
Sunil K. Ghosh
Keyword(s):  
Michael Addition ◽  
Cascade Reaction ◽  
Cinchona Alkaloid ◽  
Bifunctional Catalysts

Both enantiomers of functionalized 3,2′-pyrrolidinyl spirooxindoles were obtainedviaa Michael-cyclization cascade reaction using pseudoenantiomeric cinchona alkaloid derived thiourea based bifunctional catalysts.

Squaramide−catalysed asymmetric Michael addition/cyclization cascade reactions of 4-arylidene-2,3-dioxopyrrolidines with 2-isothiocyanato-1-indanones

2021 ◽  
Author(s):  
Xiqiang Hou ◽  
Jiang-Bo Wen ◽  
Li Yan ◽  
Da-Ming Du
Keyword(s):  
Michael Addition ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Cinchona Alkaloid ◽  
Highly Efficient ◽  
Asymmetric Michael Addition

A highly efficient cinchona alkaloid‐derived squaramide catalysed asymmetric Michael/cyclization cascade reaction of 4‐ arylmethylidene‐2,3‐dioxopyrrolidines with 2‐isothiocyanato‐1‐indanones was successfully developed. This protocol provides an efficient and mild access to obtain indanone‐derived...

A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters

2015 ◽  
Vol 13 (22) ◽  
pp. 6371-6379 ◽  
Author(s):  
Yong-Yuan Gui ◽  
Jian Yang ◽  
Liang-Wen Qi ◽  
Xiao Wang ◽  
Fang Tian ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Cascade Reaction ◽  
Cinchona Alkaloid

Enantioselective sulfa-Michael/aldol reaction of isoindigos has been successfully developed to afford bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters.

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