Free-Radical Cascade Alkylarylation of Alkenes with Simple Alkanes: Highly Efficient Access to Oxindoles via Selective (sp3)C–H and (sp2)C–H Bond Functionalization

2013 ◽  
Vol 16 (2) ◽  
pp. 382-385 ◽  
Author(s):  
Zejiang Li ◽  
Ye Zhang ◽  
Lizhi Zhang ◽  
Zhong-Quan Liu
Keyword(s):  
Free Radical ◽  
Bond Functionalization ◽  
Highly Efficient ◽  
Efficient Access ◽  
Radical Cascade

Copper-catalyzed radical cascade oxyalkylation of olefinic amides with simple alkanes: highly efficient access to benzoxazines

2017 ◽  
Vol 53 (56) ◽  
pp. 7961-7964 ◽  
Author(s):  
Jie Wang ◽  
Ruoyu Sang ◽  
Xiaolong Chong ◽  
Yinuo Zhao ◽  
Wenjie Fan ◽  
...  
Keyword(s):  
Bond Functionalization ◽  
Highly Efficient ◽  
Efficient Access ◽  
Radical Cascade

A copper-catalyzed C(sp3)–H bond functionalization of simple alkanes with olefinic amides was developed for the synthesis of benzoxazine derivatives.

Metal-free radical cascade dichloromethylation of activated alkenes using CH2Cl2: highly selective activation of the C–H bond

RSC Advances ◽  
2014 ◽  
Vol 4 (110) ◽  
pp. 64855-64859 ◽  
Author(s):  
Yunfei Tian ◽  
Zhong-Quan Liu
Keyword(s):  
Free Radical ◽  
Dicumyl Peroxide ◽  
Cascade Process ◽  
Selective Activation ◽  
Metal Free ◽  
Efficient Access ◽  
Radical Cascade

A dicumyl peroxide-initiated highly selective activation of the (sp3)C–H bond in dichloromethane (DCM, CH2Cl2) has been achieved, which allows efficient access to dichloronated oxindoles via a free-radical cascade process.

A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

2021 ◽  
Author(s):  
Tao Fan ◽  
Yan Liu ◽  
Caina Jiang ◽  
Yanli Xu ◽  
Yan-Yan Chen
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Mild Conditions ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

Metal-Free Cascade Methylation/Cyclization of N-Alkyl-N-methacryloylbenzamides with Dicumyl Peroxide

Synlett ◽  
2017 ◽  
Vol 29 (05) ◽  
pp. 617-620 ◽  
Author(s):  
Yan-Ning Niu ◽  
Xiao-Feng Xia ◽  
Yuan Yuan
Keyword(s):  
Free Radical ◽  
Dicumyl Peroxide ◽  
Metal Free ◽  
Wide Range ◽  
Radical Cascade ◽  
Convenient Access

A metal-free radical cascade methylation/cyclization of a wide range of N-alkyl-N-methacryloylbenzamides by using dicumyl peroxide as the methylating reagent provides a convenient access to a series of methylated isoquinoline-1,3-diones in moderate yields.

Enantioselective synthesis of tetrahydroisoquinolines via catalytic intramolecular asymmetric reductive amination

2021 ◽  
Author(s):  
Ruixia Liu ◽  
Jingkuo Han ◽  
Bin Li ◽  
Xian Liu ◽  
Zhao Wei ◽  
...  
Keyword(s):  
Reductive Amination ◽  
Enantioselective Synthesis ◽  
Iridium Complex ◽  
Highly Efficient ◽  
Efficient Access

A highly efficient intramolecular asymmetric reductive amination transformation catalyzed by an iridium complex of tBu-ax-Josiphos has been realized, providing an efficient access to various THIQ alkaloids.

Decoding the Complex Free Radical Cascade by Using a DNA Framework‐Based Artificial DNA Encoder

2021 ◽  
Author(s):  
Lili Zhang ◽  
Linlin Wang ◽  
Xi Yuan ◽  
Minjuan Zhong ◽  
Hong Chen ◽  
...  
Keyword(s):  
Free Radical ◽  
Artificial Dna ◽  
Radical Cascade

A free radical assisted strategy for preparing functionalized carbon nanotubes as a highly efficient nucleating agent for poly(l-lactide)

RSC Advances ◽  
2015 ◽  
Vol 5 (21) ◽  
pp. 16604-16610 ◽  
Author(s):  
Zi-Jing Zhang ◽  
Wei Cui ◽  
Huan Xu ◽  
Lan Xie ◽  
Huan Liu ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Free Radical ◽  
Radical Polymerization ◽  
Free Radical Polymerization ◽  
Nucleating Agent ◽  
Functionalized Carbon Nanotubes ◽  
Highly Efficient

Schematic illumination of the fabrication of the CNT-OEG via free radical polymerization.

A Green and Highly Efficient Naphthalimide Visible Photoinitiator with an Ability Initiating Free Radical Polymerization under Air

2018 ◽  
Vol 219 (24) ◽  
pp. 1800256 ◽  
Author(s):  
Jianjing Yang ◽  
Can Xu ◽  
Ying Xiong ◽  
Xiaoling Wang ◽  
Yujun Xie ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Polymerization ◽  
Free Radical Polymerization ◽  
Highly Efficient

scholarly journals Recent Developments in Polyene Cyclizations and Their Applications in Natural Product Synthesis

Synthesis ◽  
2018 ◽  
Vol 51 (01) ◽  
pp. 67-82 ◽  
Author(s):  
Anthony Barrett ◽  
Tsz-Kan Ma ◽  
Thomas Mies
Keyword(s):  
Transition Metal ◽  
Natural Product ◽  
Lewis Acid ◽  
Multiple Bond ◽  
Natural Product Synthesis ◽  
Cyclization Reactions ◽  
Cascade Cyclizations ◽  
Highly Efficient ◽  
Recent Developments ◽  
Radical Cascade

Cascade polyene cyclization reactions are highly efficient and elegant bioinspired transformations that involve simultaneous multiple bond constructions to rapidly generate complex polycyclic molecules. This review summarizes the most prominent work on a variety of cationic and radical cascade cyclizations and their applications in natural product synthesis published between 2014 and 2018.1 Introduction2 Cationic Polyene Cyclizations2.1 Lewis Acid Mediated Polyene Cyclizations2.2 Brønsted Acid Mediated Polyene Cyclizations2.3 Halogen Electrophile Initiated Polyene Cyclizations2.4 Sulfur Electrophile Initiated Polyene Cyclizations2.5 Transition-Metal-Mediated Cationic Polyene Cyclizations3 Radical Polyene Cyclizations3.1 Transition-Metal-Mediated Radical Polyene Cyclizations3.2 Photocatalyst-Mediated Polyene Cyclizations4 Origin of Stereocontrol in Polyene Cyclizations5 Conclusion

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