A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters

2015 ◽  
Vol 13 (22) ◽  
pp. 6371-6379 ◽  
Author(s):  
Yong-Yuan Gui ◽  
Jian Yang ◽  
Liang-Wen Qi ◽  
Xiao Wang ◽  
Fang Tian ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Cascade Reaction ◽  
Cinchona Alkaloid

Enantioselective sulfa-Michael/aldol reaction of isoindigos has been successfully developed to afford bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters.

ChemInform Abstract: Simple and Practical Direct Asymmetric Aldol Reaction of Hydroxyacetone Catalyzed by 9-Amino Cinchona Alkaloid Tartrates.

ChemInform ◽  
2011 ◽  
Vol 42 (37) ◽  
pp. no-no
Author(s):  
Pawel Czarnecki ◽  
Agnieszka Plutecka ◽  
Jacek Gawronski ◽  
Karol Kacprzak
Keyword(s):  
Aldol Reaction ◽  
Cinchona Alkaloid ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction

Simple and practical direct asymmetric aldol reaction of hydroxyacetone catalyzed by 9-amino Cinchona alkaloid tartrates

2011 ◽  
Vol 13 (5) ◽  
pp. 1280 ◽  
Author(s):  
Paweł Czarnecki ◽  
Agnieszka Plutecka ◽  
Jacek Gawroński ◽  
Karol Kacprzak
Keyword(s):  
Aldol Reaction ◽  
Cinchona Alkaloid ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction

Organocatalyzed enantioselective Michael addition/cyclization cascade reaction of 3-isothiocyanato oxindoles with arylidene malonates

2016 ◽  
Vol 14 (47) ◽  
pp. 11250-11260 ◽  
Author(s):  
Raghunath Chowdhury ◽  
Mukesh Kumar ◽  
Sunil K. Ghosh
Keyword(s):  
Michael Addition ◽  
Cascade Reaction ◽  
Cinchona Alkaloid ◽  
Bifunctional Catalysts

Both enantiomers of functionalized 3,2′-pyrrolidinyl spirooxindoles were obtainedviaa Michael-cyclization cascade reaction using pseudoenantiomeric cinchona alkaloid derived thiourea based bifunctional catalysts.

Squaramide−catalysed asymmetric Michael addition/cyclization cascade reactions of 4-arylidene-2,3-dioxopyrrolidines with 2-isothiocyanato-1-indanones

2021 ◽  
Author(s):  
Xiqiang Hou ◽  
Jiang-Bo Wen ◽  
Li Yan ◽  
Da-Ming Du
Keyword(s):  
Michael Addition ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Cinchona Alkaloid ◽  
Highly Efficient ◽  
Asymmetric Michael Addition

A highly efficient cinchona alkaloid‐derived squaramide catalysed asymmetric Michael/cyclization cascade reaction of 4‐ arylmethylidene‐2,3‐dioxopyrrolidines with 2‐isothiocyanato‐1‐indanones was successfully developed. This protocol provides an efficient and mild access to obtain indanone‐derived...

Enantioselective synthesis of trifluoromethyl substituted cyclohexanones via an organocatalytic cascade Michael/aldol reaction

2020 ◽  
Vol 18 (8) ◽  
pp. 1607-1611 ◽  
Author(s):  
Hongzhou Yang ◽  
Qingqing Wang ◽  
Yuan Luo ◽  
Ling Ye ◽  
Xinying Li ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Enantioselective Synthesis ◽  
Ring Closure ◽  
Cinchona Alkaloid ◽  
Primary Amines

An enantioselective Michael-initiated ring-closure process was established to construct β-CF3-cyclohexanones or β-CF3-cyclohexenones with cinchona alkaloid-based primary amines.

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