Diastereo‐ and Enantioselective Mannich/Cyclization Cascade Reaction Access to Chiral Benzothiazolopyrimidine Derivatives

2021 ◽  
Author(s):  
Yan Zhang ◽  
Jia‐Hui Yang ◽  
Ying‐Qi Xia ◽  
Lin Dong ◽  
Fen‐Er Chen
Keyword(s):  
Cascade Reaction ◽  
Mannich Cyclization

scholarly journals Facile Synthesis of 2H-Benzo[h]Chromenes via an Arylamine-Catalyzed Mannich Cyclization Cascade Reaction

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3617
Author(s):  
Yueteng Zhang ◽  
Peng Ji ◽  
Xiang Meng ◽  
Feng Gao ◽  
Fanxun Zeng ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
High Efficiency ◽  
Cascade Reaction ◽  
Facile Synthesis ◽  
Quinone Methides ◽  
Reaction Conditions ◽  
Notable Feature ◽  
Efficient Generation ◽  
Mannich Cyclization

A simple arylamine-catalyzed Mannich-cyclization cascade reaction was developed for facile synthesis of substituted 2H-benzo[h]chromenes. The notable feature of the process included the efficient generation of ortho-quinone methides (o-QMs) catalyzed by a simple aniline. The mild reaction conditions allowed for a broad spectrum of 1- and 2-naphthols and trans-cinnamaldehydes to engage in the cascade sequence with high efficiency.

Diastereo- and enantioselective Mannich/cyclization cascade reaction of isocyanoacetates with cyclic sulfamide ketimines by cinchona alkaloid squaramide/AgOAc cooperative catalysis

2018 ◽  
Vol 16 (25) ◽  
pp. 4641-4649 ◽  
Author(s):  
Mei-Xin Zhao ◽  
Zhi-Wen Dong ◽  
Guang-Yu Zhu ◽  
Xiao-Li Zhao ◽  
Min Shi
Keyword(s):  
Cascade Reaction ◽  
Optically Active ◽  
Cinchona Alkaloid ◽  
Cooperative Catalysis ◽  
Mannich Cyclization

This reaction provides facile access to a variety of optically active imidazoline-fused sulfahydantoin derivatives in excellent yields and good to excellent stereoselectivities.

Cu-Catalyzed Cascade Reaction of Isoxazoles with Diaryliodonium Salts for the Synthesis of Acridines

2020 ◽  
Vol 17 (12) ◽  
pp. 944-950
Author(s):  
Shangrong Zhu ◽  
Xuechen Lu ◽  
Qiuneng Xu ◽  
Jian Li ◽  
Shenghu Yan
Keyword(s):  
Cascade Reaction ◽  
Efficient Synthesis ◽  
Acridine Derivatives ◽  
Diaryliodonium Salts

A straightforward and efficient synthesis of acridine derivatives via a copper-catalyzed cascade reaction among isoxazoles and diaryliodonium salts is achieved. Various mono-, multi-substituted and 9-substituted acridine derivatives could be obtained in moderate to good yields. The process has gone through tandem double arylation and Friedel-Crafts reactions.

Synthesis of 1,2,3-Triazole-Fused Indole Derivatives via Copper-Catalyzed Cascade Reaction

Synthesis ◽  
2021 ◽  
Author(s):  
Fengtao Zhou ◽  
Qiuyu Zhang ◽  
Kashif Majeed ◽  
Bangjie Liu
Keyword(s):  
Quantum Efficiency ◽  
Photophysical Properties ◽  
Cascade Reaction ◽  
Tandem Reaction ◽  
Indole Derivatives ◽  
Wide Range

AbstractA copper-catalyzed tandem reaction has been developed for the synthesis of 1,2,3-triazole-fused indole derivatives. This protocol allowed us to access a wide range of 1,2,3-triazole-fused indole derivatives in moderate to excellent yields. The 1,2,3-triazole-fused indole derivatives emit blue and greenish light when excited at 365 nm. The products were further explored for their quantum efficiency and photophysical properties.

scholarly journals Synthesis of Carbazoles by a Diverted Bischler–Napieralski Cascade Reaction

2021 ◽  
Author(s):  
Matteo Faltracco ◽  
Said Ortega-Rosales ◽  
Elwin Janssen ◽  
Răzvan C. Cioc ◽  
Christophe M. L. Vande Velde ◽  
...  
Keyword(s):  
Cascade Reaction
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